Development of HPLC Optical Purity Testing Method of Denomapine and Application to Its Photostability
Kohei KAWABATA,
Mai SANDANBATA,
Hiroyuki NISHI
Abstract:Direct enantiomer separation of denopamine (DP, active form: R (-)-form), which is an optically active and an orally administrable cardiotonic agent, was investigated by HPLC with β-cyclodextrin (β-CD) immobilized chiral stationary phases (CSPs). Successful enantiomer separation under the reversed-phase mode was achieved by a β-CD having a phenyl moiety immobilized CSP with large resolution within 10 min. Optical purity testing and assay of tablets by the HPLC method developed were validated for specificity, l… Show more
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