Development of human amniotic epithelial cell-derived extracellular vesicles as cell-free therapy for dry eye disease

Yi, Soojin; Kim, Jeongho; Kim, Mi Ju; Yae, Che Gyem; Kim, Ki Hean; Kim, Hong Kyun

doi:10.1016/j.jtos.2024.09.006

The Ocular Surface

2024

DOI: 10.1016/j.jtos.2024.09.006

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Development of human amniotic epithelial cell-derived extracellular vesicles as cell-free therapy for dry eye disease

Soojin Yi,

Jeongho Kim,

Mi Ju Kim

et al.

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2024

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Cited by 1 publication

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Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

Al Monla,

Daien,

Michon

2024

Front. Bioeng. Biotechnol.

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The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts—sometimes supplemented with keratoprostheses—these options are not suitable for all corneal defects. Consequently, the development of bioartificial corneal tissue has emerged as a critical research area, aiming to address the global shortage of human cornea donors. Bioengineered corneas hold considerable promise as substitutes, with the potential to replace either specific layers or the entire thickness of damaged corneas. This review first delves into the structural anatomy of the human cornea, identifying key attributes necessary for successful corneal tissue bioengineering. It then examines various corneal pathologies, current treatments, and their limitations. Finally, the review outlines the primary approaches in corneal tissue engineering, exploring cell-free, cell-based, and scaffold-based options as three emerging strategies to address corneal failure.

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Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

Al Monla,

Daien,

Michon

2024

Front. Bioeng. Biotechnol.

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Development of human amniotic epithelial cell-derived extracellular vesicles as cell-free therapy for dry eye disease

Cited by 1 publication

References 94 publications

Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

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