Development of mental health dysfunction in childhood epilepsy

Noeker, Meinolf; Haverkamp-Krois, Andrea; Haverkamp, F.

doi:10.1016/j.braindev.2004.02.008

Cited by 57 publications

(37 citation statements)

References 83 publications

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“…The following causes or conditions for the development of psychopathology are assumed: direct symptomatic effect of the underlying CNS pathology and of seizure activity, side effects of AEDs, secondary effect of neurocognitive impairment, cumulative coping failure with epilepsy-associated stressors, contextual environmental risk factors, and additional biological and psychosocial vulnerabilities [31].…”

Section: Discussionmentioning

confidence: 99%

Mental health problems in children and adolescents referred to a national epilepsy center

Hanssen‐Bauer

Heyerdahl

Eriksson³

2007

Epilepsy & Behavior

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This study aimed to investigate the occurrence of psychiatric morbidity in children and adolescents referred to a tertiary national epilepsy center (inpatient unit) and the extent of the unmet need for psychiatric services in this group. Participants were 74 children and adolescents aged 9-15 years referred from February 2001 to October 2002 (67% response rate). The multi-informant (parent, teacher, self-report) Strengths and Difficulties Questionnaires (SDQ) were answered before or at admission. Patients with severe mental retardation or pervasive developmental disorder were excluded. We found a high proportion (77%) with a possible or probable psychiatric disorder. The parents, teachers, and the adolescents themselves had higher mean SDQ scores than a British community sample on total difficulties, emotional symptoms, conduct problems, hyperactivity-inattention, peer problems, and impairment, except self-reported conduct problems. Nearly 80% of the children who probably had a psychiatric disorder had no contact with the psychiatric service.

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Section: Discussionmentioning

confidence: 99%

Mental health problems in children and adolescents referred to a national epilepsy center

Hanssen‐Bauer

Heyerdahl

Eriksson³

2007

Epilepsy & Behavior

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“…It could be reasoned that individuals who have frequent seizures have a harder time adapting to and participating in social groups and feel rejected (26), which may lead to higher depression scores. Moreover, more frequent seizures may have caused a higher degree of organic damage and a tendency to depressive temperament due to social interaction in our participants.…”

Section: Association Of Clinical Findings and Personality Traits Of Ementioning

confidence: 99%

Affective Temperaments in Epilepsy

Yazıcı¹,

Yazıcı²,

Varoğlu³

et al. 2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…3,4 While increased rates of DSM-IV disorders have been reported in some investigations of adults with chronic medication resistant temporal lobe epilepsy, 4 controlled pediatric studies have failed to find differences between localization-related versus generalized epilepsies. 5,6 This was the case here, with some qualification.…”

Section: Risk Of Dsm-iv Psychiatric Disorders In New Onset Localizatimentioning

confidence: 99%

“…These core findings have been replicated and refined in a large number of clinical investigations using self-report and proxy-based measures of emotional-behavioral status. 3 In contrast to the literature on adult epilepsy, where mental health problems have been characterized systematically using standardized interview protocols (e.g. the Structured Clinical Interview for DSM-IV-TR) and contemporary psychiatric nomenclature as outlined in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) and the World Health Organization Classification of Mental and Behavioural Disorders, 4 similar efforts in the pediatric epilepsy literature have just begun.…”

mentioning

confidence: 99%

Psychiatric comorbidity in children with new onset epilepsy

Jones

Watson

Sheth

et al. 2007

Develop Med Child Neuro

250

168

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The aim of this study was to characterize the distribution, timing, and risk factors for psychiatric comorbidity in children with recent onset epilepsy. Children aged 8 to 18 years with recent onset epilepsy (<1 year in duration) of idiopathic etiology (n=53) and a healthy comparison group (n=50) underwent a structured psychiatric diagnostic interview to characterize the spectrum of lifetime-to-date history of comorbid psychiatric disorder. There was no significant difference between the children with recent onset epilepsy and healthy comparison children in sex (31 males, 22 females vs 23 males, 27 females) or mean age 12.7y [SD 3.3] vs 12.7y [SD 3.2]). Children with recent onset epilepsy exhibited an elevated rate of lifetime-to-date Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) Axis I disorders compared with the comparison group. They showed significantly higher rates of depressive disorders (22.6 vs. 4%, p=0.01), anxiety disorders (35.8 vs 22%, p<0.05), and attention-deficit-hyperactivity disorder (26.4 vs 10%, p=0.01) with elevated but less prevalent rates of oppositional defiant and tic disorders. A subset of children with epilepsy (45%) exhibited DSM-IV Axis I disorders before the first recognized seizure, suggesting the potential influence of antecedent neurobiological factors that remain to be identified. The increased prevalence of psychiatric comorbidity antedating epilepsy onset may be consistent with the presence of underlying neurobiological influences independent of seizures, epilepsy syndrome, and medication treatment.Two population-based epidemiological investigations, conducted in the UK decades apart, demonstrate that psychiatric comorbidity is a significant complication of chronic childhood epilepsy. In the well-known Isle of Wight study, Rutter et al. 1 reported that 7% of children in the general population exhibited a mental health problem compared with 12% of children with non-neurological physical disorders. Significantly, higher rates were reported in epilepsy: 29% in children with uncomplicated and 58% in those with complicated epilepsy (i.e. structural brain abnormalities and seizures). In the recent UK epidemiological investigation conducted by Davies et al., 2 some 30 years after the Rutter et al. study, strikingly similar findings were reported. Psychiatric disorders were found in 9.3% of the general population aged 5 to 15 years, in 10.6% of those with a chronic medical disorder (diabetes), again with increased rates in epilepsy, including 26% in uncomplicated epilepsy and 56% in complicated epilepsy. These epidemiological studies confirm that children and adolescents with chronic epilepsy are at increased risk of mental health problems compared with the general population and children with other chronic non-neurological conditions. These core findings have been replicated and refined in a large number of clinical investigations using self-report and proxy-based measures of emotional-behavioral status. 3

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Development of mental health dysfunction in childhood epilepsy

Cited by 57 publications

References 83 publications

Mental health problems in children and adolescents referred to a national epilepsy center

Mental health problems in children and adolescents referred to a national epilepsy center

Affective Temperaments in Epilepsy

Psychiatric comorbidity in children with new onset epilepsy

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