Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis

Abstract

Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana , which is one of the most common insects in the nature, can be extracted to treat UC. However, the active components in Periplaneta americana extract (PAE) can be degraded in the stomach due to its extreme acidic environment and enzyme. In this study, we developed a pH-dependent drug delivery method using polymer cellulose acetate (Eudragit S100) as a carrier to deliver high concentration PAE to inflamed colon. Both in vitro and in vivo results showed the PAE-Eudragit-S100 could treat UC through delivering active drug components to colon without degradation.

Phytochemical Profiling, Isolation, and Pharmacological Applications of Bioactive Compounds from Insects of the Family Blattidae Together with Related Drug Development

“…In general, their bioactive constituents exhibit stronger pharmacological effects than those of plants. As the famous representative, the insects of the family Blattidae have a long history of medicinal application, and some studies have demonstrated their antitumor [1][2][3], tissue repair [4][5][6], antibacterial [7], antiviral [8], and other pharmacological effects [9,10]. The family Blattidae belongs to Arthropoda, Insecta, Pterygota, Blattariae in entomological taxonomy, which has existed on the earth for 320 million years [11].…”