Development of nanoparticulate formulation of coenzyme Q10 and comparison of plasma coenzyme Q10 response in a single supplementation with regular coenzyme Q10 using rats

Preparation, in-vitro and in-vivo characterisation of CoQ10 microparticles: electrospraying-enhanced bioavailability

“…The presence of dual‐plasma peak concentrations, termed as the Double Peak Phenomenon can be attributed to three main causes, namely, enterohepatic recycling, delayed gastric emptying or variability of absorption . This phenomenon has been reported in previous CoQ 10 studies engaging oral administration, attributing it to enterohepatic recycling. Despite extending blood collection to 120 h after oral administration of the three formulations, the present study did not observe an elimination phase.…”

“…The plasma CoQ10 level did not completely reach baseline, thus making it difficult to calculate the half‐life of exogenous CoQ10 in this study. In this study, the absence of elimination phase despite having extended the observation period compared to previous studies, could be due to the higher dose used in this study.…”

“…Earlier animal studies have shown the advantage of reduced particle size in delivery and absorption of CoQ10 . The study by Hatanaka et al .…”

Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the Solubility and Antioxidant Activity of Confined Coenzyme Q10

“…Therefore, there are limited reports trying to prepare oral nanoformulation of CoQ10. Several strategies, including particle size reduction, emulsification, preparation of solid dispersions, mitochondria-targeting moiety-based formulations, and the use of nano-/microcarrier formulations based on liposomes, polymer particles, and microspheres, have been employed to enhance the solubility of Q10 and increase its adsorption and bioavailability in the lumen. − MSNs have demonstrated the ability to improve the solubility and bioavailability of poorly soluble drugs, such as ibuprofen, griseofulvin, nimodipine, valsartan, carbamazepine, itraconazole, simvastatin, and complementary medicines such as curcumin and resveratrol. − However, to the best of our knowledge, there has been no report of using MSNs for improving the solubility of Q10. Despite the increasing interest in using mesoporous silica nanoparticles (MSNs) as drug delivery systems, to date, no study has investigated the potential of MSNs to enhance the solubility of Q10.…”