Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository

Choi, Han‐Gon; Jung, Jae Hee; Ryu, Jei-Man; Yoon, Sung-June; Oh, Yu‐Kyoung; Kim, Chong‐Kook

doi:10.1016/s0378-5173(97)00386-4

Cited by 235 publications

(154 citation statements)

References 10 publications

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“…It is to be noticed that, PEG-based suppositories had signifi cantly higher dissolution rates of fenoterol HBr than any poloxamer-based suppositories ( Figures 1A and 1B). These results suggested that PEG was soluble in the dissolution medium, while poloxamer was not soluble but rather gelled (18). The formed gel neither absorbed water nor was it hydrophilic.…”

Section: Kinetic Analysis Of the Release Datamentioning

confidence: 70%

Preparation and evaluation of fenoterol hydrobromide suppositories

Ghorab

Refai

Tag

2011

DD&T

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Section: Kinetic Analysis Of the Release Datamentioning

confidence: 70%

Preparation and evaluation of fenoterol hydrobromide suppositories

Ghorab

Refai

Tag

2011

DD&T

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“…Thermosensitive and mucoadhesive gel formulations were prepared according to the cold method (Choi et al, 1998). Mucoadhesive polymer, Carbopol 934 (Sigma-Aldrich, Bengaluru, India) (0.2% w/v) was slowly added to citrate phosphate buffer (0.1 M, pH 4.0) at 4 C with gentle mixing for 3 h and allowed to hydrate.…”

Section: Development Of Mucoadhesive and Thermo Sensitive Gel Incorpomentioning

confidence: 99%

A vaginal drug delivery model

et al. 2016

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Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and successfully deliver molecules like itraconazole through SLNs. Optimized SLNs with the given composition was selected for further development into mucoadhesive and thermosensitive gel. Stearic acid and Compritol 888 (1:1, w/w ratio) as lipid, a mixture of 3% Poloxomer 188 and 0.5% sodium taurocholate as surfactant and organic to aqueous ratio of 10:50 was taken. Carbopol 934 and Pluronic F 127 were taken for the development of gel. Optimized gel exhibited a desired gelling temperature (35 C); viscosity (0.920 PaS) and appreciable in vitro drug release (62.2% in 20 h). MTT assay did not show any cytotoxic effect of the gel. When evaluated in vivo, it did not exhibit any irritation potential despite appreciable bioadhesion. A remarkable decrease in CFUs was also observed in comparison with control and marketed formulation when evaluated in rat infection model. Thus, the proposed study defines the challenges for developing a suitable formulation system overcoming the delivery barriers of the vaginal site.

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“…Formulation codes of the gels are provided in Table 1. 8,11,12,19,24 Physicochemical characterization of the nasal gels Determination of viscosity Viscosities of different formulations were measured with the same viscometer at five different speeds of 10, 20, 30, 60 and 100 rpm, respectively, using spindle M4 and cord no. 23 at 34 ± 1°C.…”

Section: Preparation Of Mucoadhesive Nasal Gel Of Alprazolammentioning

confidence: 99%

Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics

Roy¹,

Haldar²,

Chhetri³

2016

JYP

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Objective: The objective of the present study was to prepare mucoadhesive in situ nasal gels with mucilage isolated from hibiscus flower (Hibiscus rosa sinensis, family: malveceae) containing alprazolam. Methods-Nasal gels of alprazolam were prepared using three different concentration (0.5%, 1% and 1.5% w/v) of H Rosa mucilage (HRM) and synthetic polymers (Hydroxy propyl methyl cellulose and carbopol 934). In situ gels were prepared with mixture of pluronic F127 and mucoadhesive agent. Result: Evaluation of HRM showed that it was as safe as the synthetic polymer for nasal administration. Evaluation of the prepared gel was carried out, including determination of viscosity, texture profile analysis and mucoadhesive strength. In vitro drug permeation study was conducted with the gels prepared with and without permeation enhancer (0.5% w/v sodium taurocholate) using excised goat nasal mucosa. For the determination of any further histological changes, before and after in vitro permeation study of the gels, with and without the permeation enhancer was also conducted. In vivo experiment conducted in rabbits further confirms that in situ nasal gel prepared with HRM provided better bioavailability of alprazolam than the gels prepared from synthetic mucoadhesive polymer. Conclusion: It was observed that the nasal gel containing 0.5% HRM and 0.5% sodium taurocholate exhibited appropriate rheological, mechanical and mucoadhesive properties and showed better drug release profile. More over this formulation produced no damage to the nasal mucosa used for the permeation study, and absolute bioavailability was also higher compare to gels prepared from synthetic polymers.

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Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository

Cited by 235 publications

References 10 publications

Preparation and evaluation of fenoterol hydrobromide suppositories

Preparation and evaluation of fenoterol hydrobromide suppositories

A vaginal drug delivery model

Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics

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