Development of Lesions in Syrian Golden Hamsters Following Exposure to Radon Daughters and Uranium Ore Dust

Cross, F.T.; Palmer, Robert E. A.; Busch, R. H.; Filipy, R.E.; Stuart, B.O.

doi:10.1097/00004032-198107000-00012

Cited by 35 publications

(14 citation statements)

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“…However, the influence of ROS generated in the cytosol could be sufficient enough to affect the mitochondria. The oxidative stress generated due to loss of antioxidants can be restored by supplementation of antioxidants (13,14). In the present study, we supplemented antioxidants and shown the protection against oxidative stress generated by Uranium.…”

Section: Discussionsupporting

confidence: 49%

Uranyl Nitrate Induced Histological Changes in Lung Tissue

2017

IJIET

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Abstract-Uranium is a naturally occurring radioactive material present everywhere in the environment. It is toxic because of its chemical or radioactive properties. Uranium enters environment mainly from mines and industry and cause threat to human health by accumulating in lungs as a result of inhalation. In our previous study, we have shown the effectiveness of antioxidant system response to the oxidative stress induced by Uranyl Nitrate (UN) in rat lung tissue. In the current study, uranium toxicity was evaluated in rat lung epithelial cells. The study shows uranium nitrate induces significant oxidative stress in rat lung epithelial cells followed by decrease in the antioxidant potential of the cells. Treatment with Uranyl Nitrate to rat lung epithelial cells was attributed to loss of total glutathione, thus the results indicate the ineffectiveness of antioxidant system's response to the oxidative stress induced by uranium in the cells. Histological study show slight degenerative changes in lung, pulmonary edema; hemorrhage; emphysema; inflammation of the bronchi; alveoli and alveolar interstices; edematous alveoli; lung lesions; minimal pulmonary hyaline fibrosis and pulmonary fibrosis.

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Section: Discussionsupporting

confidence: 49%

Uranyl Nitrate Induced Histological Changes in Lung Tissue

2017

IJIET

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“…Chromosomal aberrations were counted as a measure of clastogenic insult and, more recently, the hypoxanthine-guanine phosphoribosyl transferase (HPRT) mutation assay, the most widely used measure of somatic gene mutations in humans (Cole & Skopek 1994;Robinson et al 1994;Albertini & Hayes 1997;Albertini 2001), was added to our test battery. While there is good biologic plausibility for U to be genotoxic, based on animal data (Hueper et al 1952;Leach et al 1973;Cross et al 1981;Mitchell et al 1999;Hahn et al 2002), some epidemiologic data in exposed workers (Martin et al 1991) and, more recently, the evidence reported from in vitro studies (Lin et al 1993;Miller et al 1998bMiller et al , 2002aMiller et al ,b, 2003Yazzie et al 2003;Stearns et al 2005), the results of our studies are mixed. The HPRT frequency results, when analysed using the U low/ high stratified grouping, are not significantly different, although mean mutation frequency (MF) was higher in the high U group in both 2001(McDiarmid et al 2004a,b, 2006).…”

Section: K1mentioning

confidence: 62%

Depleted uranium exposure and health effects in Gulf War veterans

Squibb

McDiarmid

2006

Phil. Trans. R. Soc. B

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Health effects stemming from depleted uranium (DU) exposure in a cohort of Gulf War veterans who were in or on US Army vehicles hit by friendly fire involving DU munitions are being carefully monitored through the Baltimore Veterans Affairs (VA) DU Follow-Up Program initiated in 1993. DU exposure in this cohort has been directly measured using inductively coupled plasma-mass spectrometer (ICP-MS) isotopic analysis for DU in urine specimens. Soldiers with embedded DU fragments continue to excrete elevated concentrations of U in their urine, documenting ongoing systemic exposure to U released from their fragments. Biennial surveillance visits provide a detailed health assessment that includes basic clinical measures and surveillance for early changes in kidney function, an expected target organ for U. Tests also include measurements of genotoxicity and neuroendocrine, neurocognitive and reproductive function. With the exception of the elevated urine U excretion, no clinically significant expected U-related health effects have been identified to date. Subtle changes in renal function and genotoxicity markers in veterans with urine U concentrations greater than 0.1 mg K1 creatinine, however, indicate the need for continued surveillance of these DU-exposed veterans.

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“…In an intermediate-exposure study (15 d to 1 yr), these same scientists reported lung lesions, minimal pulmonary hyaline fibrosis, and pulmonary fibrosis in these animals. In addition, Cross et al (1981) reported slight degenerative changes in the lungs of Syrian golden hamsters as well as pulmonary edema, inflammation of the bronchi, bronchial pneumonia, alveoli and alveolar interstices, hyperemia, and atelectasis. Chronic studies with an exposure duration of over 1 yr demonstrated mild pulmonary fibrosis in rats, and lung cancer in dogs .…”

Section: Pulmonary Toxicitymentioning

confidence: 98%

“…Serum hepatic enzyme concentrations and liver function tests in this patient were reported within normal limits from the time of exposure through a 3-yr follow-up . Cross et al (1981) reported results from an intermediate-duration exposure study in which fatty livers were found in five of the eight Syrian golden hamsters that died during the study. In addition, focal necrosis of the liver was noted in these same animals.…”

Section: Hepatic Toxicitymentioning

confidence: 99%

Depleted and Natural Uranium: Chemistry and Toxicological Effects

Craft

Abu-Qare

Flaherty

et al. 2004

Journal of Toxicology and Environmental Health, Part B

368

231

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Depleted uranium (DU) is a by-product from the chemical enrichment of naturally occurring uranium. Natural uranium isInterest in depleted uranium (DU) is rapidly increasing as researchers realize its many potential military and civilian applications. Uranium, a naturally occurring heavy metal, is found in all soils, waters and rocks. Natural uranium is comprised of three radioactive isotopes: 238 U, 235 U, and 234 U. Of these, 235

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Development of Lesions in Syrian Golden Hamsters Following Exposure to Radon Daughters and Uranium Ore Dust

Cited by 35 publications

References 0 publications

Uranyl Nitrate Induced Histological Changes in Lung Tissue

Uranyl Nitrate Induced Histological Changes in Lung Tissue

Depleted uranium exposure and health effects in Gulf War veterans

Depleted and Natural Uranium: Chemistry and Toxicological Effects

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