Development of mussel mimetic gelatin based adhesive hydrogel for wet surfaces with self-healing and reversible properties

Ahmed, Asfi; Nath, Jayashree; Baruah, Kankana; Rather, Muzamil Ahmad; Mandal, Manabendra; Dolui, Swapan Kumar

doi:10.1016/j.ijbiomac.2022.12.151

Cited by 20 publications

(6 citation statements)

References 39 publications

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“…Despite its cellular adhesion properties, and even though Ma et al’s study [ 89 ] demonstrates that adding gelatin to the polyacrylic acid and polyacrylamide hydrogel enhances the hydrogel’s viscosity and adhesion to surfaces like glass and plastic, the tissue adhesive properties of gelatin are insufficient [ 90 ]. Therefore, it is often functionalized with dopamine, imparting adhesive properties to the hydrogel due to its structural resemblance to mussel adhesive proteins [ 88 , 95 , 96 ]. The key to the good adhesive properties of mussels lies in the abundance of catechol groups [ 88 ].…”

Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

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Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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“…25 Traditional hydrogels, without specialized design, typically lack the essential self-adhesive strength, which require extra adhesives such as bandages, scotch tape, or 3M products to fix them on the skin surface. 26 So far, numerous efforts have been made to enhance the adhesion of hydrogels, e.g., addition of viscous monomers or groups to the hydrogel systems. 27,28 While these methods can effectively improve the hydrogel adhesion, an alteration in the composition can inadvertently influence their mechanical properties and other performances, such as temperature and electrochemical responsiveness.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

Zhang,

Ding,

et al. 2024

Mater. Horiz.

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“…Hydrogel-based electronic devices have garnered growing interest as a result of their remarkable flexibility and extensibility [ 9 ]. Previously, a lot of functional hydrogels have been prepared from gelatin [ 10 ], chitosan [ 11 ], sodium alginate [ 12 ], and other biomass through physical cross-linking, such as electrostatic interaction and hydrogen bonding. Alternatively, hydrogels can be produced through the process of chemical cross-linking using covalent interactions, for example, acrylamide (AM) and acrylic acid (AA) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Dual-Network Polymer Hydrogels with Anti-Freezing, Highly Conductive, and Self-Healing Properties

Jin,

Zhao,

Jiang

et al. 2024

Materials

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We report the synthesis of poly(acrylamide-co-acrylic acid)/sodium carboxy methyl cellulose (PAMAA/CMC-Na) hydrogels, and subsequent fabrication of dual-network polymer hydrogels (PAMAA/CMC-Na/Fe) using as-prepared via the salt solution (FeCl3) immersion method. The created dual-network polymer hydrogels exhibit anti-swelling properties, frost resistance, high conductivity, and good mechanical performance. The hydrogel swells sightly when immersed in solution (pH = 2~11). With the increase in nAA:nAM, the modulus of elasticity experiences a rise from 1.1 to 1.6 MPa, while the toughness undergoes an increase from 0.18 to 0.24 MJ/m3. Furthermore, the presence of a high concentration of CMC-Na also contributes to the enhancement of mechanical strength in the resulting hydrogels, ascribing to enhanced physical network of the hydrogels. The minimum freezing point reaches −21.8 °C when the CMC-Na concentration is 2.5%, owing to the dissipated hydrogen bonds by the coordination of Fe3+ with carboxyl (-COO−) in CMC-Na and PAMAA. It is found that the conductivity of the PAMAA/CMC-Na/Fe hydrogels gradually decreased from 2.62 to 0.6 S/m as the concentration of CMC-Na rises. The obtained results indicates that the dual-network hydrogels with high mechanical properties, anti-swelling properties, frost resistance, and electrical conductivity can be a competitive substance used in the production of bendable sensors and biosensors.

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Development of mussel mimetic gelatin based adhesive hydrogel for wet surfaces with self-healing and reversible properties

Cited by 20 publications

References 39 publications

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

Facile Synthesis of Dual-Network Polymer Hydrogels with Anti-Freezing, Highly Conductive, and Self-Healing Properties

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