Development of intranasal implantable devices for schizophrenia treatment

Utomo, Emilia; Domínguez-Robles, Juan; Moreno-Castellanos, Natalia; Stewart, Sarah A.; Picco, Camila J.; Anjani, Qonita Kurnia; Simón, Jon Ander; Peñuelas, Iván; Donnelly, Ryan F.; Larrañeta, Eneko

doi:10.1016/j.ijpharm.2022.122061

Cited by 31 publications

(16 citation statements)

References 64 publications

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“…Differences of 1.2 cm −1 and 1.6 cm −1 at 3400 and 1670, respectively, maybe ascribed the hydrogen bonding or dipolar interactions. 55,56…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…59 The release exponent value of FUR-MN2 and FUR-MN3 was approximately 0.5 implying that FUR release is mainly governed by drug diffusion, while FUR-MN4 exhibited a higher n value ( n = 0.801) indicating that the drug release was driven by diffusion and partial relaxation of the polymer. 56 A swelling test was performed for FUR-MN2 over 48 h, the duration of the release experiment. After initial slight swelling and relaxation, the swelling ratio remained constant for the last 42 h and no weight loss was measured.…”

Section: Resultsmentioning

confidence: 99%

“…Differences of 1.2 cm −1 and 1.6 cm −1 at 3400 and 1670, respectively, maybe ascribed the hydrogen bonding or dipolar interactions. 55,56 To evaluate the potential application of FUR-loaded MNs, in vitro release of FUR from FUR-MN2, FUR-MN3 and FUR-MN4 was tested in PBS pH 7.4 at 37 °C, where sink conditions were maintained. FUR release from MNs exhibits an initial burst release accompanied by a sustained release phase…”

Section: Papermentioning

confidence: 99%

“…In addition, when drug molecules incorporated into the surface of the polymer matrix dissolve into the release medium, they leave pores via which medium can enter the polymer network and facilitate further drug release. 56,58 The data obtained from in vitro release studies were fit to zero-order, first-order and Korsmeyer-Peppas release kinetics models in an attempt to elucidate the release mechanism. The correlation coefficient (R 2 ) values for the kinetic models are displayed in Table 4, showing that the data best fit first-order release and Korsmeyer-Peppas model.…”

Section: Biomaterials Science Papermentioning

confidence: 99%

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Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

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“…Differences of 1.2 cm −1 and 1.6 cm −1 at 3400 and 1670, respectively, maybe ascribed the hydrogen bonding or dipolar interactions. 55,56…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

Section: Biomaterials Science Papermentioning

confidence: 99%

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Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

et al. 2022

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Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture‐Indicating Silica

Li,

Anjani,

Hutton

et al. 2024

Adv Healthcare Materials

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Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end‐user surveys have hindered their commercialization efforts. One prevalent issue highlighted in these surveys is the lack of clear indicators for successful patch insertion and removal time. To address this challenge, a color‐change‐based feedback system is devised, which confirms the insertion and dissolution of DMAPs, aiming to mitigate the aforementioned problems. The approach combines hydrophilic needles containing model drugs (fluorescein sodium and fluorescein isothiocyanate (FITC)‐dextran) with a hydrophobic poly(lactic acid) baseplate infused with moisture‐sensitive silica gel particles. The successful insertion and subsequent complete dissolution of the needle shaft are indicated by the progressive color change of crystal violet encapsulated in the silica. Notably, distinct color alterations on the baseplate, observed 30 min and 1 h after insertion for FITC‐dextran and fluorescein sodium DMAPs respectively, signal the full dissolution of the needles, confirming the complete cargo delivery and enabling timely patch removal. This innovative feedback system offers a practical solution for addressing end‐user concerns and may significantly contribute to the successful commercialization of DMAPs by providing a visualized drug delivery method.

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Differences between criminal offender versus non-offender female patients with schizophrenia spectrum disorder: a retrospective cohort study

Jacobshagen,

Machetanz,

Kirchebner

2024

Arch Womens Ment Health

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The purpose of this study was to investigate the difference between offender female patients (OFS) and non-offender female patients (NOFS) with schizophrenia spectrum disorder (SSD).The patients in this study were admitted to the university psychiatry in Zurich Switzerland between 1982 and 2016. Demography, psychopathology, comorbidity, and treatment differences were analyzed using binary statistics to compare 31 OFS and 29 matching NOFS with SSD. The Fisher‘s exact test was used for categorical data variables in small size samples and the Mann-Whitney-U-Test for nonparametric test variables, adjusted with the Benjamini and Hochberg method.The results indicate that the NOFS were cognitively more impaired, they were more likely to have had antipsychotic drugs prescribed (NOFS; 100%, OFS: 71%, OR 1.41, 95% CI 1.13-1.77, p=0.022) and their medication compliance was higher (NOFS: 84.6%, OFS: 4.5%, OR 0.09, 95% CI 0.00-0.08, p=0.000). In contrast, the OFS had completed compulsory school less often and the were observed to be more often homeless and socially isolated (OFS: 72.4%, NOFS: 34.6%, OR 4.96, 95% CI 1.58-15.6, p=0.026), self-disorders (OFS: 51.6%, NOFS: 11.1%, OR 8.53, 95% CI 2.12-34.32, p=0.011), delusions (OFS: 96.8%, NOFS: 63%, OR 17.65, 95% CI 2.08-149.99, p=0.014) and substance use disorder (51.6%, OR 0.27, 95% CI 0.09-0.85, p=0.039). Clinicians treating female offender patients with SSD should focus more on the treatment for substance use disorder, medication and early recognition of the illness for preventative purposes.

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Development of intranasal implantable devices for schizophrenia treatment

Cited by 31 publications

References 64 publications

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture‐Indicating Silica

Differences between criminal offender versus non-offender female patients with schizophrenia spectrum disorder: a retrospective cohort study

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