Development of immediate release (IR) 3D-printed oral dosage forms with focus on industrial relevance

Fanous, Marina; Gold, Sarah; Hirsch, Stefan; Ogorka, Joerg; Imanidis, Georgios

doi:10.1016/j.ejps.2020.105558

Cited by 41 publications

(10 citation statements)

References 27 publications

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“…SEM has been used to evaluate the surface morphology [ 9 , 161 ], cross-sectional morphology [ 145 ] and also to observe the integrity of structures present in the formulation [ 150 ] in both filaments and 3D printed products. µCT is a non-destructive image technique that has been used to observe the inner structure of the formulations [ 134 ], making it possible to calculate the surface area, solid volume and open/close pores volume of formulations [ 171 ]. Confocal Raman microscopy is an innovative and highly sensitive technique that allows the identification of information about the components in the structure, using in tin samples [ 172 ].…”

Section: Quality Assessment Of Dosage Forms Produced By Hme and 3d Printingmentioning

confidence: 99%

“…Confocal Raman microscopy is an innovative and highly sensitive technique that allows the identification of information about the components in the structure, using in tin samples [ 172 ]. In dosage forms produced by HME and 3D printing, confocal Raman has also been used to identify the crystallinity state of molecules [ 54 , 171 ] and to evaluate the spatial distribution of the components in the formulation [ 150 ].…”

Section: Quality Assessment Of Dosage Forms Produced By Hme and 3d Printingmentioning

confidence: 99%

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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: Quality Assessment Of Dosage Forms Produced By Hme and 3d Printingmentioning

confidence: 99%

Section: Quality Assessment Of Dosage Forms Produced By Hme and 3d Printingmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…4 Graphic illustration of slicing aspect ratio (AR s ) refinement to achieve optimum part filling, and surface finish; If AR s is too low droplets will be deposited too close together resulting in an overfilled part and if AR s is too high droplets will be too spaced out resulting in an underfilled part of APF printed tablets printed (n = 6) with eight different infill densities, all individual tablets were within 93-105% of the average mass at each infill density. FDM printed tablet weight variabilities are commonly much larger due to the diameter of the feeding filaments which is difficult to control [41].…”

Section: Apf Printed Porous Tablets Characterisationmentioning

confidence: 99%

Direct Granule Feeding of Thermal Droplet Deposition 3D Printing of Porous Pharmaceutical Solid Dosage Forms Free of Plasticisers

McDonagh

Belton

2022

Pharm Res

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Purpose To develop a new direct granule fed 3D printing method for manufacturing pharmaceutical solid dosage forms with porous structures using a thermal droplet deposition technology. Methods Eudragit® E PO was used as the model polymer, which is well-known to be not FDM printable without additives. Wet granulation was used to produce drug loaded granules as the feedstock. The flow and feedability of the granules were evaluated. The physicochemical properties and in vitro drug release performance of the granules and the printed tablets were fully characterised. Results Using the method developed by this study, Eudragit E PO was printed with a model drug into tablets with infills ranging from 30–100%, without additives. The drug was confirmed to be molecularly dispersed in the printed tablets. The printing quality and performances of the porous tablets were confirmed to be highly compliant with the pharmacopeia requirement. The level of infill density of the porous tablets had a significant effect on their in vitro drug release performance. Conclusion This is the first report of thermal droplet deposition printing via direct granule feeding. The results of this study demonstrated that this new printing method can be used as a potentially valuable alternative for decentralised pharmaceutical solid dosage form manufacturing.

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“…At its inception, 3DP resulted in a burst of innovation, promise, and action, followed by a realisation of the challenges of its widespread adoption [1][2][3][4]. Significant interest around pharmaceutical 3DP began towards the turn of the century, at a time when the paradigm was the conventional, large-scale mass manufacturing of identical dosage forms [5][6][7]. This inflexible model of medicine offered simplicity and safety, although it often left groups of patients with special pharmaceutical needs, such as the elderly and paediatrics, overlooked and unprovided for [8][9][10].…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Development of immediate release (IR) 3D-printed oral dosage forms with focus on industrial relevance

Cited by 41 publications

References 27 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Direct Granule Feeding of Thermal Droplet Deposition 3D Printing of Porous Pharmaceutical Solid Dosage Forms Free of Plasticisers

Disrupting 3D printing of medicines with machine learning

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