Development of Intracanal Formulation Containing Silver Nanoparticles

Bruniera, João Felipe Bonatto; Silva‐Sousa, Yara Teresinha Corrêa; Lara, Marilisa Guimarães; Pitondo-Silva, André; Marcaccini, Andrea M.; Miranda, Carlos Eduardo Saraiva

doi:10.1590/0103-6440201302431

Cited by 27 publications

(22 citation statements)

References 23 publications

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“…Enterococcus faecalis as the most well-known enterococci species is in charge of almost all persistent periradicular lesions (4,5). Recent studies have reported the excellent antibacterial activity of different synthesized AgNPs against planktonic E. faecalis (29)(30)(31). However, these studies were limited by the lack of investigation on antimicrobial properties of these nanoparticles against the biofilm E. faecalis.…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm Efficacy of Positively Charged Imidazolium-Based Silver Nanoparticles in Enterococcus faecalis Using Quantitative Real-Time PCR

Nabavizadeh

Abbaszadegan

Gholami

et al. 2017

Jundishapur J Microbiol

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Background: Nanoparticles are made by different methodologies, which can affect the particle's features. Recently, imidazoliumcoated silver nanoparticles with a positive surface charge (PC Im-based AgNPs) have revealed favorable results as a root canal disinfectant. However, the antibacterial potency of these particles against biofilm form of Enterococcus faecalis, as the most resistant organism to eliminate in endodontic treatment, has not been investigated. It can be noted that removing this microorganism is associated with extremely effective disinfection. Objectives: This study investigated the antibacterial efficacy of PC Im-based AgNPs at 5.7 × 10-8 mol L-1 in comparison with 2.5% sodium hypochlorite (NaOCl) and 2% chlorhexidine as the two broadly used endodontic irrigation solutions against biofilm E. faecalis using quantitative real-time polymerase chain reaction. Methods: In total, 48 premolar teeth with a single root were infected with E. faecalis and then prepared with ProTaper rotary instruments. The samples were randomly allocated into 4 groups of 12 samples. Sterile saline, PC Im-based AgNPs, NaOCl, and chlorhexidine were used as irrigants. Sampling the root canals was implemented with paper points and Gates-Glidden drills. The reduction in E. faecalis counts was calculated and statistically analyzed by means of the Kruskal-Wallis and Mann-Whitney U tests. Results: Irrigation with PC Im-based AgNPs or NaOCl was significantly more effective in bacterial count reduction compared to irrigation with chlorhexidine or sterile saline (P < 0.05). There was no significant difference between PC Im-based AgNPs and NaOCl irrigants when either Gates-Glidden drills (P = 0.751) or paper points (P = 0.488) were employed. Chlorhexidine was significantly less efficient than PC Im-based AgNPs and NaOCl solutions (P < 0.001); however, it was significantly better than sterile saline in both sampling approaches (P > 0.001). Conclusions: The PC Im-based AgNP solution revealed promising results as a root canal irrigant. This solution at 5.7 × 10-8 mol L-1 was effectively able to eliminate biofilm E. faecalis and this was not significantly different from that of 2.5% NaOCl.

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Section: Discussionmentioning

confidence: 99%

Antibiofilm Efficacy of Positively Charged Imidazolium-Based Silver Nanoparticles in Enterococcus faecalis Using Quantitative Real-Time PCR

Nabavizadeh

Abbaszadegan

Gholami

et al. 2017

Jundishapur J Microbiol

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“…The sustained action was absent for both NaOCl and CHX. Bruniera et al developed silver nanoparticles that were transported in to the root canal using a hydroxyethylcellulose polymer gel . The formulation was bactericidal to several species (found within root canal systems) including Escherichia coli, E. faecalis, Pseudomonas aeruginosa, and Streptococcus mutans .…”

