Development of Liver and Pancreas

Eşrefoğlu, Mukaddes; Taşlıdere, Elif; Çetin, Aslı

doi:10.14235/bs.2016.841

Cited by 5 publications

(7 citation statements)

References 39 publications

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“…On the 14 th day, the liver became the most critical bloodforming organ at gestation. This finding concurred with results in rabbits (4), and in mice revealed this result at 10 th -15 th days (24). The ductal plates were formed at this stage.…”

Section: Discussionsupporting

confidence: 93%

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Histogenesis of the rabbit liver (pars hepatica) with particular reference to the portal area

Elsheikh¹,

EL-Hady²,

Abdallah³

et al. 2023

IJVS

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Rabbits are small mammals used as standard lab animals in biomedical research. The liver is the largest internal organ, providing essential metabolic, exocrine, and endocrine functions. The present study was performed on rabbit embryos and fetuses at different gestational periods and neonatal kittens to find out the histological structure of the liver. Histogenesis of the liver was performed by using different histological stains, Harris's H and E and Masson's trichrome. The liver bud was developed around the 10th day of gestation from the caudo-ventral part of the foregut. In comparison, the hepatoblasts developed at the 12th day of gestation. Then, the liver increased in size, and cellular differentiation occurred throughout the entire length of the gestation period. The hepatic parenchymal cells, central vein, and hematopoietic cells were studied for their developmental sequences. The portal area differentiation was the focus of our study. This study clarified that this area was essential for detecting mesenchymal stem cell markers through immunohistochemistry.

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Section: Discussionsupporting

confidence: 93%

“…This result was in line with those found in the rabbit (4). In mice cleared that the liver diverticulum formed at 9 th -9.5 th days of gestation (21)(22)(23)(24). However, mice observed this diverticulum on the 8.5 th day (25).…”

Section: Discussionmentioning

confidence: 99%

Histogenesis of the rabbit liver (pars hepatica) with particular reference to the portal area

Elsheikh¹,

EL-Hady²,

Abdallah³

et al. 2023

IJVS

View full text Add to dashboard Cite

show abstract

“…Although these proteins are well known to be secreted mainly by the liver, our data raise the possibility that the pancreas could also synthesize and secrete them into the bloodstream, although other possible post-transcriptional mechanisms exist. Nonetheless, because the pancreas and liver share a common embryological origin and some histological similarities, it is possible they also have cellular functions in common (Esrefoglu et al, 2016).…”

Section: Rna and Protein Expression Differences Reveal Insights To Protein Secretionmentioning

confidence: 99%

A Quantitative Proteome Map of the Human Body

Jiang

Wang

Lin

et al. 2020

Cell

312

223

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Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes across 32 normal human tissues. Tissue-specific or tissue-enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode tissue-specific proteins. Discordance of RNA and protein enrichment revealed potential sites of synthesis and action of secreted proteins. The tissue-specific distribution of proteins also provides an indepth view of complex biological events that require the interplay of multiple tissues. Most importantly, our study demonstrated that protein tissue-enrichment information can explain phenotypes of genetic diseases, which cannot be obtained by transcript information alone. Overall, our results demonstrate how understanding protein levels can provide insights into regulation, secretome, metabolism, and human diseases.

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“…Although these proteins are well known to be secreted mainly by the liver, our data suggests pancreas may also synthesize and secrete them into the bloodstream. Since the pancreas and liver share a common embryological origin and some histological similarities, it is possible they have some cellular functions in common (22,23).…”

Section: Concordance and Discordance In Secreted Proteinsmentioning

confidence: 99%

A Quantitative Proteome Map of the Human Body

Jiang

Wang

Lin

et al. 2019

Preprint

109

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Quantitative proteome study of 32 human tissues and integrated analysis with transcriptome data revealed that understanding protein levels could provide in-depth knowledge to post transcriptional or translational regulations, human metabolism, secretome, and diseases. AbstractDetermining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins (5,499) were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly tissue specific proteins. Discordance in the sites of RNA expression and protein detection also revealed potential sites of synthesis and action of protein signaling molecules. Overall, these results provide an extraordinary resource, and demonstrate that understanding protein levels can provide insights into metabolism, regulation, secretome, and human diseases.

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Development of Liver and Pancreas

Cited by 5 publications

References 39 publications

Histogenesis of the rabbit liver (pars hepatica) with particular reference to the portal area

Histogenesis of the rabbit liver (pars hepatica) with particular reference to the portal area

A Quantitative Proteome Map of the Human Body

A Quantitative Proteome Map of the Human Body

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