Development of hybrid 3D-printed structure with aligned drug-loaded fibres using in-situ custom designed templates

Muldoon, Kirsty; Feng, Yu; Dooher, Thomas; O'Connor, Caolan; Wang, Baolin; David Wang, Hui-Min; Ahmad, Zeeshan; McLaughlin, James; Chang, Ming-Wei

doi:10.1016/j.jddst.2023.104921

Cited by 2 publications

(2 citation statements)

References 50 publications

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“…The focus of nanomedicine should be on exploring the new properties of medical materials that emerge when structures are manipulated at the molecular level ( Muldoon et al, 2023 ). The future of nanomedicines increasingly relies on the development of novel structures and the associated fabrication techniques for potential clinical applications and commercial products.…”

Section: Resultsmentioning

confidence: 99%

“…The terminology derives from the material conversion mechanism, in which electrostatic energy (electro) is utilized to process working liquid (hydro) through a powerful interactive process (dynamic). During this process, the atomization of the liquids transfers the fluid into solid products (Bai et al, 2022;Cao et al, 2022;He et al, 2022;Song et al, 2022;Wang H. et al, 2023;Du et al, 2023;Ji et al, 2023;Xu et al, 2023;Yang et al, 2023;Yao et al, 2023;Yu and Xu, 2023). For electrospinning and electrospraying, nanofibers and microparticles are the main products, respectively (Zhou et al, 2023c;.…”

Section: Introductionmentioning

confidence: 99%

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A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Sun,

Zhou,

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe a variety of dosage forms with different administration methods, which fail to provide an efficient and convenient mode of drug delivery. The aim of this work was to develop a new type of hybrid material incorporating both electrosprayed core-shell microparticles and electrospun nanofibers. A traditional Chinese medicine (Ningmitai, NMT) and a Western medicine (ciprofloxacin, CIP) were co-encapsulated within this material and were designed to be released in a separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as a hydrophilic filament-forming polymer and pH-sensitive Eudragit® S100 (ES100) as the particulate polymeric matrix, a combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying and blending electrospinning, was used to create the hybrids in a single-step and straightforward manner. A series of characterization methods were conducted to analyze both the working process and its final products. Scanning electron microscopy and transmission electron microscopy revealed that the EHDA hybrids comprised of both CIP-PVP nanofibers and NMT-ES100 core-shell microparticles. Multiple methods confirmed the rapid release of CIP and the sustained release of NMT. The antibacterial experiments indicated that the hybrids exhibited a more potent antibacterial effect against Escherichia coli dh5α and Bacillus subtilis Wb800 than either the separate nanofibers or microparticles. The amalgamation of fibrous nanomedicine and particulate micromedicine can expand the horizon of new types of medicines. The integration of electrospinning and coaxial electrospraying provides a straightforward approach to fabrication. By combining hydrophilic soluble polymers and pH-sensitive polymers in the hybrids, we can ensure the separate sequential controlled release of CIP and NMT for a potential synergistic and convenient therapy for bacterial prostatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Sun,

Zhou,

Chen

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Chen,

Zhou,

Fang

et al. 2023

Macro Materials & Eng

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In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution of a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by a novel spinneret, is homemade for conducting the three processes. The three types of products are electrospun nanofibers E1, electrosprayed microparticles E2, and core‐shell nanofibers E3. SEM and TEM results indicate that they have the anticipated morphologies and inner structures. X‐ray diffraction and Fourier Transform Infrared results verify that KET is mainly amorphous in all the composites due to its fine compatibility with HPMC. In vitro dissolution tests demonstrate that the drug rapid release performances has an order of E3>E1>E2≫KET powders. The fast dissolution mechanisms are suggested and the advantages of the three products are compared. The super performance of E3 in furnishing the rapid release is attributed to a synergistic action of small size (of the shell thickness), high porosity, amorphous state of drug, and the solubility of HPMC. EHDA nanostructures can support the development of nano drug delivery systems (DDSs) through tailoring the spatial distribution of drug molecules within the nano products.

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Development of hybrid 3D-printed structure with aligned drug-loaded fibres using in-situ custom designed templates

Cited by 2 publications

References 50 publications

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

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