2023
DOI: 10.1002/jssc.202300380
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Development of liquid chromatography‐triple quadrupole mass spectrometric method for the quantitative determination of a novel adjuvant, Imidazoquinoline gallamide in aluminum hydroxide gel‐Imidazoquinoline gallamide and COVAXIN

Narendra Kumar Nagendla,
Seetha Bala Subrahanyam,
Satyanand Konda
et al.

Abstract: Imidazoquinoline gallamide is a toll‐like receptor 7/8 agonist, belongs to the imidazoquinoline class, has the potential to activate antigen‐presenting cells, and enhances immune response, primarily Th1 response. The COVAXIN is a whole virion inactivated Coronavirus disease 2019 vaccine formulated with this novel adjuvant called, aluminum hydroxide gel Imidazoquinoline gallamide, wherein, Imidazoquinoline gallamide is chemisorbed onto aluminum hydroxide gel. Herein, an analytical method based on liquid chromat… Show more

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