Development of nano-immunotherapy for cancer treatment: achievements and scopes

Raj, Akhil; Babu, Amal; Kothandan, Vinoth Kumar; Park, In-Kyu; Hwang, Seung Rim

doi:10.1007/s40005-023-00644-9

J. Pharm. Investig.

2023

DOI: 10.1007/s40005-023-00644-9

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Development of nano-immunotherapy for cancer treatment: achievements and scopes

Akhil Raj,

Amal Babu,

Vinoth Kumar Kothandan

et al.

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2024

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Cited by 3 publications

References 152 publications

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Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites

Kim,

Choi

2024

J. Pharm. Investig.

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Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites

Kim,

Choi

2024

J. Pharm. Investig.

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Catechol-modified stabilizer facilitates impulsive ligand functionalization of particulates and membrane modification of cells

Shrestha,

Pathak,

Regmi

et al. 2024

Journal of Drug Delivery Science and Technology

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Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma

Babu,

Padmanaban,

Chahal

et al. 2024

J Nanobiotechnol

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The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% of liver cancers, poses a significant health burden. The effectiveness of traditional hepatocellular carcinoma treatments such as surgical resection, radiotherapy, and chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) and R848 (resiquimod; a TLR7/8 agonist) (PIR NPs). Characterization confirmed the size and loading capacity of PIR NPs, and controlled release of R848 therefrom upon NIR irradiation, thereby establishing the potential of this versatile therapeutic tool. PIR NPs were readily taken up by Hepa 1–6 cells in vitro by targeting asialoglycoprotein receptors present on its cellular surface. In in vivo experiments combining photothermal therapy and immunotherapy, following the local near-infrared irradiation, the PIR NPs accumulated in tumor sites induced immunogenic cell death and activated a tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. The combined efficacy of photothermal therapy and immunotherapy presents a promising avenue for addressing the shortcomings of traditional hepatocellular carcinoma interventions. This study contributes valuable insights into the development of more effective and targeted therapeutic approaches for hepatocellular carcinoma treatment. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12951-024-03030-1.

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Development of nano-immunotherapy for cancer treatment: achievements and scopes

Cited by 3 publications

References 152 publications

Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites

Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites

Catechol-modified stabilizer facilitates impulsive ligand functionalization of particulates and membrane modification of cells

Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma

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