Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa

Glieca, Stefania; Quarta, Eride; Bottari, Benedetta; Bancalari, Elena; Monica, Saverio; Scaltriti, Erika; Tambassi, Martina; Flammini, Lisa; Bertoni, Simona; Bianchera, Annalisa; Fainardi, Valentina; Esposito, Susanna; Pisi, Giovanna; Bettini, Ruggero; Sonvico, Fabio; Buttini, Francesca

doi:10.1016/j.ijantimicag.2023.107001

International Journal of Antimicrobial Agents

2024

DOI: 10.1016/j.ijantimicag.2023.107001

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Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa

Stefania Glieca,

Eride Quarta,

Benedetta Bottari

et al.

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2024

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Cited by 6 publications

References 34 publications

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The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract

Glieca,

Quarta,

Bottari

et al. 2024

Expert Opinion on Drug Delivery

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The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract

Glieca,

Quarta,

Bottari

et al. 2024

Expert Opinion on Drug Delivery

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Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

Zhang,

Li,

Sun

et al. 2024

Mediators of Inflammation

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Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little is known about the regulatory effect of lung Lactobacillus and its mechanism in BPD. This study explored the effect of L. reuteri on hyperoxia‐induced mice lung injuries and examined whether L. reuteri played a role via the IL‐22/STAT3 pathway. We found that the intranasal administration of L. reuteri and its tryptophan metabolite indole‐3‐aldehyde (3‐IAld) ameliorated hyperoxia‐induced mice lung BPD‐like changes, deceased proinflammatory cytokines (IL‐1β, IL‐6, and TNF‐α), and increased the levels of surfactant‐associated protein C (SPC), aquaporin 5 (AQP5), and vascular endothelial growth factor receptor 2 (VEGFR2, also known as FLK‐1). Furthermore, L. reuteri and 3‐IAld increased the expression of IL‐22. IL‐22 was also confirmed to ameliorate hyperoxia‐induced mice lung pathological changes, and the protective effects of L. reuteri could be inhibited by anti‐IL‐22 neutralizing antibody. Finally, we confirmed STAT3 activation by IL‐22 in MLE‐12 cells. In summary, our study confirmed L. reuteri alleviated hyperoxia‐induced lung BPD‐like changes in mice by activating the IL‐22/STAT3 signaling pathway via IL‐22 production. Probiotics Lactobacillus is a potential treatment for hyperoxia‐induced lung injury in newborns.

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Quality by Design in Pulmonary Drug Delivery: A Review on Dry Powder Inhaler Development, Nanotherapy Approaches, and Regulatory Considerations

Sutar,

Verma,

Shukla

2024

AAPS PharmSciTech

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Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa

Cited by 6 publications

References 34 publications

The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract

The role of airways microbiota on local and systemic diseases: a rationale for probiotics delivery to the respiratory tract

Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice

Quality by Design in Pulmonary Drug Delivery: A Review on Dry Powder Inhaler Development, Nanotherapy Approaches, and Regulatory Considerations

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