Development of Mesoporous Silica Nanomaterials As a Vehicle for Anticancer Drug Delivery

Abstract

The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a solid framework with porous structure and high surface area that allows for the attachment of different functional groups. In this article we discuss the different surface modifications made to MSNs that have allowed for the construction of targeted nanoparticles to enhance accumulation and uptake in target sites, the incorporation of nanomachines for controlled cargo release and the combination with superparamagnetic metals for MRI cell labeling. We also discuss biocompatibility, biodistribution and drug-delivery efficacy of MSNs. Finally, we mention the construction of multifunctional nanoparticles that combine all of the previously examined nanoparticle modifications.

Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden

“…Further studies are warranted to build upon previous studies that examine the timing and biodistribution of the MSNs. 59, 60 …”

Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

“…Many nanomaterials have been engineered that promise to enhance drug delivery efficacy to target tissues, reduce side effects, and provide a delivery vehicle for hydrophobic anticancer drugs or imaging agents. Among these materials, MCM‐41 mesoporous silica has received much attention because of its large surface area, large internal pore volume, tunable pore size and good chemical and thermal stability 1–6. Mesoporous silica nanoparticles (MSNs) are taken up into cancer cells by energy‐dependent endocytosis and the majority of them co‐localize with the endo/lysosomal compartments 7–11.…”

Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

“…In fact, magnetic nanoparticles with a size range of 10-100 nm have been used as an external magnetic responsive multimodal DDS due to their superparamagnetic properties [46]. In fact, magnetic nanoparticles with a size range of 10-100 nm have been used as an external magnetic responsive multimodal DDS due to their superparamagnetic properties [46].…”