Development of highly stable colloidal dispersions of gelled-oil nanoparticles loaded with cuminaldehyde

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D3: Preparation, Characterization, and Physicochemical Stability

“…The high efficiency of the lipid gelled structure to encapsulate the bioactive component was also reported previously in colloidal dispersion. 26 Compared to the previous report on vitamin D 3 encapsulation in liposomes using a thin-film hydration–sonication method at the same concentrations of PC and CHO, which reported an EE around 57%, 33 the obtained EE in the present work for the novel structure of liposomes stabilized with the organogel network was 1.25-fold greater. Although Mohammadi et al.…”

“…In brief, TEM results confirmed the results of particle size measurements conducted by DLS. However, there were some differences in the liposome size determined by TEM and DLS, which can be attributed to the differences in the sample preparation methods (e.g., staining and drying), as well as to different physical principles of the two techniques, 26,61 but the overall trends were similar.…”

“…Moreover, the possible presence of FFAs in the organogelator and soybean oil might contribute to the observed more negative charge in nanoliposomes stabilized by the organogel network within the lipid bilayer shell. 26 These high negative surface charges were indicative of high strong stability of freshly prepared liposomes. As clearly seen from Figure 5 , the electronegative zeta potential values remained relatively constant for the control sample up to 60 days.…”

“…Viscosity and dynamic rheological measurements were also performed using an MCR 302 controlled stress/strain rheometer (Anton Paar, Graz, Austria) equipped with a parallel plate geometry. 26 The strain sweep test from 0.002 to 1% at a constant frequency of 1 Hz was performed to determine the linear viscoelastic region (LVR) of the organogel. Then, the frequency sweep (0.01–10 Hz) and the temperature ramp from 5 to 80 °C at the rate of 2 °C/min and 1 Hz frequency were carried out inside the LVR region.…”

“… 22 Although there are several works on the potential of organogels for delivery applications in pharmaceutical and cosmetic applications, 23 , 24 there are only a few examples of organogel applications in bulk or emulsified forms to increase the bioaccessibility of poorly water-soluble bioactive components in food systems. 25 , 26 Vitamin D is a fat-soluble vitamin that can be produced in the skin by sunlight exposure. Vitamin D 3 (cholecalciferol) , as an active form of vitamin D, is essential to control calcium and phosphorus absorption in the human body.…”