2023
DOI: 10.3390/jfb14020105
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Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds

Abstract: Augmenting the vascular supply to generate new tissues, a crucial aspect in regenerative medicine, has been challenging. Recently, our group showed that calcium phosphate can induce the formation of a functional neo-angiosome without the need for microsurgical arterial anastomosis. This was a preclinical proof of concept for biomaterial-induced luminal sprouting of large-diameter vessels. In this study, we investigated if sprouting was a general response to surgical injury or placement of an inorganic construc… Show more

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