Development of Na-CN—κ-carrageenan Microbeads for the Encapsulation of Lipophilic Compounds

Perrechil, Fabiana de Assis; Vilela, Joice Aline Pires; Guerreiro, Lizielle Maria Ricardo; Cunha, Rosiane L.

doi:10.1007/s11483-012-9265-0

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…For the particles formed in a 3% (m/m) CaCl 2 bath, the samples produced with lower air pressure (0.25 bar) showed irregular morphology, greater aggregation and fractured particles. This pressure may not have been enough to break the surface tension between the alginate solution flow and the air during droplet formation (Perrechil et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Effect of crosslinking and atomization parameters on the properties of alginate microparticles formed by ionic gelation

Fiocco¹,

Sato²,

Picone³

2023

JER

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Sodium alginate is a non-toxic, biodegradable polysaccharide with high gelling capacity that makes it an excellent material for the development of delivery systems for drugs and bioactive compounds and various environmental applications. In this study, alginate microparticles were prepared through ionic gelation by atomization, varying the concentration of the CaCl 2 bath (3 and 6% m/m), air pressure (0.25 and 0.50 bar) and spraying distance (20 and 25 cm). The microparticles obtained were evaluated for size distribution, surface morphology and stability against different pHs (pH 2.5, 3.5 and 4.5) for 4 days. The atomization process produced particles with sizes between 83 and 146 μm with different morphologies (irregular, spherical or elliptical). It was observed that the particles produced with 0.25 bar underwent changes in size and morphology after 4 days depending on the pH of the medium. Samples produced at a concentration of 6% CaCl 2 showed larger sizes when compared to those formed with 3%, possibly due to the greater ionic strength of the solution. As for the spraying height, the samples produced at 25cm had a more spherical morphology than the others. These results allow the development of microparticles with desirable properties from the control of the conditions of the atomization and reticulation process.

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Section: Resultsmentioning

confidence: 99%

Effect of crosslinking and atomization parameters on the properties of alginate microparticles formed by ionic gelation

Fiocco¹,

Sato²,

Picone³

2023

JER

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“…An important parameter for the definition of particle diameters is the pH of the solution. Carrageenan biopolymer has been used in the same way and it was reported that the pH has a greater influence on the diameter of the microparticles than the diameter of the spray nozzle, and that the diameters were 90 and 120 µm for pH 7 and 3.5, respectively …”

Section: Resultsmentioning

confidence: 99%

“…The density was determined by pycnometry using density bottles of 25 mL. The average diameter of the particles was analysed in triplicate by means of the particle size distribution obtained using distilled water as the dispersing medium in a laser diffraction Mastersizer 2000 equipment (Malvern Instruments Ltd, UK), using the Fraunhofer theory based on the proportion volume/mean surface

((), d_{p} = d_{32} = true \sum n_{i} d_{i}^{3} true/ true \sum n_{i} d_{i}^{2})

, where n i is the number of microcapsules of diameter d i . The pore structure was measured by the mercury porosimetry technique, using a Micromeritics 9400 porosimeter (Micromeritics Instrument Corporation, USA) with the following parameters for the phases of low and high pressure: evacuation pressure = 50 000 µmHg; evacuation time = 30 min; equilibrium time = 10 s. The particle porosity was calculated from the following equation: ϵ p = 1 − ( ρ bulk / ρ p ).…”

Section: Methodsmentioning

confidence: 99%

Development and characterization of a new adsorbent for biomolecule separation: intercalation and adsorption of clavulanic acid in layered double hydroxides

Forte

Taviot-Guého

Leroux

et al. 2015

J of Chemical Tech & Biotech

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BACKGROUND: A new layered double hydroxide (LDH) material has been developed through a pioneering approach, with the goal of being an alternative adsorbent for the separation of biomolecules, such as clavulanic acid (CA). RESULTS: Zn 2 Cr-CA hybrid LDH assemblies were prepared through a coprecipitation method to evaluate the affinity between the CA molecule and the interlayer sites. The resulting inorganic-organic 'sandwich' structure was characterized by a combination of techniques showing an expansion of the layered structure from 0.78 nm up to values of 2.30 nm upon CA intercalation. Isotherm studies were carried out to evaluate the adsorption capacity of LDH towards CA. The Freundlich adsorption model was found to fit the experimental data well, indicating a relatively large adsorption capacity for the adsorbent Zn 2 Cr-NO 3 , as high as 73.63, 128.76, and 229.62 mg 1-nF L nF g −1 at 20, 30, and 35 ∘ C, respectively. CONCLUSION: Zn 2 Cr-NO 3 adsorption capacity was not influenced by the presence of amino acids, thus underlining that it is a LDH composition which may be a suitable alternative for the separation of CA. LDH micro-particles were additionally encapsulated with calcium alginate gel (LDH ME ) and characterized for particle average diameter (d p = 171 m), bulk density ( bulk = 0.63 g cm −3 ), particle density ( p = 2.2 g cm −3 ), particle porosity ( p = 0.71) and bed porosity ( B = 0.40). The application of LDH ME in the separation of CA from complex mixtures, containing tyrosine and proline, was considered satisfactory based on purification factors of about 2.32 and degrees of purity higher than 99%. Analytical methodsThe CA concentrations were determined by spectrophotometric analysis of the product of the reaction of CA with imidazole. 31

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“…Um parâmetro bastante importante na definição desses diâmetros é o pH. Pesquisadores, usando sistemas com carragena como biopolímero, observaram que o pH influenciou mais no diâmetro das micropartículas formadas do que o diâmetro do bico aspersor, reportando diâmetros de 90 e 120 µm para pH 7,0 e 3,5, respectivamente (Perrechil et al, 2012).…”

Section: Preparação E Caracterização Dos Adsorventes Ldhunclassified

Estudo da adsorção de ácido clavulânico em hidróxidos duplos lamelares

Forte¹

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vi vii "Aprender é a única coisa de que a mente nunca se cansa, nunca tem medo e nunca se arrepende." Leonardo da Vinci. viii ix Dedico esta Tese de Doutorado a minha mãe, Guiomar Soares Maia Forte (in memoriam), a minha avó e mãe, Antônia Maria de Lima e a minha sobrinha, Laura Forte. x ___________________________________________________________________________Agradecimentos xi AGRADECIMENTOS Primeiramente, eu gostaria de agradecer a DEUS! Pela força divina que alimenta minha alma! Aos meus queridos orientadores, Francisco Maugeri Filho e Maria Isabel Rodrigues. Sinceramente, é difícil estabelecer um critério para listar os motivos de agradecimentos a vocês. Sem dúvida alguma, grande parcela de meu crescimento profissional e pessoal deve-se a vocês. Muito obrigado pela presença, cumplicidade, transmissão de conhecimento, paciência, compreensão e principalmente por todas as oportunidades que vocês me disponibilizaram de aprender e ensinar, não só no campo profissional. Podem ter certeza que irei passar tudo isso para frente com responsabilidade. Sou muito orgulhoso de ter trabalhado e convivido com vocês durante esses anos. Muito obrigado de coração!

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Development of Na-CN—κ-carrageenan Microbeads for the Encapsulation of Lipophilic Compounds

Cited by 13 publications

References 24 publications

Effect of crosslinking and atomization parameters on the properties of alginate microparticles formed by ionic gelation

Effect of crosslinking and atomization parameters on the properties of alginate microparticles formed by ionic gelation

Development and characterization of a new adsorbent for biomolecule separation: intercalation and adsorption of clavulanic acid in layered double hydroxides

Estudo da adsorção de ácido clavulânico em hidróxidos duplos lamelares

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