Development of nanomaterials for bone-targeted drug delivery

Cheng, Hao; Chawla, Aditya; Yang, Yafeng; Li, Yuxiao; Zhang, Jin; Jang, Hae Lin; Khademhosseini, Ali

doi:10.1016/j.drudis.2017.04.021

Cited by 117 publications

(87 citation statements)

References 154 publications

(229 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their use resulted in most cases in reduced rate of complications, operative times, operative costs, and hospital length of stay, along with comparable or better results in term of clinical and radiological outcomes [8,[38][39][40][41]. Furthermore, xenohybrid materials demonstrated that can be successfully used as carriers to locally administer drugs or MSCs, making them a useful resource for orthopaedic surgeons, in a variety of conditions [7,20,44,45]. Hence, more clinical studies to better understand the role of biomaterials in orthopaedic surgery are encouraged.…”

Section: Discussionmentioning

confidence: 99%

Composite Xenohybrid Bovine Bone-Derived Scaffold as Bone Substitute for the Treatment of Tibial Plateau Fractures

et al. 2019

View full text Add to dashboard Cite

Introduction: Tibial plateau fractures represent a common challenge for orthopaedic surgeons, sometimes representing complex cases to manage, where augmentation using bone grafts is required for stabilisation. Autologous iliac bone graft (AIBG) is the current gold standard for bone grafting. In order to overcome limitations related to the procedure, alternative strategies, like allogenic and xenogeneic bone substitutes have been investigated. Here, within the framework of an observational clinical study, we report clinical and radiological outcomes of patients treated for tibial plateau fractures with a composite xenohybrid bone graft, aiming at assessing clinical and radiological outcomes. Materials and Methods: We performed a cohort retrospective study of patients treated for tibial plateau fractures from May 2017 to January 2018. Thirty-four patients, i.e. 100% of those having received the bone graft under investigation for tibial plateaux fracture treatment, met the inclusion criteria and were enrolled in the study. Patients were assessed at 2 weeks, and then at a 1-, 3-, and 6-months, and 1-year follow-up. At each evaluation patients filled a visual analogue scale (VAS) for the level of pain during the day life activities and underwent physical exam and anteroposterior and lateral projection radiographs of the knee. At 1 year the Tegner Lysholm Scoring Scale, International Knee Document Committee 2000 (IKDC 2000), and Short Form (36) Health Survey (SF-36) were administered. Results: At 1-year, mean VAS decreased from 6.33 ± 1.40 to 1 ± 0.79 (P < 0.0001); Tegner Lysholm Scoring Scale was 89 ± 4.10 and mean IKDC 2000 was 78.67 ± 3.31. No infections, neurovascular complications or adverse effects related to implants were reported during the clinical exams at follow-up. Mean ROM was 124 ± 6°. Radiographs did not show defects of consolidation or progressive post-surgical subsidence and demonstrated a good grade of integration of the implant. Conclusions: Clinical and radiological outcomes, and scores of questionnaires, were good. The xenograft has demonstrated to be a safe biomaterial, with satisfactory mechanical and biological performances in the mid-term period. It also showed a high grade of osteointegration and remodelling.

show abstract

Section: Discussionmentioning

confidence: 99%

Composite Xenohybrid Bovine Bone-Derived Scaffold as Bone Substitute for the Treatment of Tibial Plateau Fractures

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Lipid nanoparticles (LNPs), have great potential in comparison with inorganic nanoparticles, due to their biocompatibility and low toxicity. LNPs are uniform nano-carriers including solid- and liquid-state lipids, that can be organized into a core-shell or homogeneous particle structure [ 27 ]. They include lipid drug conjugate (LDC) carriers, nanostructured lipid carriers (NLCs), lipid nanocapsules carriers (LNCs) and solid lipid nanoparticle (SLN) carriers [ 28 ].…”

Section: Biomaterials For Bone Scaffoldsmentioning

confidence: 99%

“…MSN-based multifunctional drug delivery systems are able to deliver antitumor drugs in a targeted fashion and release them on demand to increment their cellular uptake without any premature release prior to reaching the target site [ 31 ]. They can accelerate bone formation by upregulating osteoblast activity and decreasing bone resorption by downregulating osteoclast activity; for this reason they are still a great option for treating osteoporosis [ 27 ].…”

Section: Biomaterials For Bone Scaffoldsmentioning

confidence: 99%

“…Nanodiamonds (NDs) are octahedral, nanoscale carbon allotropes that are perfect intracellular carriers of bioactive compounds because of their properties such as: biocompatibility, reduced dimensions and high surface chemical interaction [ 27 ]. NDs have been suggested to have a positive role in osteoblast proliferation and differentiation but appears to have gained overall not much interest for long term translational studies [ 36 ].…”

