2019
DOI: 10.1208/s12249-019-1581-y
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Development of Methotrexate and Minocycline-Loaded Nanoparticles for the Effective Treatment of Rheumatoid Arthritis

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Cited by 16 publications
(9 citation statements)
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“…Therefore, ESR, WBCs values were significantly decreased in arthritic rats after therapeutic use of nanoparticles. Our results were comparable to those of other previous studies as well (Janakiraman et al, 2020).…”
Section: Discussionsupporting
confidence: 93%
“…Therefore, ESR, WBCs values were significantly decreased in arthritic rats after therapeutic use of nanoparticles. Our results were comparable to those of other previous studies as well (Janakiraman et al, 2020).…”
Section: Discussionsupporting
confidence: 93%
“…The blank TDs did not exhibit significant cytotoxicity in the MDA-MB-231 cell culture at 1 mg/mL (Figure 5C). Consistent with the literature, 49 the dose-dependent cytotoxicity of MTX was observed in Raw 264.7 cell incubation with an IC 50 of 12 ng/mL. In contrast, the breast cancer cell line MDA-MB-231 is not sensitive to MTX due to the low expression level of reduced folate carrier, a transmembrane transporter for MTX cell uptake.…”
Section: Mtx Loading Efficiency and Stabilitysupporting
confidence: 89%
“…Methotrexate and minocycline-loaded nanoparticles were developed to relieve inflammation and disease progression/joints stiffness and control the bacterial infections associated with rheumatoid arthritis. 22 The pathogenesis of inflammatory skin diseases is complex and diverse. Whether the pathogenesis of GD may be related to immunity still needs a lot of data support and more in-depth research.…”
Section: Discussionmentioning
confidence: 99%