Development of mucoadhesive patches for buccal administration of ibuprofen

Perioli, Luana; Ambrogi, Valeria; Angelici, Fausta; Ricci, Maurizio; Giovagnoli, Stefano; Capuccella, Marinella; Róssi, Carlo

doi:10.1016/j.jconrel.2004.06.005

Cited by 216 publications

(144 citation statements)

References 13 publications

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“…The surface pH was measured by means of pH paper placed on the surface of the swollen patch. Swelling Studies (12) After weighing the patch (W 1 ), it was immersed in pH 6.8 phosphate buffer solution maintained at 37°C. The weight at end of 120 min was reported (W 2 ).…”

Section: Content Uniformitymentioning

confidence: 99%

Mucoadhesive Bilayered Patches for Administration of Sumatriptan Succinate

et al. 2008

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Abstract. The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. The patches were prepared by the solvent casting method. Gelatin and polyvinyl pyrrolidone (PVP) K30 were incorporated into the patches, to improve the film properties of the patches. The patches were found to be smooth in appearance, uniform in thickness, weight, and drug content; showed good mucoadhesive strength; and good folding endurance. A 3 2 full factorial design was employed to study the effect of independent variables viz. levels of chitosan and PVP K30, which significantly influenced characteristics like swelling index, in-vitro mucoadhesive strength, in vitro drug release, and in-vitro residence time. Different penetration enhancers were tried to improve the permeation of sumatriptan succinate through buccal mucosa. Formulation containing 3% dimethyl sulfoxide showed good permeation of sumatriptan succinate through mucosa. Histopathological studies revealed no buccal mucosal damage. It can be concluded that buccal route can be one of the alternatives available for administration of sumatriptan succinate.

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Section: Content Uniformitymentioning

confidence: 99%

Mucoadhesive Bilayered Patches for Administration of Sumatriptan Succinate

et al. 2008

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“…Although researchers have introduced a variety of products, their local application has not been long lasting. Therefore, we modified a mucous-adhesive method for the relief of discomfort and fear of injection by designing a fast-release formula 17,18) . The bi-layered structure was designed to avoid the strip being washed out by saliva and to deliver drug unidirectionally to the mucosa.…”

Section: Discussionmentioning

confidence: 99%

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

et al. 2016

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To overcome pain on injection, the dentist can apply a topical anesthetic spray. Despite the convenience, it is not easy to apply it locally. So, we developed an oral mucoadhesive bi-layer film containing an anesthetic. We used polyvinylpyrrolidone (PVP)/ hydroxypropyl methylcellulose (HPMC) and HPMC-only layer as the drug-containing layer and ethyl cellulose (EC) as the backing layer. The lidocaine released was tested in vitro together with the adhesion time and cytotoxicity of the film. Mucosa permeability was tested in vivo. Statistical analysis was performed, with p at 0.05 taken to be significant. The lidocaine was released significantly faster in the PVP/HPMC than HPMC-only group and 80% of the drug was released within 1 min (p<0.05) and they attached at least 3 h. The test groups showed no toxicity and the drug effectively permeated the mucosa (p<0.05). We suggest this new mucoadhesive anesthetic may reduce dental phobia.

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“…According to these results, there were no statistically significant differences between the thickness of the film in all cases (94.44 ± 4.81 mm SCMC, 92.78 ± 0.96 mm HPMC and 92.22 ± 2.55 mm chitosan p40.05). In all cases thickness was suitable for application in the oral cavity (Perioli et al, 2004). The drug content per gram of transbuccal systems was 1.18 ± 0.06 mg, 2.80 ± 0.17 mg and 3.05 ± 0.20 mg for SCMC, HPMC and chitosan, respectively.…”

Section: Films Characterizationmentioning

confidence: 93%

“…The study was performed in triplicate for each type of transbuccal patch (Nafee et al, 2003;Perioli et al, 2004;Don et al, 2008;Derle et al, 2009). …”

Section: Swelling Studiesmentioning

confidence: 99%

“…Mucoadhesive drug delivery systems, including matrix tablets, films, layered systems, discs, microspheres, ointments and hydrogel systems, have been studied and reported by several research groups (Martín del Valle et al, 2009;Satheesh et al, 2009;Giovino et al, 2012;Kianfar et al, 2012;Boateng et al, 2013;Kianfar et al, 2013;Meher et al, 2013). Buccal films are preferable over any other system in terms of flexibility and comfort (Perioli et al, 2004). They also offer advantages over creams and ointments since they provide a measured dose of drug to the application site, thus reducing pain and increasing treatment effectiveness .…”

Section: Introductionmentioning

confidence: 99%

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Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

et al. 2014

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may have analgesic local effect due to its biochemical mechanism of action. Delivery of DH directly to the oral cavity could be an interesting alternative for toothache due to its analgesic local effect. One problem associated with the mucosal administration routes is the short residence time of the dosage form on the mucosal membranes. In this sense, we have developed new doxepin mucoadhesive films able of reducing pain and increasing the effectiveness of treatment. For this purpose, we tested three different polymers: chitosan, sodium hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (SCMC) in film elaboration. The results obtained show that all films are hydrophilic matrices that absorb water when placed in an aqueous media. All the films hydrated very quickly, reaching high percentage of swelling after just few minutes (5 min for SCMC, 2 min for HPMC and 30 min for chitosan). Moreover, the SCMC and HPMC films were dissolved whereas chitosan was not dissolved. Dissolution also leads to viscous liquids with a higher retention time over mucosal surfaces what may lead to adhesive interactions. In vitro permeation studies showed that for all the formulations studied, SCMC (19.91%), HPMC (69.5%) and chitosan (24.17%), the percentage of drug permeated increased compared to the drug solution (8.26%). Specifically the HPMC film presents greater amounts of doxepin permeated (49.27 ± 4.47 mg/cm 2 ).

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Development of mucoadhesive patches for buccal administration of ibuprofen

Cited by 216 publications

References 13 publications

Mucoadhesive Bilayered Patches for Administration of Sumatriptan Succinate

Mucoadhesive Bilayered Patches for Administration of Sumatriptan Succinate

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

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