Development of Listeria Meningitis during Vancomycin Therapy: A Case Report

Baldassarre, James; Ingerman, Mark J.; Nansteel, John; Santoro, Jerome

doi:10.1093/infdis/164.1.221

Cited by 27 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TMP-SMZ is generally recommended for penicillin-allergic patients, [75•,76] because it has good intracellular and CSF penetration. Alternatively, some have suggested vancomycin and an aminoglycoside; however, the development of meningitis during therapy with vancomycin suggests that this is not an optimal regimen [77]. Penicillin desensitization may also be considered in cases of β-lactam allergy.…”

Section: Treatmentmentioning

confidence: 99%

Update on listeria monocytogenes infection

Crum

2002

Curr Gastroenterol Rep

View full text Add to dashboard Cite

Listeria monocytogenes is a gram-positive bacillus that causes meningitis, encephalitis, bacteremia, and febrile gastroenteritis. Most disease occurs in immunosuppressed individuals. Recent seroepidemiologic studies show that the infection is foodborne. Due to the increasing number of immunosuppressed individuals at risk for listeriosis, as well as the persistence of substantial foodborne outbreaks, L. monocytogenes has gained worldwide attention as an important pathogen. Heightened surveillance and quality control by the food industry have been instituted, leading to a reduction in the number of cases and deaths from this infection in the past decade. However, due to the ubiquity of the organism in the environment, outbreaks and sporadic disease continue to occur. The standard therapy for listeriosis is a combination of ampicillin and gentamicin or, for patients who are intolerant of b-lactam agents, trimethoprim-sulfamethazole. Despite the availability of therapy, the mortality rate remains high in those with T-cell immunodeficiencies.

show abstract

Section: Treatmentmentioning

confidence: 99%

Update on listeria monocytogenes infection

Crum

2002

Curr Gastroenterol Rep

View full text Add to dashboard Cite

show abstract

“…Currently available quinolones do not have good in vitro activity. Vancomycin has been used successfully in a few patients with listeriosis who are allergic to penicillin [120,121], but other patients have developed listerial meningitis while receiving the drug [122]. Rifampin is quite active in vitro against L. monocytogenes and is known to penetrate into phagocytic cells; however, the clinical experience is minimal, and the addition of rifampin to ampicillin was not more effective than ampicillin alone in animal models [108].…”

Section: Treatmentmentioning

confidence: 99%

Listeriosis

Lorber

1997

Clinical Infectious Diseases

444

250

View full text Add to dashboard Cite

“…15,16 Vancomycin may be an alternative if meningitis is excluded, as it barely crosses the blood-brain barrier, but clinical failure have been reported despite proven in vitro activity. 15,16,18 Although broad-spectrum antibiotics such as piperacillin/tazobactam or high-dose carbapenems are widely used as empiric therapy for sepsis in vulnerable and immunocompromised patients, they are not considered as optimal empirical therapy for patients at risk of listeriosis since the central nervous system penetration of piperacillin/ tazobactam is not reliable and both clinical failure and increased mortality has been reported in invasive listeriosis patients treated with meropenem. (7,(9)(10)(11)(12)(13)(14).Fluoroquinolones have been highly recommended by some authors.…”

Section: Discussionmentioning

confidence: 99%

Solid organ donation after death from listeria encephalitis: A case report

Douchy¹,

Lagrou

Jochmans

et al. 2020

Transplant Infectious Dis

View full text Add to dashboard Cite

Despite organ shortage, organs from donors with listeria infections have been discarded for transplantation. We present the first‐reported case of liver transplantation following listeria encephalitis. The patient was admitted with progressing neurological symptoms after an episode of gastroenteritis. Rhombo‐encephalitis was diagnosed, and Listeria monocytogenes was found to be the causative pathogen. Despite proper antibiotic treatment and rapid clearance of bacteremia, he continued to deteriorate and became brain dead, after which organ donation was performed. At procurement, he had been treated with amoxicillin for 9 days. The recipient was treated with pipercillin/tazobactam for 21 days. Besides an anastomotic biliary stricture, necessitating endoscopic dilatation and stenting, further clinical course was uneventful and she is doing well eleven months post‐transplant. Our case suggests that listeria encephalitis is not an absolute contra‐indication to solid organ donation. We suggest that donors should be treated with adequate antibiotics for at least 48h prior to procurement and advocate confirmation of sterile blood cultures as a prerequisite for donation. According to listeriosis guidelines, we suggest that the recipient should be treated with targeted antibiotics for at least 2 weeks. The risk of transmission should, however, always be balanced carefully against the suspected waiting list mortality.

show abstract

Development of Listeria Meningitis during Vancomycin Therapy: A Case Report

Cited by 27 publications

References 0 publications

Update on listeria monocytogenes infection

Update on listeria monocytogenes infection

Listeriosis

Solid organ donation after death from listeria encephalitis: A case report

Contact Info

Product

Resources

About