Development of lycopene-based whole-cell biosensors for the visual detection of trace explosives and heavy metals

Li, Meijie; Lv, Shuzhe; Yang, Rumeng; Chu, Xiaohan; Wang, Xu; Wang, Ziyu; Peng, Limin; Yang, Jianming

doi:10.1016/j.aca.2023.341934

Analytica Chimica Acta

2023

DOI: 10.1016/j.aca.2023.341934

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Development of lycopene-based whole-cell biosensors for the visual detection of trace explosives and heavy metals

Meijie Li,

Shuzhe Lv,

Rumeng Yang

et al.

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2024

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Cited by 58 publications

References 38 publications

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2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

Nisar,

Dastgeer,

Shazad

et al. 2024

Advanced Science

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Since two‐dimensionalal (2D) materials have distinct chemical and physical properties, they are widely used in various sectors of modern technologies. In the domain of diagnostic biodevices, particularly for point‐of‐care (PoC) biomedical diagnostics, 2D‐based field‐effect transistor biosensors (bio‐FETs) demonstrate substantial potential. Here, in this review article, the operational mechanisms and detection capabilities of biosensing devices utilizing graphene, transition metal dichalcogenides (TMDCs), black phosphorus, and other 2D materials are addressed in detail. The incorporation of these materials into FET‐based biosensors offers significant advantages, including low detection limits (LOD), real‐time monitoring, label‐free diagnosis, and exceptional selectivity. The review also highlights the diverse applications of these biosensors, ranging from conventional to wearable devices, underscoring the versatility of 2D material‐based FET devices. Additionally, the review provides a comprehensive assessment of the limitations and challenges faced by these devices, along with insights into future prospects and advancements. Notably, a detailed comparison of FET‐based biosensors is tabulated along with various other biosensing platforms and their working mechanisms. Ultimately, this review aims to stimulate further research and innovation in this field while educating the scientific community about the latest advancements in 2D materials‐based biosensors.

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2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

Nisar,

Dastgeer,

Shazad

et al. 2024

Advanced Science

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Sequential Detection of Hg²⁺ and TNT Using a Nitrogen‐Doped Polymeric Carbon Dots On–Off–On Fluorescence Sensor

Radhakrishnan,

Suriyaprakash,

Shunmugakani

et al. 2024

Polymers for Advanced Techs

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This work presents a fluorescence sensor based on nitrogen‐doped carbon dots (N‐CDs) utilized for sequential detection of Hg2+ and TNT. The N‐CDs were produced by a simple and efficient hydrothermal process involving the combination of black bean extract with citric acid (CA) and ethylenediamine (EDA). The resulting N‐CDs exhibit a steady blue fluorescence with a significant quantum yield of 12%. We conducted a thorough investigation into the mechanism by which the fluorescence of NCDs is reduced in the presence of Hg2+. Our analyses, which included Stern–Volmer quenching tests, confirmed the development of a stable complex between N‐CDs and Hg2+. When the NCDs‐Hg2+ complex was exposed to TNT, the fluorescence was selectively restored. This sequential “on–off–on” sensing capacity allows for efficient monitoring of both Hg2+ and TNT, demonstrating good sensitivity and selectivity. The sensor has a low detection limit (LOD) of 3.1 and 46 nM for Hg2+ ions and TNT in a linear range of 0–40 and 0–30 μM, respectively. This study emphasizes the potential application of N‐CDs for detecting heavy metals and explosives at the same time. It highlights their usefulness in sophisticated environmental sensing technologies that are suitable for important applications.

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An Ultrasensitive Electrochemical DNA‐Nano Biosensor for Monitoring Tirapazamine as Anticancer Drug Using Zno/Co₃O₄ Nanocomposite

Alkhathami,

Ali,

Abdalhuseen

et al. 2024

ChemistrySelect

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In this study, we used a screen‐printed electrode (SPE) modified with polypyrrole (PP), ZnO/Co3O4 nanocomposite, and ds‐DNA as an extremely sensitive DNA biosensor to monitor tirapazamine (TPZ) real samples. To build the ds‐DNA/PP/ZnO/Co3O4 NC/SPE biosensor, the layer‐by‐layer manufacturing process was used. The proper alteration of the SPE surface as well as the effective fabrication of the ZnO/Co3O4 nanocomposite were both validated by the physicochemical characterization techniques. As a result of improving its conductivity of electricity along with allowing charged particles to move more easily, the modified SPE demonstrated much decreased the resistance of charge transfer based on the results of electrochemical impedance spectroscopy. With the 0.43 nM LOD value, the suggested biosensor effectively measured TPZ throughout a broad concentration between 0.001 and 120 µM. Additionally, the molecular docking investigation among the TPZ molecule as well as the DNA was conducted to anticipate the TPZ contact sites with DNA and verified the experimental results. By combining the benefits of ZnO/Co3O4 nanocomposite with vital information from the molecular docking investigation, the current research lays the door for the creation of very sensitive DNA biosensors, which can be utilized to track and measure TPZ of real samples.

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Development of lycopene-based whole-cell biosensors for the visual detection of trace explosives and heavy metals

Cited by 58 publications

References 38 publications

2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

Sequential Detection of Hg²⁺ and TNT Using a Nitrogen‐Doped Polymeric Carbon Dots On–Off–On Fluorescence Sensor

An Ultrasensitive Electrochemical DNA‐Nano Biosensor for Monitoring Tirapazamine as Anticancer Drug Using Zno/Co₃O₄ Nanocomposite

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Development of lycopene-based whole-cell biosensors for the visual detection of trace explosives and heavy metals

Cited by 58 publications

References 38 publications

2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

Sequential Detection of Hg2+ and TNT Using a Nitrogen‐Doped Polymeric Carbon Dots On–Off–On Fluorescence Sensor

An Ultrasensitive Electrochemical DNA‐Nano Biosensor for Monitoring Tirapazamine as Anticancer Drug Using Zno/Co3O4 Nanocomposite

Contact Info

Product

Resources

About

Sequential Detection of Hg²⁺ and TNT Using a Nitrogen‐Doped Polymeric Carbon Dots On–Off–On Fluorescence Sensor

An Ultrasensitive Electrochemical DNA‐Nano Biosensor for Monitoring Tirapazamine as Anticancer Drug Using Zno/Co₃O₄ Nanocomposite