In this paper, a solution to the problem of analyzing the life cycle of machine parts with cracks under harmonic loading in the domain of high-cycle fatigue is proposed. Such an external influence, besides an independent contribution, can be effectively used as a base for stochastic loading. Stochastic loading is usually understood as any possible type of external loading, including random loading. Universal solutions for analysis of the durability of machine parts with cracks under harmonic loading are proposed. Specialized industrial software for performing fatigue calculation procedures is developed. The software verification procedure that can be used to evaluate the reliability of the results is presented. The proposed solutions are based on the strength analysis using the finite element method and implemented in the APM Structure3D software.