Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing

Okuma, Cindy Hana; Andrade, Thiago Antônio Moretti de; Caetano, Guilherme Ferreira; Finci, Lorenzo I.; Maciel, Naira Rezende; Topan, José Fernando; Cefali, Letícia Caramori; Polizello, Ana Cristina Morseli; Carlo, Troy; Rogério, Alexandre de Paula; Spadaro, Augusto César Cropanese; Isaac, Vera Lúcia Borges; Frade, Marco Andrey Cipriani; Rocha‐Filho, Pedro Alves da

doi:10.1016/j.ejps.2015.01.016

Cited by 45 publications

(15 citation statements)

References 35 publications

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“…In fact, A. vera , C. officinalis and P. americana were found to show no trace of cytotoxicity after 24 hrs when tested in the brine shrimp lethality assay. The low cytotoxicity shown by S. chinensis and C. officinalis has also previously been observed [17, 19]. The cytotoxicity of H. perforatum, P. americana, and P. armeniaca carrier oils, however, is reported for the first time in this study.…”

Section: Resultssupporting

confidence: 67%

“…It is known that the chemical composition of essential oils may vary due to differences in chemotype, storage, harvesting, or plant origin [13–15]. For example, the sample of Thymus vulgaris from this study has a lower content of thymol (18.9%) than reported in previous studies (44.7-48.9%) [16–18] and the Laurus nobilis sample used in this study contains myrcene and chavicol, as opposed to high levels of 1,8-cineole (35.5-42.3%) as previously reported [19, 20]. Five out of the six carrier oils contained both linoleic acid and oleic acid methyl esters (Table 2).…”

Section: Resultssupporting

confidence: 65%

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The Influence of Carrier Oils on the Antimicrobial Activity and Cytotoxicity of Essential Oils

Orchard

Kamatou

Viljoen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The topical use of essential oils requires dilution into a carrier oil; however, scientific evidence regarding the antimicrobial efficacy and cytotoxicity when a carrier oil is combined with an essential oil is lacking. This study sets out to determine the antimicrobial activity and cytotoxicity of 23 essential oils combined with six known carrier oils. Gas chromatography-mass spectrometry/flame ionization detector (GC-MS/FID) was used to characterize the methyl esters of the carrier oils. The antimicrobial activity of the carrier oils alone and in combination with the essential oils was investigated using the broth microdilution assay against 11 skin pathogens and the cytotoxicity was determined using the brine shrimp lethality assay. The interactive profiles of the combinations for both antimicrobial activity and the cytotoxicity were analysed and calculated using the fractional inhibitory concentration index (ΣFIC). The carrier oils demonstrated no antimicrobial antagonism when combined with the essential oils and the overall cytotoxicity of the majority of the combinations was decreased. The carrier oils that could be identified as enhancing the antimicrobial activity and decreasing the cytotoxicity were Aloe vera Mill. and Simmondsia chinensis C.K.Schneid (Jojoba oil), with an overall reduction in essential oil cytotoxicity of 87.5% at 24 hrs and 85% at 48 hrs by A. vera. Five of the essential oils (when diluted in A. vera and S. chinensis carrier oils) demonstrated enhanced antimicrobial activity against pathogens such as Brevibacterium epidermidis, B. linens, and P. aeruginosa with MIC values ranging from 0.09 to 0.50 mg/mL (and ΣFIC 0.14-0.39). The study could conclude that the carrier oils are complementary to essential oil formulations, mostly reducing cytotoxicity and in some cases enhancing the antimicrobial activity.

