Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation

Palacios, Luna R. Gomez; Bracamonte, A. Guillermo

doi:10.1039/d2ra02008d

Cited by 22 publications

(9 citation statements)

References 130 publications

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“…Likewise, developments of implantable technology based on biocompatible photonic substrates. 92,93 In addition, electrical signalling detection and molecular tracking applied to tissues and organs as in biological event detections to generate bioimaging, early diagnosis, and also to optimize mechanical movements by prosthesis. Hence, there is a broad spectrum of needs and interests that should be addressed by the next generation of therapeutics and new precision medicine accessed through implantable devices and encapsulated multi-functional therapeutic nano-and micromaterials.…”

Section: Discussionmentioning

confidence: 99%

Implantable Devices, Nano-, and Micro-Capsules for Future Nanomedicine and Life Sciences Nano-Tools

Gomez Palacios,

Amé,

Martinez

et al. 2023

Preprint

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In this communication the concept of functional materials is understood such as real modified substrates for nanomedicine applications. Functional and modified substrates focused on microcapsules and devices for new nanomedicine diagnosis and treatments. Cases of different materials are shown to support the functionality strategy, as in particular chemicals, pharmacophores, and controlled nano-chemistry for the design of nanoplatforms. Recent studies have reported hybrid inorganic/organic compositions for biocompatible, biodegradable, and support materials added to particular physical properties such as conductive, semiconductive, and high electromagnetic fields from the near field within the nanoscale to far-field applications and new nano-pharmacophores and nanomedicine therapeutics. New approaches are shown from the nano-scale to the micro- and higher sizes of substrates for improved therapeutic strategies. Micro-capsules for biosensing and drug delivery applications were developed. In addition, we report recent and novel research centered on implantable, portable, and wearable devices applied to future treatments.

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Section: Discussionmentioning

confidence: 99%

Implantable Devices, Nano-, and Micro-Capsules for Future Nanomedicine and Life Sciences Nano-Tools

Gomez Palacios,

Amé,

Martinez

et al. 2023

Preprint

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“…Henceforth, it is crucial to subject these parameters to critical analysis. However, there is currently a lack of standardized methodologies for evaluating hydrophobicity, quantifying and assessing the homogeneity of surface functionalities, and determining the surface area, making it a great challenge for scientists [ 76 ]. Additionally, analyzing the drug loading and release potential of nanoparticles and hydrogels is a notable challenge.…”

Section: Challenges Associated With Nanoformulationsmentioning

confidence: 99%

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Dwivedi,

Mandal,

Afzal

et al. 2023

Gels

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Flavonoids are hydroxylated phenolic substances in vegetables, fruits, flowers, seeds, wine, tea, nuts, propolis, and honey. They belong to a versatile category of natural polyphenolic compounds. Their biological function depends on various factors such as their chemical structure, degree of hydroxylation, degree of polymerization conjugation, and substitutions. Flavonoids have gained considerable attention among researchers, as they show a wide range of pharmacological activities, including coronary heart disease prevention, antioxidative, hepatoprotective, anti-inflammatory, free-radical scavenging, anticancer, and anti-atherosclerotic activities. Plants synthesize flavonoid compounds in response to pathogen attacks, and these compounds exhibit potent antimicrobial (antibacterial, antifungal, and antiviral) activity against a wide range of pathogenic microorganisms. However, certain antibacterial flavonoids have the ability to selectively target the cell wall of bacteria and inhibit virulence factors, including biofilm formation. Moreover, some flavonoids are known to reverse antibiotic resistance and enhance the efficacy of existing antibiotic drugs. However, due to their poor solubility in water, flavonoids have limited oral bioavailability. They are quickly metabolized in the gastrointestinal region, which limits their ability to prevent and treat various disorders. The integration of flavonoids into nanomedicine constitutes a viable strategy for achieving efficient cutaneous delivery owing to their favorable encapsulation capacity and diminished toxicity. The utilization of nanoparticles or nanoformulations facilitates drug delivery by targeting the drug to the specific site of action and exhibits excellent physicochemical stability.

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“…Nowadays, various nanomaterials have been used for delivery of therapeutic drugs to tumor site. 25 Among different nanomaterials such as liposome, metallic, dendrimers, polymers, hydrogels and so forth, protein-based nanocarriers are actively used in pharmaceutical science. 26,27 Albumin proteins are versatile nanocarriers and have advantageous properties like biocompatibility, biodegradability, non-immunogenic, non-toxicity and high drug-binding capacity.…”

Section: Introductionmentioning

confidence: 99%

Folate conjugated albumin as a targeted nanocarrier for the delivery of fisetin: in silico and in vitro biological studies

Solanki,

Srivastav,

Patel

et al. 2024

RSC Adv.

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Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation

Cited by 22 publications

References 130 publications

Implantable Devices, Nano-, and Micro-Capsules for Future Nanomedicine and Life Sciences Nano-Tools

Implantable Devices, Nano-, and Micro-Capsules for Future Nanomedicine and Life Sciences Nano-Tools

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Folate conjugated albumin as a targeted nanocarrier for the delivery of fisetin: in silico and in vitro biological studies

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