Section: Endodontic Materialsmentioning

confidence: 99%

“…Bruniera et al developed silver nanoparticles that were transported in to the root canal using a hydroxyethylcellulose polymer gel. 72 The formulation was bactericidal to several species (found within root canal systems) including Escherichia coli, E. faecalis, Pseudomonas aeruginosa, and Streptococcus mutans. In addition, the authors claimed that the fluidity and homogeneity of the formulation would allow for penetration into the dentinal tubules.…”

Section: Irrigationmentioning

confidence: 99%

Oroactive dental biomaterials and their use in endodontic therapy

et al. 2019

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Dental biomaterials have revolutionized modern therapies. Untreated dental caries remains the major etiological factor for endodontic treatment, and together with a decreasing rate of tooth loss escalates the importance of continuously improving the materials used for endodontic therapies. Endodontic biomaterials are used for vital pulp therapies, irrigation, intracanal medicaments, obturation and regenerative procedures. These materials offer several functions including: antimicrobial activity, mechanical reinforcement, aesthetics, and therapeutic effects. Vital pulp therapies have seen an improvement in clinical results with an incremental approach to build on the strengths of past materials such as calcium hydroxide and calcium silicates. While sodium hypochlorite remains the gold standard for canal irrigation, numerous nanoparticle formulations have been developed to promote sustained antimicrobial action. Gutta‐percha based bulk fillers remain the most common materials for root filling. However, while multiple studies focus on the development of novel formulations containing drugs, glass derivatives or ionic‐, polymeric‐, or drug‐ loaded nanoparticles, a lack of reliable and long‐term clinical evidence obligates further study as experienced clinicians prefer to use what has worked for decades. This review delves in to the biochemistry of the materials to scrutinize their shortcomings, and where opportunity lies to further enhance their efficacy in endodontic practice. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:201–212, 2020.

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“…Chlorhexidine-loaded polymeric nanocapsule with superior antimicrobial activity was developed by interfacial deposition method [45]. Solid lipid nanoparticles of silver showed better antiseptic activity [46].…”

Section: Nanomaterials In Antisepticsmentioning

confidence: 99%

Nanotechnology: A Modern Contraption in Cosmetics and Dermatology

Sharma

Singh

Kanojia

et al. 2018

ACCTRA

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Background: Nanoscience is the section of science related to the study of minute particles on an atomic or molecular scale, whose size is measured in nanometres. Nanotechnology serves as one of the most capable technologies and accomplished approaches of the 21 st century which is safe and efficacious for novel drug delivery systems. Now, nanotechnology is used widely in the field of cosmetics and dermatology due to the improved properties of the atoms at the nano level. Objectives: This mini-review article has been planned to discuss basic facts regarding nanotechnology as well as various nanotechnology drug delivery systems used in cosmetics and dermatology, applications of nanotechnology and overview of patents published recently in the field of nanocosmetics. The current status of regulatory as well as safety and quality aspects for the use of nanotechnology in cosmetics and dermatology will also be discussed. Discussion: Cosmetics industry is the sixth largest industry among United States patent holders in nanotechnology. Nanotechnology has transfigured the treatment of several skin diseases. Possible applications of nanotechnology in dermatology and cosmetology include sunscreens, moisturizers, anti-aging formulations, anti-sepsis, nails and hair care. The recent studies to date suggest that the nano-cosmeceuticals have no safety issues with skin as well as human health, although the nano-cosmeceuticals are beneficial for human health in a number of ways such as guarding against UV rays which may cause skin cancer. The regulatory bodies had performed an active debate on the potential risk of nano-cosmeceuticals on human health and steps have been taken for thecoordination of regulatory rules.

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Development of Intracanal Formulation Containing Silver Nanoparticles

Cited by 27 publications

References 23 publications

Antibiofilm Efficacy of Positively Charged Imidazolium-Based Silver Nanoparticles in Enterococcus faecalis Using Quantitative Real-Time PCR

Antibiofilm Efficacy of Positively Charged Imidazolium-Based Silver Nanoparticles in Enterococcus faecalis Using Quantitative Real-Time PCR

Oroactive dental biomaterials and their use in endodontic therapy

Nanotechnology: A Modern Contraption in Cosmetics and Dermatology

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