Development of High‐Pressure Mass Spectrometry for Handheld and Benchtop Analyzers

Blakeman, Kenion H.; Miller, Scott E.

doi:10.1002/9781119636489.ch16

Cited by 5 publications

(4 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prepared compounds' mass spectra revealed that the charge ratio m/z+ was compatible with their molar masses [28][29][30]. The cobalt complex's mass spectra revealed the charge m/z+ -to-mass (M.wt=596) ratio, which is related to the complex's molecular weight.…”

Section: Mass Spectrum Measurementsmentioning

confidence: 87%

Preparation and Characterization of Fluorone Ligand Complexes for Co+2, Mn+2, and Fe+2 Metallic Ions

Salem,

Ali,

Al-Obaidi

2023

JUAPS

View full text Add to dashboard Cite

In this study, new complexes are produced by bonding of transition metal dinuclear chlorides (CoCl 2 .6H 2 O, MnCl 2 .4H 2 O, and FeCl 2 .6H 2 O) with a polychelated ligand called 9-Phenyl-2,3,7-trihydroxy-6-fluorone, represented by (L), in a 1:2 (metal: ligand) ratio. Applying the appropriate chemical and physical methods, such as melting points, molar electrical conductivity, magnetic sensitivity, FT-IR, UV-Visible, and mass spectrometric studies, the produced complexes were characterized. All complexes are non-electrolytic, according to analyzes of molar electrical conductivity. All complexes have an octahedral structure, according to studies of magnetic sensitivity and Uv-Visible spectra. The mass spectrometry measurements showed the presence of the molar mass bands of the complex and the appearance of other bands resulting from the fragmentation of the complexes. For the metallic complexes spectra, FT-IR revealed a shift in the shape and intensity of the complexes bands at lower frequencies. The bonding of the metal to the oxygen atom can be observed by this shift in the bond stretch of the ligands. The size of the coordination between the ligand and the ions of the metallic elements is the cause. The measurement of the complexes' melting point is high, which suggests that the resultant complexes are quite stable. .

show abstract

Section: Mass Spectrum Measurementsmentioning

confidence: 87%

Preparation and Characterization of Fluorone Ligand Complexes for Co+2, Mn+2, and Fe+2 Metallic Ions

Salem,

Ali,

Al-Obaidi

2023

JUAPS

View full text Add to dashboard Cite

show abstract

“…6 Mass spectrometry (MS) often delivers larger dynamic ranges, enhancements to selectivity and sensitivity, and complex mixture analysis capabilities beyond alternative techniques such as spectroscopy or ion mobility spectrometry. 7 However, instrumental specifics will ultimately determine the mass resolution and compound differentiation (e.g., time-of-flight [TOF] 8 vs highpressure ion trap mass analyzers 9 ) or capabilities to inform on compound structure by tandem mass spectrometry (e.g., ion trap or triple quadrupole vs TOF mass analyzers). Recent years have seen an expansion in fieldable MS solutions for forensic and security sectors, 10 enabled both by advancements in miniaturization and the progression of ambient ionization.…”

Section: Introductionmentioning

confidence: 99%

In-line Thermal Desorption and Dielectric Barrier Discharge Ionization for Rapid Mass Spectrometry Detection of Explosives

Forbes,

Robinson,

Sisco

et al. 2024

Preprint

View full text Add to dashboard Cite

Thermal desorption (TD) of wipe-based samples was coupled with an in-line dielectric barrier discharge ionization (DBDI) source and rugged compact time-of-flight mass spectrometer (MS) for the detection of explosives, propellants, and post-blast debris. The chromatography-free TD-DBDI-MS platform enabled rapid and sensitive detection of organic nitramine, nitrate ester, and nitroaromatic explosives, as well as black powder and black powder substitute propellants. Parametric investigations characterized the response to TD temperature, and optimized DBDI voltage, aerodynamically assisted entrainment, and fragmentation through in-source collision induced dissociation (isCID). Excess nitrate generated by the DBDI source yielded predominantly nitrate-adduct formation. Sub-nanogram sensitivities were demonstrated for all explosives investigated, except for nitroglycerin, specifically due to its volatility. Further, most analytes/explosives exhibited tens of picogram sensitivities. The platform also demonstrated the detection of propellant and military explosives from post-blast debris. The TD-DBDI-MS system performed well without the need for aerodynamically assisted entrainment (and the associated rough pump), which along with requiring no additional gasses (i.e., N2 ¬or He) or solvents, aid in potential field deployment. The ease of TD-DBDI attachment and removal added trace solid or liquid residue detection to the rugged mass spectrometer, designed primarily for analysis of volatile organic and inorganic compounds.

show abstract

“…6 Mass spectrometry (MS) often delivers larger dynamic ranges, enhancements to selectivity and sensitivity, and complex mixture analysis capabilities beyond alternative techniques such as spectroscopy or ion mobility spectrometry. 7 However, instrumental specifics will ultimately determine the mass resolution and compound differentiation (e.g., time-offlight [TOF] 8 vs high-pressure ion trap mass analyzers 9 ) or capabilities to inform on compound structure by tandem mass spectrometry (e.g., ion trap or triple quadrupole vs TOF mass analyzers). Recent years have seen an expansion in fieldable MS solutions for forensic and security sectors, 10 enabled both by advancements in miniaturization and the progression of ambient ionization.…”

Section: ■ Introductionmentioning

confidence: 99%

In-Line Thermal Desorption and Dielectric Barrier Discharge Ionization for Rapid Mass Spectrometry Detection of Explosives

Forbes,

Robinson,

Sisco

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

Thermal desorption (TD) of wipe-based samples was coupled with an in-line dielectric barrier discharge ionization (DBDI) source and rugged compact timeof-flight mass spectrometer (MS) for the detection of explosives, propellants, and postblast debris. The chromatography-free TD-DBDI-MS platform enabled rapid and sensitive detection of organic nitramine, nitrate ester, and nitroaromatic explosives as well as black powder and black powder substitute propellants. Parametric investigations characterized the response to TD temperature and optimized DBDI voltage, aerodynamically assisted entrainment, and fragmentation through in-source collision induced dissociation (isCID). Excess nitrate generated by the DBDI source yielded predominantly nitrate-adduct formation. Subnanogram sensitivities were demonstrated for all explosives investigated, except for nitroglycerin, specifically due to its volatility. Further, most analytes/explosives exhibited tens of picograms sensitivities. The platform also demonstrated the detection of propellant and military explosives from postblast debris. The TD-DBDI-MS system performed well without the need for aerodynamically assisted entrainment (and the associated rough pump), which along with requiring no additional gases (i.e., N 2 or He) or solvents, aid in potential field deployment. The ease of TD-DBDI attachment and removal added trace solid or liquid residue detection to the rugged mass spectrometer, designed primarily for the analysis of volatile organic and inorganic compounds.

show abstract

Development of High‐Pressure Mass Spectrometry for Handheld and Benchtop Analyzers

Cited by 5 publications

References 125 publications

Preparation and Characterization of Fluorone Ligand Complexes for Co+2, Mn+2, and Fe+2 Metallic Ions

Preparation and Characterization of Fluorone Ligand Complexes for Co+2, Mn+2, and Fe+2 Metallic Ions

In-line Thermal Desorption and Dielectric Barrier Discharge Ionization for Rapid Mass Spectrometry Detection of Explosives

In-Line Thermal Desorption and Dielectric Barrier Discharge Ionization for Rapid Mass Spectrometry Detection of Explosives

Contact Info

Product

Resources

About