Development of new leukoplakias and leukoplakia-associated second/multiple primary oral cancers: A case report and literature review

Potentially malignant disorders—The case for intervention

“…Following successful primary therapy, local PMD recurrence and development of new‐site lesions may occur, but careful patient follow‐up facilitates early identification and further laser treatment can be administered. Whilst most patients in our study series required only one laser treatment, a mean number of 2.26 treatments over a mean time of 32.9 months ultimately rendered over 74% of 590 PMD patients disease free despite initial presentation with significant dysplasia …”

“…1,2 Review of CO 2 laser treatment studies shows that 51%-89% of PMD patients are rendered free of disease, with only 10%-34% exhibiting further disease 8,[35][36][37][38][39][40] ; this contrasts with observational treatment in which 77% of lesions persist. 41 Following successful primary therapy, local PMD recurrence and development of new-site lesions may occur, 42 transformation rates for patients whose lesions were not excised, compared with around 5-6% where lesions were removed. 3,43 Excluding SCCs excised "unexpectedly," we have noted between 2% and 5% of PMD patients developing same or new-site cancer formation during post-treatment follow-up.…”