Development of metallosupramolecular phosphatases based on the combinatorial self-assembly of metal complexes and organic building blocks for the catalytic hydrolysis of phosphate monoesters

Aoki, Shin; Rahman, Akib Bin; Hisamatsu, Yosuke; Miyazawa, Yuya; Zulkefeli, Mohd; Saga, Yoshitaka; Tanaka, Tomohiro

doi:10.1016/j.rechem.2021.100133

Cited by 3 publications

(3 citation statements)

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“…3 (A) depicts the most commonly used phosphoester models. The representative phosphomonoester mimic 4-nitrophenyl phosphate (NPP) [67] , [84] , [85] and phosphodiester mimics bis(4-nitrophenyl) phosphate (BNPP) [60] , [69] , [74] , [79] and bis-(2,4-dinitrophenyl) phosphate (BDNPP) [57] , [78] , [75] , [76] are used for mimicking the nature of various phosphoester bonds. While all the above play a typical deoxynucleotide role, 2-hydroxypropyl 4-nitrophenyl phosphate (HPNPP) has a hydroxyl group on the side chain displaying an RNA analogue.…”

Section: Models Substrates and Instrumentations Employedmentioning

confidence: 99%

“…iii) Modification of the second coordination sphere via addition of the functional groups or by using the supramolecular hosts such as cyclodextrins (CDs) [56] , [57] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] . iv) Development of supramolecular systems by the self-assembly of metal complexes and organic building units [84] , [85] , [86] , [87] , [88] . v) Construction of metallomicell catalysts from the self-assembly of amphiphilic metal complexes [89] , [90] , [91] .…”

Section: Introductionmentioning

confidence: 99%

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Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

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Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.

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Section: Models Substrates and Instrumentations Employedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

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“…It is well established that macrocyclic polyamine ligands such as 1,4,7-triazacyclononane ( [9]aneN 3 ) 1, 1,4,7,10-tetraazacyclododecane ( [12]aneN 4 , cyclen) 2, and 1,4,7,10,13-pentaazacyclopentadecane ([15]aneN 5 ) 3 are able to form more stable complexes 4-6 with metal ions such as Cu 2+ , Ni 2+ , and Zn 2+ in aqueous solution (Figure 1) than metal complexes of linear polyamine types [16,17]. In addition, metal ions in these complexes, especially the Zn 2+ ion in Zn 2+ -cyclen complex (5), possess strong Lewis acidity and the deprotonated Zn 2+ -bound H 2 O (HO − ) functions as a nucleophile and a base in aqueous solution at neutral pH [18][19][20][21][22][23].…”

Section: Development Of D-block Metal Ions Probes Based On the Cleava...mentioning

confidence: 99%

Design, Synthesis, and Biological Applications of Boron-Containing Polyamine and Sugar Derivatives

Aoki¹,

Ueda²,

Tanaka³

et al. 2022

Characteristics and Applications of Boron

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Boron (B), an element that is present in ultratrace amounts in animal cells and tissues, is expected to be useful in many scientific fields. We have found the hydrolysis of C–B bond in phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane) and the full decomposition of ortho-carborane attached with cyclen and ethylenediamines in aqueous solution at neutral pH upon complexation with intracellular metals. The change in the chemical shift of the 11B signals in 11B-NMR spectra of these boron-containing metal chelators can be applied to the magnetic resonance imaging (MRI) of metal ions in solutions and in living cells.

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Comparative DNA binding ability and phosphatase-like activity of mono and dinuclear Ni (II) complexes: a structure-activity correlation

Yadav,

Kumar,

Rishu

et al. 2024

J Chem Sci

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Development of metallosupramolecular phosphatases based on the combinatorial self-assembly of metal complexes and organic building blocks for the catalytic hydrolysis of phosphate monoesters

Cited by 3 publications

References 118 publications

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Design, Synthesis, and Biological Applications of Boron-Containing Polyamine and Sugar Derivatives

Comparative DNA binding ability and phosphatase-like activity of mono and dinuclear Ni (II) complexes: a structure-activity correlation

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