Development of natural anti-tumor drugs by microorganisms

Chang, Chia‐Che; Chen, Wei‐Chuan; Ho, Tsing-Fen; Wu, Ho‐Shing; Wei, Yuhong

doi:10.1016/j.jbiosc.2010.12.026

Cited by 92 publications

(69 citation statements)

References 105 publications

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“…This result is in accordance with the previously reported propensity of PGs to induce apoptosis. It has been shown that prodigiosins modulate the expression of Bcl-2 family proteins, IAP proteins, and death ligand/ receptors involving both mitochondrial and death-receptor apoptotic pathways (19). The influence of UPP on radiationinduced MNi formation appeared to be concentration dependent.…”

Section: Discussionmentioning

confidence: 94%

“…It has been reported that PGs mainly target cancer cells (hematopoietic, gastrointestinal, breast, and lung cancer) with little or no effects on normal cells (16)(17)(18). Numerous studies indicated that PGs displayed selective cytotoxicity against cancer cells, anti-metastatic activity, and p53-independent proapoptotic effects, which points to their potency as anticancer agents (16,19).…”

mentioning

confidence: 99%

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The impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitro

Petrović

Vasic

Mitrović

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Undecylprodigiosin pigment (UPP) is reported to display cytotoxic activity towards various types of tumours. Nevertheless, its efficacy in modifying the cellular response to ionising radiation is still unknown. In this study, the radiomodulating effects of UPP were investigated. The effects of UPP were assessed in vitro by treating cultures of human peripheral blood with UPP and ionising radiation using two treatment regimens, the UPP pre-irradiation treatment and UPP post-irradiation treatment. The activity of UPP was investigated evaluating its effects on the radiation-induced micronuclei formation, cell proliferation, and induction of apoptosis. The redox modulating effects of UPP were examined measuring the catalase activity and the level of malondialdehyde, as a measure of oxidative stress. The results showed that UPP effects on cellular response to ionising radiation depend on its concentration and the timing of its administration. At low concentration, the UPP displayed radioprotective effects in γ-irradiated human lymphocytes while at higher concentrations, it acted as a radiosensitiser enhancing either mitotic catastrophe or apoptosis depending on the treatment regimen. The UPP modified redox processes in cells, particularly when it was employed prior to γ-irradiation. Our data highlight the importance of further research of the potential of UPP to sensitize tumour cells to radiation therapy by inhibiting pathways that lead to treatment resistance.

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

The impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitro

Petrović

Vasic

Mitrović

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…As was found later, this supposition was not correct, for the pyrogenicity was not the main curative effect and beneficial outcomes of Coley's toxin relate to function manifestation of interleukin IL-12 (Tsung and Norton, 2006) or tumoricidal activities of pigments prodigiosins (Chang et al, 2011;Stankovic et al, 2014;Darshan and Manonmani, 2015). However, during past times the mentioned supposition led to an attempt to replace the arguable intact microbes, though inactivated, by isolated and purified lipopolysaccharides.…”

Section: Lipopolysaccharidementioning

confidence: 99%

From Hyperthermia to Immunomodulating Polysaccharides

Novák¹,

Větvička²

2017

American Journal of Immunology

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Natural polysaccharides remain overlooked as part of naturally occurring bioactive molecules. The current knowledge results in numerous clinical trials, from first observations of their effects on various diseases to precise chemical characterization and decades of biological evaluation. The aim of this report is to summarize historical perspective of the route from the first anecdotical observation to the current position, with emphasis on some crucial turning points.

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“…Extracellular heteropolysaccharides, for instance, are growth-associated substances produced by many species of lactic acid bacteria (Degeest et al 2001) as are xanthan gum produced by Xanthomonas campestris (Faria et al 2010), or polyhydroxybutyric acid, by Alcaligenes eutrophus (Smets et al 2004). The ability to maintain cells in a particular metabolic or physiological state related to μ, promoting a particular metabolism for the production of secondary metabolites, such as prodigiosins (Chang et al 2011), is of particular relevance to biotechnology and pharmaceutical industries. Generally speaking, the specific productivity, recombinant protein production rate, and secretory expression in carbon-limited fed-batch cultures is often inversely correlated to the specific growth rate of the microorganism (Jenzsch et al 2006)-hence the importance of maintaining low specific growth rates, at least during protein expression phase, to maximize product yield (Panda et al 1999;Hellwig et al 2001;Priego-Jimenez et al 2005;Ren and Yuan 2005;Jenzsch et al 2006;Babaeipour et al 2007;Min et al 2010;Puertas et al 2010).…”

Section: Product Formation Rate and Product Quantitymentioning

confidence: 99%

Real-time monitoring and control of microbial bioprocesses with focus on the specific growth rate: current state and perspectives

Schuler

Marison

2012

Appl Microbiol Biotechnol

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Understanding the growth characteristics of microorganisms is an essential step in bioprocessing, not only because product formation may be growth-associated but also because they might influence cell physiology and thereby product quality. The specific growth rate, a key variable of many bioprocesses, cannot be measured directly and relies on the estimation through other measurable variables such as biomass, substrate, or product concentrations. Techniques for real-time estimation of the specific growth rate in microbial fed-batch cultures are discussed in the present paper. The advantages and limitations of different models and various monitoring techniques are discussed, highlighting the importance of the specific growth rate in the development of fast, reliable, and robust processes for the production of high-value products such as recombinant proteins.

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Development of natural anti-tumor drugs by microorganisms

Cited by 92 publications

References 105 publications

The impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitro

The impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitro

From Hyperthermia to Immunomodulating Polysaccharides

Real-time monitoring and control of microbial bioprocesses with focus on the specific growth rate: current state and perspectives

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