Development of Mucous Glands in the Human Eustachian Tube

M, Tos

doi:10.3109/00016487009181895

Cited by 57 publications

(37 citation statements)

References 6 publications

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“…In a study conducted on 27 patients with nasal packings following nasal surgery, Johannessen and Poulsen [13] indicated that the negative pressure occurring in the middle ear returns to normal values after the nasal packings were removed, and they associated this to edema in the nasopharyngeal mucosa. In another study, eustachian dysfunction has been claimed to occur as a result of excessive secretion of the seromucous glands at the pharyngeal section of the eustachian tube [14] .…”

Section: Discussionmentioning

confidence: 99%

Is Middle Ear Pressure Effected by Nasal Packings after Septoplasty?

Şereflican¹,

Yurttaş²,

Oral³

et al. 2015

Int Adv Otol

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OBJECTIVE:To investigate the effects of different types of nasal packings on middle ear pressure in patients undergoing septoplasty. MATERIALS and METHODS:Sixty patients who were suffering from nasal obstruction and who had to undergo septoplasty because of nasal septal deviation were included in the study. After the septoplasty, Merocel packings and internal nasal splints were intraoperatively applied in thirty patients each. Middle ear pressure was evaluated by tympanometry. Tympanometric peak pressures were used for this aim. Acoustic impedance measurements were performed in both ears, and the average values of the two ears were calculated. Tympanometric measurements were performed for patients during the preoperative period and on the 2 nd and 5 th postoperative days. RESULTS:There were 30 (5 females, 25 males; average age 23 years) patients in the internal nasal splint group and 30 (8 females, 22 males; average age 26 years) patients in the anterior Merocel packing group. When the values obtained by acoustic impedancemetry before the operation and on the postoperative 5 th day were compared, there was no statistically significant difference between the groups. The middle ear pressure significantly decreased in the anterior Merocel packing group compared with that in the internal nasal splint group. The intragroup comparison of the acoustic impedance measurements of the internal nasal splint group revealed no significant difference between the preoperative acoustic impedance values and the values obtained on the postoperative 2 nd day. CONCLUSION:Cannulated silicone intranasal splints are better in terms of patient comfort after an intranasal surgery without effecting eustachian tube function.

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Section: Discussionmentioning

confidence: 99%

Is Middle Ear Pressure Effected by Nasal Packings after Septoplasty?

Şereflican¹,

Yurttaş²,

Oral³

et al. 2015

Int Adv Otol

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“…Unlike mice, ferrets and humans share a remarkably similar proximal airway cytoarchitecture (11)(12)(13). As in humans, SMGs in the ferret are distributed throughout the cartilaginous airways (12,14). Despite these similarities, however, ferret and human SMG biology differs in some respects-for example, in the timing of SMG development.…”

Section: Smgs In the Airwaymentioning

confidence: 99%

“…Despite these similarities, however, ferret and human SMG biology differs in some respects-for example, in the timing of SMG development. In humans, airway SMG development initiates when clusters of surface epithelial cells invade the lamina propria of the proximal trachea during gestation (14). In ferrets, by contrast, SMG development initiates within the trachea during the first few postnatal weeks of life, a point at which this structure closely resembles the in utero human airway at gestation stages (12,14).…”

Section: Smgs In the Airwaymentioning

confidence: 99%

“…In humans, airway SMG development initiates when clusters of surface epithelial cells invade the lamina propria of the proximal trachea during gestation (14). In ferrets, by contrast, SMG development initiates within the trachea during the first few postnatal weeks of life, a point at which this structure closely resembles the in utero human airway at gestation stages (12,14). Although the ferret is the only known placental mammal in which substantial development of both the airway epithelium and SMGs occur postnatally, these morphologic and developmental features of the ferret airway make it uniquely suited to serve as a model for studies pertaining to the development of tracheal SMGs.…”

Section: Smgs In the Airwaymentioning

confidence: 99%

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The Glandular Stem/Progenitor Cell Niche in Airway Development and Repair

Liu¹,

Engelhardt²

2008

Proceedings of the American Thoracic Society

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Airway submucosal glands (SMGs) are major secretory structures that lie beneath the epithelium of the cartilaginous airway. These glands are believed to play important roles in normal lung function and airway innate immunity by secreting antibacterial factors, mucus, and fluid into the airway lumen. Recent studies have suggested that SMGs may additionally serve as a protective niche for adult epithelial stem/progenitor cells of the proximal airways. As in the case of other adult stem cell niches, SMGs are believed to provide the localized environmental signals required to both maintain and mobilize stem/progenitor cells, in the setting of normal cellular turnover or injury. Aberrant proliferation and differentiation of glandular stem/progenitor cells may be associated with several hypersecretory lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. To better understand the molecular mechanisms that regulate the specification and proliferation of glandular stem/ progenitor cells in lung diseases associated with SMG hypertrophy and hyperplasia, researchers have begun to search for the molecular signals and cell types responsible for establishing the glandular stem/progenitor cell niche, and to dissect how these determinants of the niche change in the setting of proximal airway injury and repair. Such studies have revealed certain similarities between stem/ progenitor cell niches of the distal conducting airways and the SMGs of the proximal airways.

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“…Foldings of the surface epithelium might be considered as a part of a collecting duct of the glandular epithelium [19,20]. But it is also possible that some of these structures could be associated with a remodelling process of the surface epithelium, and could represent dynamic invaginations of the surface epithelium in the connective tissue to form new glandular structures [21], as observed during embryogenesis [20,22].…”

Section: Discussionmentioning

confidence: 99%

Identification of antileucoprotease in remodelled human adult nasal surface epithelium

Marchand

Tournier²,

Chevillard³

et al. 1995

Eur Respir J

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Antileucoprotease (ALP) is generally considered as a specific marker for glandular serous cells, and plays a major role in the defence of the respiratory tract against proteolytic damage. Nevertheless, several studies have identified ALP in bronchial and bronchiolar surface epithelial cells, and also an increased number of ALP-containing cells in bronchiolar tissue during the development of pulmonary diseases. In order to define more clearly whether the surface epithelium might be involved in the defence of the respiratory mucosa, we have investigated the expression of ALP by cells of the nasal surface epithelium.Indirect immunocytochemistry and in situ hybridization for ALP were performed on human nasal polyp sections. The height of the surface epithelium, its morphology, and the degree of local inflammation were assessed in parallel.Surface epithelium morphology was highly heterogeneous. ALP-containing cells were identified, but only in remodelled areas of the surface epithelium (foldings, basal cell and/or mucous cell hyperplasia), with no association to the degree of inflammation.These results demonstrate that the surface epithelial cells of the human adult nasal mucosa can express ALP in remodelled surface epithelium, and may be actively involved in the biochemical defence of the airways. Eur Respir J., 1995, 8, 15-21.

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Development of Mucous Glands in the Human Eustachian Tube

Cited by 57 publications

References 6 publications

Is Middle Ear Pressure Effected by Nasal Packings after Septoplasty?

Is Middle Ear Pressure Effected by Nasal Packings after Septoplasty?

The Glandular Stem/Progenitor Cell Niche in Airway Development and Repair

Identification of antileucoprotease in remodelled human adult nasal surface epithelium

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