Development of inhalable cubosome nanoparticles of Nystatin for effective management of Invasive Pulmonary Aspergillosis

Kazi, Marzuka; Dehghan, Mohamed Hassan

doi:10.26650/istanbuljpharm.2020.0006

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…With increasing drug concentration, there were significant increase ( ** p < 0.01) in EE% and DL%; as observed with F12 (86.60 ± 1.97%, 4.93 ± 0.11%) and F1(93.95 ± 0.49%, 8.57 ± 0.04%), while with further increase in drug level to 0.35% the reverse effect was obtained significantly ( * p < 0.05) between F11 (81.80 ± 1.50%) and F1 (Tables 1 , 2 ) and precipitation was noticed with drug concentration 0.5% (F10), This was caused by excessive drug levels disrupting the cubic phase's consistency 40 .…”

Section: Resultsmentioning

confidence: 89%

“…These results are due to the unique cubic nanoparticle structure that incorporates lipophilic medicines in the 3-D network of lipid bilayers, which grow in number as the concentration of GMO rises. So more barrier against drug release 40 , 43 , 44 . However, there was no significant effect of tested polymer concentrations (F1 (0.5% F 127 , 2% GMO), F4 (1% F 127 , 2% GMO) and F7 (1.5% F 127 , 2% GMO) on drug release, as the percent of drug released was 21.58 ± 0.04% over 48 h (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect

Ahmed,

Hassanein,

Mohamed

et al. 2023

Sci Rep

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Wound healing is one of the most challenging medical circumstances for patients. Pathogens can infect wounds, resulting in tissue damage, inflammation, and disruption of the healing process. Simvastatin was investigated recently, as a wound healing agent that may supersede the present therapies for wounds. Our goal in this paper is to focus on formulation of simvastatin cubosomes for topical delivery, as a potential approach to improve simvastatin skin permeation. By this technique its wound healing effect could be improved. Cubosomes were prepared using the top-down method and the prepared cubosomes were characterized by several techniques. The most optimal simvastatin cubosomal formulation was then included in a cubogel dosage form using different gelling agents. The results showed that the average particle size of the prepared cubosomes was 113.90 ± 0.58 nm, the entrapment efficiency was 93.95 ± 0.49% and a sustained simvastatin release was achieved. The optimized formula of simvastatin cubogel displayed pseudoplastic rheological behavior. This same formula achieved enhancement in drug permeation through excised rat skin compared to free simvastatin hydrogel with flux values of 46.18 ± 2.12 mcg cm−2 h−1 and 25.92 ± 3.45 mcg cm−2 h−1 respectively. Based on the in-vivo rat studies results, this study proved a promising potential of simvastatin cubosomes as wound healing remedy.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect

Ahmed,

Hassanein,

Mohamed

et al. 2023

Sci Rep

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“…To entrapment efficiency of DOX-CBs, the methods previously reported by Cytryniak et al and Kazi et al 12,19 with minimal modifications. Free DOX from DOX-CBs were obtained by centrifugation for 30 min at 12,000 rpm.…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Almoshari¹,

Alam²,

Bakkari³

et al. 2022

IJPER

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Background: Colorectal cancer (CRC) has grown to be the world's fourth-biggest cause of cancer-related mortality. It is critical to identify more effective treatment options for it. Objectives: Doxorubicin a potent antineoplastic agent is widely used but has severe adverse effects. Therefore, our objective is to use cubosome as an efficient drug delivery system to reduce the off-target effects and increase the cytotoxic effects in CRC cells. Materials and Methods: Pluronic F127-Based Cubosomes were prepared by low energy stirring method and loaded with doxorubicin. Physicochemical characteristics were studied using X-ray diffraction, dynamic light scattering, microscopic techniques, FTIR UV spectrophotometer, and entrapment efficiency. In vitro activity of doxorubicin-loaded cubosomes was studied on HCT-116 cells. Results: The prepared cubosomes have the required nano-size and the FTIR results showed the presence of both doxorubicin and Pluronic F-127. The entrapment efficiency of doxorubicin was high too. DOX-CBs have a better cytotoxic effect and induced ROS and reduced NO levels in HCT-116 cells. Conclusion:The obtained results show that doxorubicin-loaded cubosomes can be used to increase the cytotoxic effect in CRC cells and can be used with other chemotherapeutic agents.

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“…To assess likely interactions between the single ingredient and the mix, FTIR spectroscopy and DSC studies were utilized to look at individual and actual blends in different combinations [12,13]. For DSC examination, 40 µL standard aluminum crucibles that were vacant and pleated were warmed to temperatures somewhere in the range of 30 and 300 °C at a heating pace of 10 °C/min utilizing an intensity DSC-60.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir) and Different...mentioning

confidence: 99%

Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD

THOUTREDDY,

GSN,

MALOTHU

et al. 2023

jrp

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Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs. Transdermal delivery of cubosomes is currently gaining more importance over conventional topical delivery of drugs. The proposed study aimed to produce Lidocaine hydrochloride loaded cubosomes. This study was designed to prepare various formulations of Lidocaine nano cubsomal dispersions at different concentrations of lipid and stabilizer using optimization technique. For the purpose of prolonging the duration of the local anaesthetic action, Lidocaine-loaded cubosomes were developed by bottom up method utilizing Glyceryl mono oleate and Poloxamer 407 in various ratios using the "Quality by Design" approach, 3 2 factorial design employing statistical software. Within the confidence intervals, the 3 2 statistical design was effective at forecasting the optimized formulation's composition. Surface morphology, particle size, drug content, poly dispersibility index, zeta potential, entrapment efficiency, and in vitro drug release studies were conducted on the prepared formulations. Several mathematical models were used to conduct and assess an in vitro drug release investigation. The maximal entrapment efficiency for the LH8 formulation, which was validated to have optimum cubosomes dispersion, was reported to be 78 % with vesicle size as 150 nm, Zeta potential 21.5 mV and Poly Dispersibility Index as 0.08 along with an in vitro drug release 80.03 % by the end of 24 hours. A stable dispersion with appreciable results of evaluation parameters of cubosomal dispersion was conferred with formulation LH8. Hence from amongst the nine formulations developed, it is concluded that LH8 is selected as the optimized dispersion to be incorporated into a gel formulation.

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Development of inhalable cubosome nanoparticles of Nystatin for effective management of Invasive Pulmonary Aspergillosis

Cited by 6 publications

References 3 publications

Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect

Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD

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