Cross-section profile of rotor takes a great effect on the performance of dry-screw vacuum pump. A novel smooth rotor profile consisting of eight segments of curves, including arcs and conjugate correction curves is proposed. Advantages are that it can be used to solve the unsmooth connection and no meshing clearance in traditional profile. The meshing model for new profile can directly generate stable addendum clearance, tooth clearance, tooth side clearance, and radial clearance. The influences of the epicycloid rotation angle, arc radius and involute offset distance of the conjugate correction curve on the clearances are studied according to established theoretical model. And transient flow field of vacuum pump is analyzed by using the commercial software Ansys-Fluent®. Compared to traditional screw vacuum pump, the results shows that pressure in inlet and pump cavity is lower, and maximum pumping speed is higher, indicating that the proposed design is superior.