Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation

Schiraldi, Chiara; D’Agostino, Antonella; Oliva, Adriana; Flamma, Floriana; Rosa, Alfredo De; Apicella, Antonio; Aversa, Raffaella; Rosa, Mario De

doi:10.1016/j.biomaterials.2003.10.059

Cited by 91 publications

(117 citation statements)

References 17 publications

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“…This path is a combination of several combined research, industrial and theoretical activities (Fig. 2) such as biomimetic new hybrid ceramopolymeric material development (Schiraldi et al, 2004;Aversa et al, 2016a;2016b;2016c;Gramanzini et al, 2016) (Fig. 3), maximum exploitation of potentialities of the additive manufacturing in new production (Aversa et al, 2016a) (Fig.…”

Section: An Evolutionary Design Biomedical Case Study: Biomechanics Amentioning

confidence: 99%

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Aversa¹,

Petrescu²,

Petrescu³

et al. 2016

American Journal of Engineering and Applied Sciences

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An innovative, design-driven, sustainable approach in conceiving, developing, producing, using new materials can be effective in strengthening the competiveness and success of creative industries linked to manufacturing (e.g., biomedical, architecture, automotive, art, crafts, supports for cultural items, decoration, fashion, furniture, lighting, interior design materials and products, jewels, luxury, media supports, publishing, sport and toys), adding value to products and processes also by 'immaterial' factors (e.g., trend translation, enhanced sensations, values). The vision that the research and the advancement of scientific and technological knowledge can be driven by the needs of sustainable development of products and goods has been revived as a strategy for sustainable development. In the evolutionary Design process, creativity determines the mutation of an object shape (material or structure morphology) and this triggers an evolutionary design that repeatedly involves technological development of material, shape and structure. A Biomedical product evolutionary design case study based on these principles has been specifically addressed to the dissemination and spreading of innovative material and technology greener solutions. The use of the evolutionary design in the creative medical industry sectors, while adopting sustainable and socially responsible approach to reduce energy consumption and environmental impact conveys a holistic view of the industrial design process in the field of biomedical application.

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Section: An Evolutionary Design Biomedical Case Study: Biomechanics Amentioning

confidence: 99%

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Aversa¹,

Petrescu²,

Petrescu³

et al. 2016

American Journal of Engineering and Applied Sciences

Self Cite

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“…Nevertheless, they should be able at the same time to readily biodegrade after the formation of the new tissue in order to fully integrate with it (Kabra et al, 1991;Montheard et al, 1992;Peluso et al, 1997;Schiraldi et al, 2004;Buzea et al, 2015;Aversa et al, 2016a;2016c;2016f;2016g;2016h;2016i;2016j;2016k;2016l;2016m;2016n;2016o).…”

Section: Introductionmentioning

confidence: 99%

Nano-Diamond Hybrid Materials for Structural Biomedical Application

Aversa¹,

Petrescu

Apicella³

et al. 2017

American Journal of Biochemistry and Biotechnology

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The development of new diamond based bio-mechanically active hybrid nano-structured scaffolds for cartilage cells tissue engineering are proposed in this study. Innovative tissue engineering biomimetic materials based on hydrogel have shown attractive physical, biological and mechanical properties in several biomedical applications. A highly biocompatible novel hybrid material based on nanodiamonds and hydrophilic poly-(hydroxyl-ethyl-methacrylate) (pHEMA) is proposed. The aim of this paper is to describe the chemical and analytical procedures for the preparation of nanofilled hybrid composites possessing biomimetic, osteoconductive and osteoinductivity properties that can be useful in the design of bio-mechanically active innovative bone scaffolding systems for stem cell differentiation and growth. A more rigid and rubber transparent hybrid nano-composites are predicted to posses improved mechanical strength overwhelming one of the major weaknesses of hydrogels, which is due their poor mechanical characteristics, for applications in biomedical structural application.

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“…Creating ideal scaffolds for bones is a growing argument for research. Such an ideal framework should provide a rigid and elastic mesh to temporarily replace damaged bone function while creating a bioactive substrate for bone regeneration, integrating it fully (Montheard et al, 1992;Kabra et al, 1991;Schiraldi et al, 2004;Aversa et al, 2017a;2017b).…”

Section: Introductionmentioning

confidence: 99%

Hybrid Ceramo-Polymeric Nano-Diamond Composites

Apicella¹,

Aversa²,

Petrescu³

2018

American Journal of Engineering and Applied Sciences

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This paper discusses a new class of bio-mechanical scaffolds active for tissue engineering based on a nano-diamond-filled hydrophilic polymer matrix. The new biomaterials used have special mechanical and biological properties for which they should be extensively studied for their use for various advanced biomedical applications. The new hybrid material has been prepared using 2 and 5% by volume of detonating nanodiamonds and poly (hydroxy-ethyl-methacrylate) hydrophilic. Both the mechanical and biological properties specific to the nanocomposite are hybrids in nature. The paper presents the analytical procedures of the hybrid material and the preliminary mechanical characterization. This class of hybrid materials has a high potential for biomimetic, osteoconductive and osteoinductive applications as active bio-mechanical bones for increasing osteoblasts and differentiating stem cells. At the same time, these hybrid nano-composites possess a much improved mechanical strength that exceeds the mechanical deficiencies of the hydrogels traditionally used for bone regeneration and can be applied as an osteoinductive coating for metal trabecular scaffolds. Micro-trabecular metal structures coated with active and osteoinductive biomechanical ceramic-polymeric biomechanical scaffolds are proposed to recreate macro and micro-distribution of bone stresses and deformations.

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Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation

Cited by 91 publications

References 17 publications

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Nano-Diamond Hybrid Materials for Structural Biomedical Application

Hybrid Ceramo-Polymeric Nano-Diamond Composites

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