Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Abstract

Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

A Supine Position and Dual-Dose Applications Enhance Spray Dosing to the Posterior Nose: Paving the Way for Mucosal Immunization

“…As a result, more doses would be deposited in the vestibule and anterior turbinate in comparison to formulations with lower viscosities [ 35 , 36 ]. Viscosity modifiers, such as mucoadhesive polymers, have often been added to nasal spray formulations to improve local delivery or cellular uptake [ 37 , 38 ]. In this study, saline solution was used that had a lower viscosity, which was expected to yield more distal deposition in the nose than using actual nasal formulations.…”

Mechanical and Surface Properties of Edible Coatings Elaborated with Nanoliposomes Encapsulating Grape Seed Tannins and Polysaccharides

“…The lowest value was obtained by HPMC, which is related to the quantity of hydroxyl and methyl groups present in the molecule. This variation can affect density due to changes in the average molecular mass [ 54 ]. When comparing the film-forming suspensions, the structure of kappa carrageenan might lead to more significant swelling than HPMC, potentially contributing to the higher density of KCG [ 55 ].…”

Sprayable adhesive glycopolymer hydrogels with rapid in-situ gelation

“…7 Thermosensitive block copolymers, such as poly(ethylene oxide)-poly( propylene oxide)-poly(ethylene oxide) (i.e., pluronic F-127), can be sprayed in the liquid form at 20 °C and undergo in situ gelation around body temperature. 8 However, this temperature dependent phase-tran-sition typically takes 2-3 minutes to occur, yielding a physical gel with insufficient mechanical strength that drips before gelation. [9][10][11] A UV-triggered design starts with a sprayable formulation of precursor solution containing polymer with vinyl residues and a photo initiator, and the sol-gel transition occurs on the target surface by exposure to UV light.…”