Development of melamine certified reference material in milk using two different isotope dilution mass spectrometry techniques

Hon, Phoebe Y.T.; Chu, Patricia W.S.; Cheng, Chi-ho; Lee, Terry C.L.; Chan, Pui-kwan; Cheung, Samuel T.C.; Wong, Yiu‐chung

doi:10.1016/j.chroma.2011.08.021

Cited by 25 publications

(16 citation statements)

References 21 publications

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“…The diagnosis of melamine poisoning is based on the presence of melamine and cyanuric acid in urine or kidney samples from affected animals or contaminated food or feed. Gas chromatography/mass spectroscopy (MS) and liquid chromatography/tandem MS are used to analyze melamine and cyanuric acid (Cianciolo et al, 2008;Hon et al, 2011;Puschner and Reimschuessel, 2011). Several methods are available for the detection and quantification of melamine and its related analogs (Chang et al, 2012;Unger et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

2014

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This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of honey treatment. In conclusion, this study revealed that natural bee honey protects the kidney against the adverse effects induced by melamine toxicity in male albino rats.

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Section: Introductionmentioning

confidence: 99%

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

2014

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“…Expanded uncertainty of the IDMS measurements was estimated from individual uncertainty components listed in formula (1) based on the Guide to the Expression of Uncertainty in Measurement . The uncertainty associated with the ID GC–MS/MS analysis was contributed by balance weighing ( u rel,w ; including weighing of sample, standard solutions of the natural and labeled isotope), purity of reference materials ( u rel,p ), and the method imprecision that was the RSD of the determinations ( u rel,rep ) .…”

Section: Resultsmentioning

confidence: 99%

Determination of phthalate esters in Chinese spirits using isotope dilution gas chromatography with tandem mass spectrometry

Wang

Zhang

et al. 2015

J of Separation Science

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Phthalate esters are additives used in polyvinylchloride and are found as contaminants in many food products. An isotope dilution mass spectrometry technique has been developed for accurate analysis of 16 phthalate esters in Chinese spirits by adopting the 16 corresponding isotope-labeled phthalate esters. The ethanol in the spirit sample was first removed by heating with a water bath at 100°C with a stream of nitrogen, after which the residue was extracted with n-hexane twice. The phthalates collected were identified and quantified by gas chromatography with tandem mass spectrometry in multiple reaction monitoring mode. The spiking recoveries of 16 analytes ranged from 94.3 to 105.3% with relative standard deviation values of <6.5%. The detection limits for 16 analytes were <10.0 ng/g. The expanded relative uncertainties were from 3.0 to 14%. A survey was performed on Chinese spirits from the market. Six of the nine analyzed samples were contaminated by phthalates. Di-n-butyl phthalate and di-2-ethylhexyl phthalate showed higher detection frequency and concentrations. This isotope dilution gas chromatography with tandem mass spectrometry method is simple, rapid, accurate, and highly sensitive, which qualifies as a candidate reference method for the determination of phthalates in spirits.

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“…The molecular ion of urea (m/z ¼ 60) was not detected in any case. The presence of m/z ¼ 43 ion (considered to be isocyanic acid), m/z ¼ 27 (hydrogen cyanide) and m/z ¼ 17 (ammonia) during decomposition of GO 300 sample revealed a large variety of nitrogen surface groups in this material, [34][35][36] which in part could be assigned to strongly adsorbed quasiurea species. The simultaneous detection of m/z ¼ 44 signal (carbon dioxide) and m/z ¼ 17 (ammonia) could be consequence of a reaction among the isocyanic acid evolved and residual water molecules.…”

Section: Characterization Of Carbon Materialsmentioning

confidence: 97%

Selective 1,3-butadiene hydrogenation by gold nanoparticles deposited & precipitated onto nano-carbon materials

Castillejos¹,

Bachiller‐Baeza

Asedegbega–Nieto³

et al. 2015

RSC Adv.

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Development of melamine certified reference material in milk using two different isotope dilution mass spectrometry techniques

Cited by 25 publications

References 21 publications

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

Determination of phthalate esters in Chinese spirits using isotope dilution gas chromatography with tandem mass spectrometry

Selective 1,3-butadiene hydrogenation by gold nanoparticles deposited & precipitated onto nano-carbon materials

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