Section: Biomaterials For Bone Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Scaffolds as Structural Tools for Bone-Targeted Drug Delivery

et al. 2018

View full text Add to dashboard Cite

Although bone has a high potential to regenerate itself after damage and injury, the efficacious repair of large bone defects resulting from resection, trauma or non-union fractures still requires the implantation of bone grafts. Materials science, in conjunction with biotechnology, can satisfy these needs by developing artificial bones, synthetic substitutes and organ implants. In particular, recent advances in materials science have provided several innovations, underlying the increasing importance of biomaterials in this field. To address the increasing need for improved bone substitutes, tissue engineering seeks to create synthetic, three-dimensional scaffolds made from organic or inorganic materials, incorporating drugs and growth factors, to induce new bone tissue formation. This review emphasizes recent progress in materials science that allows reliable scaffolds to be synthesized for targeted drug delivery in bone regeneration, also with respect to past directions no longer considered promising. A general overview concerning modeling approaches suitable for the discussed systems is also provided.

show abstract

“…Fibrous nanomaterials are important for many potential applications including: wound dressing (Hassiba et al ., ); filtration, including air filtration (Al‐Attabi et al ., ); biosensors (Pasinszki et al ., ); tissue engineering such as skin tissue engineering (Jiang et al ., ) and targeted drug delivery to, e.g. bone (Cheng et al ., ). Fibres are also naturally occurring in plants, and in animals, see, e.g.…”

Section: Introductionmentioning

confidence: 97%

Automatic diameter and orientation distribution determination of fibrous materials in micro X‐ray CT imaging data

Chiverton

Kao

Roldo

et al. 2018

Journal of Microscopy

View full text Add to dashboard Cite

Fibrous nanomaterials such as electrospun materials have many uses ranging from tissue engineering to biosensors. High-resolution imaging is an important component in the characterization of these materials. Important parameters required to predict and study the properties of fibre rich materials include diameter and orientation distribution as well as fibre spacing. The orientations and the relative dimensions of the fibres can be measured via specially designed imaging software. Difficulties in this measurement process can arise if fibres are distributed in close proximity to each other in relation to the resolution of the imaging modality. For example, if some automation is required in the measurement process and, particularly, if the automated processes are not designed for situations where the fibres are in close proximity to each other. This work is therefore concerned with the development of automated measurement techniques to provide estimates of the diameters of fibres and also the orientation distribution. The software automatically detects special points in the fibrous materials where fibres can be considered to have some delineation from surrounding fibres. These sparse points are considered to be points at which estimates of the fibres' properties can be quantified. Aligned and randomly distributed electrospun poly(caprolactone) nanofibres were prepared. Imaging of these materials was performed with an X-ray Computer Tomography system with an image voxel size of 0.15 × 0.15 × 0.15 μm . Scanning Electron Microscopy images were also obtained. Fibre diameters estimated using images from both modalities using the developed techniques were found to be in agreement. Orientation distribution was summarized with multiscale entropy and found to be consistent with visual observation across different scales. LAY DESCRIPTION: Fibres are present in many types of materials which can include, for some materials, very small fibres e.g. a few nanometres in diameter. Very small fibres are present in collagen and elastin which are common tissues of many organs in many types of living things. The sizes of these very small fibres and how they are arranged are important information that can help in the understanding of the overall properties of these materials. Materials with very small fibres can also be synthesized using specialised techniques. The properties of these synthesized fibrous materials are also important to help in understanding how the materials will perform in various different applications. Applications are many and can range from tissue engineering to drug delivery. Some properties of these materials can be shown, visually, with the aid of 3D imaging techniques such as X-ray Computer Tomography (XCT) or in 2D, with Scanning Electron Microscopy (SEM) but at a higher magnification. The work described here is centred around the development of computer algorithms to automatically determine material properties from 3D XCT images. Tests are performed with material samples, where the fibres are aligned (in semi...

show abstract

Development of nanomaterials for bone-targeted drug delivery

Cited by 117 publications

References 154 publications

Composite Xenohybrid Bovine Bone-Derived Scaffold as Bone Substitute for the Treatment of Tibial Plateau Fractures

Composite Xenohybrid Bovine Bone-Derived Scaffold as Bone Substitute for the Treatment of Tibial Plateau Fractures

Scaffolds as Structural Tools for Bone-Targeted Drug Delivery

Automatic diameter and orientation distribution determination of fibrous materials in micro X‐ray CT imaging data

Contact Info

Product

Resources

About