Development of Models for the Estimation of Mouth Level Exposure to Aerosol Constituents from a Heat-Not-Burn Tobacco Product Using Mouthpiece Analysis

Poget, Laurent; Campelos, Pedro; Jeannet, Cyril; Maeder, Serge

doi:10.1515/cttr-2017-0005

Cited by 8 publications

(4 citation statements)

References 15 publications

(16 reference statements)

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“…The user's mouth level exposure (MLE) was estimated from the amount of nicotine analyzed in mouthpiece filters recovered from the used THS 2.2 HeatSticks during the study (Supplementary Table S9). The mouthpiece filter analysis for the estimation of a HeatStick user's MLE is a method proposed in a published study (Poget et al 2017). This determination requires pre-defined linear calibration regression equations calculated between nicotine yields in mainstream aerosols and corresponding nicotine amounts in mouthpiece filters.…”

Section: Results Obtained For Measurements Of Nicotine In Filtersmentioning

confidence: 99%

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

Mitova

Bielik

Campelos

et al. 2019

Air Qual Atmos Health

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Despite the growing popularity of new alternatives to traditional tobacco products, there is still limited evidence on their indoor effect in particular in residential spaces as specific environments where enforcement of air quality standards is difficult. Hence, the impact of the Tobacco Heating System 2.2 (THS, marketed as IQOS®) on indoor air quality was assessed under controlled experimental conditions using ventilation representative of residential buildings with natural ventilation. Smoking of cigarettes (Marlboro Gold®) at the same ventilation conditions and consumption rates was used as positive control. Before each THS 2.2 or Marlboro Gold session, a background session with the same volunteers as for the product-use session was held. In the high-load simulated residential environment, out of the 24 measured airborne constituents, only the increase of the indoor concentrations of nicotine, acetaldehyde, and glycerin above the background was attributable to the use of THS 2.2. The quantified concentrations of these three airborne compounds were significantly below the harmful levels defined in the air quality guidelines. Smoking Marlboro Gold resulted in much greater increases in the concentrations of all measured indoor air constituents, except for glycerin, and the indoor concentrations of several constituents exceeded the exposure levels set forth by cognizant authorities. Based on these data, it is reasonable to conclude that the use of THS 2.2 in environments where norms for indoor exposure in terms of adequate ventilation are respected does not adversely affect the overall indoor air quality.

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Section: Results Obtained For Measurements Of Nicotine In Filtersmentioning

confidence: 99%

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

Mitova

Bielik

Campelos

et al. 2019

Air Qual Atmos Health

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“…[7] [8] for a general discussion of ENDS; [9] [10] for comparative studies of the effect of ENDS on active and passive smokers; or [11] [12] for general literature reviews; and 2) tobacco heated systems (THS), also addressed as heat-not-burn tobacco products (HNB)-see e.g. [13] [14] for a general discussion of THS2.2 devices; [15] [16] for studies comparing the emission from THSs with that of ordinary cigarettes; or [17] [18] for modelling of aerosol formation in THSs and their analysis. Note that one of the THSs is commercially known as iQOS, which is the THS used in the present investigation.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Non-Volatile Compounds Present in 3R4F Cigarettes and iQOS Heatsticks Utilizing GC-MS

Ibáñez¹,

Martín²,

Gonzálvez³

et al. 2019

AJAC

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It is now widely suggested that people who are dependent on nicotine should switch from ordinary tobacco smoking to alternative products, which at least reduce the overall harm from smoking. A number of alternatives are now popular, including electronic cigarettes and heatsticks. In this work comparative analysis of the smoke/aerosol emission from 3R4F standard cigarettes and iQOS heatsticks was undertaken. For this, gas chromatography-mass spectrometry (GC-MS) analysis was applied, to measure the non-volatile compounds of smoke/aerosol emission from individual samples, with the specific aim to determine their content of nicotine and selected other main components. All measurement data were collected under the Health Canada Intense (HCI) puffing regime. The most relevant findings of the present investigation can be summarized as follows. First, the number of measured aerosol components in the iQOS samples, with respect to those of 3R4F samples, was significantly lower (notably 37 versus 12 components). Second, the analysis of the iQOS and 3R4F GC-MS chromatographic fingerprints indicated a non-nicotine global component reduction (number and areas excluding nicotine) of larger than 80% for the iQOS samples in comparison to 3R4F samples. Third, the nicotine content of the iQOS aerosol was less than half that contained in the 3R4F smoke. The results from the present investigation indicate that-except for nicotine-smokers are exposed to a largely reduced number and amount of non-volatile, non-nicotine components in the iQOS heatstick aerosol, in comparison to those in the 3R4F cigarette smoke.

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“…Comparative data between heated tobacco products and conventional cigarettes is either based on direct quantitative results for both product groups reported within the same article, quantitative data reported elsewhere within the scientific literature for the conventional cigarette comparison, or a combination of both. Other approaches quantified HPHCs within aerosols experimentally produced from heated tobacco products without discussion of conventional cigarettes; in such cases, data can be extracted where the HPHC was determined to be below either the limit of detection or limit of quantification of the analytical method employed (Poget et al, 2017).…”

Section: Harmful and Potentially Harmful Constituents (Hphcs)mentioning

confidence: 99%

The product science of electrically heated tobacco products: a narrative review of the scientific literature

Malt

Thompson²,

Mason

et al. 2022

F1000Res

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Heated tobacco products represent a novel category of tobacco products in which a tobacco consumable is heated to a temperature that releases nicotine from the tobacco leaf but not to a temperature sufficient to cause combustion. Heated tobacco products may therefore have the potential to be a less harmful alternative for adult smokers that would otherwise continue to smoke conventional cigarettes. Given the rapid development of this product category, the aim of this review was to examine the available peer-reviewed scientific evidence related to heated tobacco products and highlight any research gaps. In recent years, manufacturers of heated tobacco products have published a number of studies on their respective heated tobacco products. Whilst there is limited research that is independent of commercial interests, the available scientific evidence indicates that heated tobacco products produce a much simpler aerosol than conventional cigarette smoke, with fewer and substantially lower levels of harmful toxicants. Toxicology assessments indicate these reductions in aerosol toxicants translate to reduced biological effects. Biomarker and clinical data from studies in which product use is controlled within a clinical setting, indicate changes in biomarker levels and clinical end-points similar to observations in cessation studies, indicating the potential for reduced harm. The scientific evidence also indicates that exposure of non-users to emissions from heated tobacco products in indoor environments is significantly reduced compared to exposure resulting from smoking conventional cigarettes. Overall, the available scientific evidence indicates that heated tobacco products hold promise as a less harmful alternative to conventional cigarettes, but more independent data is required to validate industry findings. As a growing product category, epidemiological studies and independent population modelling studies are outstanding, and empirical data on how dual tobacco product category use by consumers affects their risk profile is lacking.

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Development of Models for the Estimation of Mouth Level Exposure to Aerosol Constituents from a Heat-Not-Burn Tobacco Product Using Mouthpiece Analysis

Cited by 8 publications

References 15 publications

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

A Comparative Study of Non-Volatile Compounds Present in 3R4F Cigarettes and iQOS Heatsticks Utilizing GC-MS

The product science of electrically heated tobacco products: a narrative review of the scientific literature

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