Development of new coronary atherosclerotic lesions during a 4-year multifactor risk reduction program: The stanford coronary risk intervention project (SCRIP)

Abstract

These data indicate that intensive multifactor risk reduction tends to diminish the frequency of new coronary lesion formation.

A Practical and Evidence-Based Approach to Cardiovascular Disease Risk Reduction

“…129 To address this, specialized programs dedicated to simplifying multifactor CV risk reduction have been developed, resulting in significant improvements in clinical outcomes. [130][131][132][133] In spite of this a patient diagnosed with CVD today can be expected to take as many as 5 or more medications to achieve optimal risk reduction. Limited by cost, concerns about compliance, and the potential for drug-drug interaction, some physicians remain skeptical of the benefits derived from this form of CV polypharmacy.…”

Diet and coronary heart disease: Clinical trials

“…The Stanford Coronary Risk Intervention Project (SCRIP) followed 300 men and women with CHD for 4 years, comparing multifactor risk reduction with usual care [47,48]. The intervention group was counseled to consume a low total fat (less than 20%), low saturated fat (less than 6%), low cholesterol (less than 75 mg/d) diet and exercise was also encouraged.…”

LDL-cholesterol lowering and atherosclerosis - clinical benefit and possible mechanisms: an update

“…Evidently, there seems to be a dissociation between the results of angiographic studies and clini cal outcome: lipid-lowering therapy has been shown to reduce the incidence of cardiovascular events with only small changes in coronary anatomy [98,99]. Therefore, it is most likely that treatment of hypercholesterolaemia depletes the lipid core of early atheromatous plaques, and consequently stabilizes these lipid-rich lesions and prevents further compli cations such as intramural haemorrhage and intralu minal thrombosis, an assumption that has been demonstrated in the Canadian Coronary Atheroscle rosis Intervention Trial (CCAIT) and the Stanford Coronary Risk Intervention Project (SCRIP) [28,100].…”