Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

Anitha, A; Deepa, N.; Chennazhi, K.P.; Nair, Shantikumar V.; Tamura, Hiroshi; Jayakumar, R.

doi:10.1016/j.carbpol.2010.07.028

Cited by 166 publications

(96 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Encapsulation can also isolate a substance from the surrounding matter reactions (Matsuno & Adachi, 1993). Chitosan is an ideal polymeric shell component of oily nanocapsules because it has advantageous biological properties, such as biocompatibility (Khalid et al, 2006), biodegradability (Okamoto et al, 2002;Aguirre-Loredo et al, 2017), antimicrobial activity (Li et al, 2008), mucoadhesivity (Anitha et al, 2011), low toxicity (Chaparro-Hernández et al, 2015) and permeability enhancement (Tobío et al, 2000). Sodium tripolyphosphate is an anionic cross-linker; it exhibits non-toxicity and quick gelling ability that make it a favorable cross-linker for ionic gelation of chitosan (Kafshgari et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Xiao

Zhu

2017

Food Sci. Technol

View full text Add to dashboard Cite

Linalool has been extensively applied in various fields, such as flavoring agent, perfumes, cosmetics and medical science. However, linalool is unstable, volatile and readily oxidizable. A sensitive substance can be encapsulated in a capsule, so encapsulation technology can solve these problems. In this paper, linalool-loaded nanocapsules (Lin-nanocapsules) were prepared via the ionic gelation method and Lin-nanocapsules were characterized. The results of Fourier transformation infrared spectroscopy (FTIR) showed that linalool was successfully encapsulated in the wall materials. Scanning electron microscopy (SEM) results demonstrated that the shapes of Lin-nanocapsules, with smooth surfaces, were nearly spherical. Lin-nanocapsule average particle size was 352 nm and its polydispersity index (PDI) was proved to be 0.214 by the results of dynamic light scattering (DLC). Thermogravimetric results indicated that linalool loading capacity (LC) was 15.17%, and encapsulation could decrease linalool release and increase linalool retaining time under the high temperature. Oscillatory shear and steady-state shear measurements of Lin-nanocapsule emulsions were systematically investigated. The results of steady-state shear showed that Lin-nanocapsule emulsion, which was Newtonian only for high shear rate, was non-Newtonian. It was proved by oscillatory shear that when oscillation frequency changed from low to high, Lin-nanocapsules emulsion changed from viscous into elastic.Keywords: lin-nanocapsules; flavor; encapsulation; rheology.Practical Application: Lin-nanocapsules were prepared via the ionic gelation method.

show abstract

Section: Introductionmentioning

confidence: 99%

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Xiao

Zhu

2017

Food Sci. Technol

View full text Add to dashboard Cite

show abstract

“…For enhancing the ocular bioavailability, a number of formulations have been developed like gels or hydrogel, (Araujo et al, 2009) in situ gelling systems, (Badawi et al, 2008) ocuserts, (Bourlais et al, 1998) polymeric vehicles, (Anitha et al, 2011) . Hydrogels limit their value due to improper administration that is not reproducible.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Evaluation of Ketorolac Loaded Cubosome for Ocular Drug Delivery

Ali¹,

Sharma²,

Warsi³

2016

J App Pharm Sci

View full text Add to dashboard Cite

Ophthalmic formulations in terms of eye drops are more frequently used formulation for ocular disorders. But unfortunately this mode of drug instillation into the cul-de-sac of eye shows very poor ocular bioavailability (less than 5%). A large number of carrier systems have been investigated to overcome this problem. In the present study a novel nano-carrier system (Ketorolac loaded cubosomes) is developed and evaluated for the safe and enhance ocular bioavailability. Cubosomes were developed and optimized by utilizing glyceryl monooleate, poloxamer 407 and initial drug concentration. Finally developed formulation was evaluated for various In vitro characteristics i.e. particles size, size distribution, shape and morphology, in-vitro release profile, corneal permeation, corneal retention, and ocular tolerance study. The optimized drug loaded cubosomal formulation showed mean particle size, polydispersity index, and entrapment efficiency 127.3±12.23 nm, 0.205±0.011, and 53.27±5.23 %, respectively. Transmission electron microscopic analysis revealed a cubic shape of developed formulation. Further, developed formulation exhibited biphasic release profile. Significant high transcorneal permeation (2.07 folds) and corneal retention (2.24 folds) of ketorolac was observed with cubosomal formulation correspond to Ketorolac solution (p<0.01). Further safety profile of optimized formulation was evaluated by histopathology of corneal membrane. The developed novel ocular carrier system (cubosomes) might be a promising platform as a vehicle for effective ocular drug delivery.

show abstract

“…When freshly prepared, the diameters of the TPP-chitosan particles were in the range 1-1000 m (Figure 2) which is considerably larger than has been demonstrated in previous studies [4,[9][10][11][12][13][14][15] and may be explained in part by the molar mass and solubility of the chitosan. In so much as higher molecular weight chitosans produce larger particles [4,[15][16][17][18].…”

Section: Resultsmentioning

confidence: 57%

Latent Fingerprint Enhancement Using Tripolyphosphate-Chitosan Microparticles

Dueik

Morris

2013

International Journal of Carbohydrate Chemistry

View full text Add to dashboard Cite

show abstract

Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

Cited by 166 publications

References 30 publications

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Fabrication and Evaluation of Ketorolac Loaded Cubosome for Ocular Drug Delivery

Latent Fingerprint Enhancement Using Tripolyphosphate-Chitosan Microparticles

Contact Info

Product

Resources

About