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Section: Resultssupporting

confidence: 67%

Section: Resultssupporting

confidence: 65%

The Influence of Carrier Oils on the Antimicrobial Activity and Cytotoxicity of Essential Oils

Orchard

Kamatou

Viljoen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Compared with traditional dressings, modern dressings are characterized by better biocompatibility, degradability, and moisture retention. These advantages of modern dressings relieve pain and improve the hypoxic or anaerobic environment (Hopper et al, 2012;Thu et al, 2012;Okuma et al, 2015). The most commonly used modern dressings in clinical practice are hydrogels, hydrocolloid, alginates, foams, and films ( Table 1).…”

Section: Wound Dressingsmentioning

confidence: 99%

Selection of Appropriate Wound Dressing for Various Wounds

Shi

Wang

et al. 2020

Front. Bioeng. Biotechnol.

316

157

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There are many factors involved in wound healing, and the healing process is not static. The therapeutic effect of modern wound dressings in the clinical management of wounds is documented. However, there are few reports regarding the reasonable selection of dressings for certain types of wounds in the clinic. In this article, we retrospect the history of wound dressing development and the classification of modern wound dressings. In addition, the pros and cons of mainstream modern wound dressings for the healing of different wounds, such as diabetic foot ulcers, pressure ulcers, burns and scalds, and chronic leg ulcers, as well as the physiological mechanisms involved in wound healing are summarized. This article provides a clinical guideline for selecting suitable wound dressings according to the types of wounds.

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“…Foram demonstradas atividades antibacterianas em endodontia para a espécie Arctium lappa (bardana) 14, 15 . A aplicação tópica de gel elaborado a partir do óleo de Calendula officinalis (calêndula) demonstrou capacidade de reepitelização e cicatrização de feridas 16 . Por sua vez, a pomada elaborada com o extrato de Melia azedarach (cinamomo) mostrou ação antibacteriana e anti-inflamatória em feridas incisionais, as quais cicatrizaram em torno de 15 dias 17 .…”

Section: Metodologiaunclassified

Uso popular de plantas medicinais na cicatrização de feridas: implicações para a enfermagem

et al. 2015

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RESUMO: Este estudo teve como objetivo identificar as plantas medicinais indicadas por informantes folk do sul do Brasil para o tratamento de feridas, explicitando as implicações para a prática profissional da enfermagem. Trata-se de estudo qualiquantitativo, descritivo, realizado em quatro municípios do sul do Brasil. Foi realizada entrevista semiestruturada gravada, com georreferenciamento dos locais de coleta, observação sistemática e registro fotográfico das plantas medicinais. Foram entrevistados 10 informantes, entre setembro de 2009 e agosto de 2011. Os resultados evidenciaram a indicação de 19 plantas medicinais para o tratamento de feridas. Destas, 16 possuem efeitos cicatrizantes relatados na literatura científica. Assim, a enfermagem, profissão que valoriza o cuidado às feridas, necessita entender como este cuidado é prestado popularmente, para que o enfermeiro torne-se sujeito ativo na recuperação da saúde da população atendida. Palavras-Chave: Fitoterapia; cuidados de enfermagem; medicina tradicional; cicatrização. ABSTRACT: A qualitative and quantitative, descriptive study was conducted in four cities in southern Brazil to identify the medicinal plants indicated by folk informants for treating wounds, and the implications for professional nursing practice. Between September, 2009 and August, 2011, semi-structured interviews of ten informants were recorded, medicinal plant collection sites were georeferenced, with systematic observation, and photographic records were made. Results showed that 19 medicinal plants were being indicated for treating wounds. Of these, the healing effects of 16 are reported in the scientific literature. Accordingly, nursing, a profession that appreciates the importance of caring for wounds, should understand how this care is provided traditionally, in order for nurses to become active subjects in restoring health in the population served.

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Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing

Cited by 45 publications

References 35 publications

The Influence of Carrier Oils on the Antimicrobial Activity and Cytotoxicity of Essential Oils

The Influence of Carrier Oils on the Antimicrobial Activity and Cytotoxicity of Essential Oils

Selection of Appropriate Wound Dressing for Various Wounds

Uso popular de plantas medicinais na cicatrização de feridas: implicações para a enfermagem

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