Development of new indole-derived neuroprotective agents

Mohareb, Rafat M.; Ahmed, Hanaa H.; Elmegeed, Gamal A.; Abdelhalim, Mervat M.; Shafic, Reham W.

doi:10.1016/j.bmc.2011.03.031

Cited by 22 publications

(6 citation statements)

References 38 publications

(36 reference statements)

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“…In the scope of research program aimed at the development of new alternatives to treat neurological disorders [10,17,18]. We described in this study the synthesis of new candidates for regression of AD in experimental animal model.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Elmegeed¹,

Ahmed²,

Hashash

et al. 2015

Steroids

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Section: Introductionmentioning

confidence: 99%

Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Elmegeed¹,

Ahmed²,

Hashash

et al. 2015

Steroids

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“…引入四唑环片段的吲哚类化合物 78 具有较强抗氧化和自由基清除作用, 通过抑制脂质过氧化产物含量、增强抗氧化酶活性和诱导 GSH 的合成来抑制氧化应激反应的发生. 四唑环和吲哚环的同时存在使其抗氧化活性显著增强 [98] . [101] .…”

Section: Scheme 10unclassified

Recent Advances in the Synthesis and Application of Tetrazoles

Cui¹,

Damu²,

Guri³

et al. 2013

Chin. J. Org. Chem.

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Tetrazole is an important five-membered aromatic heterocycle with poly-nitrogen electron-rich planar structural feature. This unique structure endows tetrazole derivatives as drugs, explosives, functional materials etc. to exhibit wide potential applications in medicinal, agrochemical, material science and so on. Relevant researches have been becoming active and some important achievements have been made. Based our work on azoles and referring to other literature in recent 5 years, this review systematically summarized the recent advances in the synthesis of tetrazole compounds and their application researches as medicinal drugs, agrochemicals and materials.

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“…should have the highest anti-fibrinolytic efficacy. Considering oxidative stress is one of the risk factors in the development of cardiovascular diseases and indole is a free radical scavenger and able to alleviate the adverse effects of stress factors, has broad-spectrum antioxidant activity and is a potent stimulator of immune function, [21][22][23] the aminoacyl at the 2-position was focused on tryptophanyl. Herein we used a model system to evaluate the anti-fibrinolytic efficacy and to explore the action mechanism of CIPPC as a novel u-PA (urokinase-PA, UK-PA) inhibitor.…”

Section: Papermentioning

confidence: 99%

From Cerius2 based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors

et al. 2011

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Antifibrinolytic therapy during major complex surgery could reduce blood loss and allogeneic transfusion. Novel antagonists of the plasminogen activator and the corresponding model system are of clinical importance. In this paper (1S,2'S,3S)-1-[2-(S)-carboxylindolemethylenemethineaminoeth-1-yl]-2,3,4,5-tetrahydropyrolo[1,2:1,6]pyrazino[3,4:2,3]-1,2,3,4-tetrahydrocarboline-2,5-dione (CIPPC) was presented as a novel antagonist of plasminogen activator, and its blood coagulation and action mechanism were investigated by using a model system which consisted of a mouse-tail bleeding assay, in vitro and in vivo fibrinolysis inhibition assays, a thrombus formation assay and a plasminogen (PLG) electrophoresis assay.

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Development of new indole-derived neuroprotective agents

Cited by 22 publications

References 38 publications

Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Recent Advances in the Synthesis and Application of Tetrazoles

From Cerius2 based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors

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