2024
DOI: 10.1002/cmdc.202400330
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Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties

Elisabetta Scalia,
Antony Chirco,
Lorenzo Calugi
et al.

Abstract: The ability of synthetic peptides inhibitors of NOX1 to effectively block the production of ROS by the enzyme was studied with different methodologies. Specifically, taking advantage of our understanding of the active epitope of the regulatory NOX1 subunit NOXA1 as a potent inhibitor of NOX1‐derived O2•‐ formation, a panel of peptidomimetic derivatives of this peptide were designed and synthesized with the aim of improving their activity and increasing their stability in plasma. The results highlighted that im… Show more

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