Development of New Serum Biomarkers for Early Lymphedema Detection

Herrada, Andrés A.; Mejías, Camila; Lazo-Amador, Rodrigo; Olate‐Briones, Alexandra; Lara, Danitza; Escobedo, Noelia

doi:10.1089/lrb.2019.0008

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…68,69 Visser et al 70 recently identified 18 genes influencing BCRL risk, adding to the mechanistic theory of BCRL development. Evolving data also suggest that inflammatory, 71 immunologic, 72,73 and extracellular matrix modulator 73 biomarkers may influence BCRL risk. In fact, pilot studies demonstrate promise for oral antiinflammatory medications such as ketoprofen in lymphedema treatment.…”

Section: The Future Of Bcrlmentioning

confidence: 99%

Breast Cancer–Related Lymphedema: Risk Factors, Screening, Management, and the Impact of Locoregional Treatment

McLaughlin

Brunelle

Taghian

2020

JCO

109

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Section: The Future Of Bcrlmentioning

confidence: 99%

Breast Cancer–Related Lymphedema: Risk Factors, Screening, Management, and the Impact of Locoregional Treatment

McLaughlin

Brunelle

Taghian

2020

JCO

109

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“…Moreover, an increased number of macrophages in the lymphedematous limb have been observed ( 73 , 74 ). We have now shown in a mouse model of tail lymphedema increased numbers of M2 macrophages in the lymphedematous tissue at early days after lymphatic ablation, when lymph accumulation reaches a peak ( 33 ), suggesting that lymph could promote an anti-inflammatory macrophages polarization in vivo . These results are in line with a previous paper that showed increased number of M2 macrophages at later time points after ablation of lymphatic vessels ( 23 ).…”

Section: Discussionmentioning

confidence: 94%

“…Acquired lymphedema was surgically induced in the tails of C57BL/6 mice as previously described ( 33 , 34 ). Briefly, a full-thickness circumferential incision of the skin was made 15 mm distal to the base of the mouse tail.…”

Section: Methodsmentioning

confidence: 99%

Lymph Leakage Promotes Immunosuppression by Enhancing Anti-Inflammatory Macrophage Polarization

et al. 2022

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Lymphatic vasculature is a network of capillaries and vessels capable of draining extracellular fluid back to blood circulation and to facilitate immune cell migration. Although the role of the lymphatic vasculature as coordinator of fluid homeostasis has been extensively studied, the consequences of abnormal lymphatic vasculature function and impaired lymph drainage have been mostly unexplored. Here, by using the Prox1+/– mice with defective lymphatic vasculature and lymphatic leakage, we provide evidence showing that lymph leakage induces an immunosuppressive environment by promoting anti-inflammatory M2 macrophage polarization in different inflammatory conditions. In fact, by using a mouse model of tail lymphedema where lymphatic vessels are thermal ablated leading to lymph accumulation, an increasing number of anti-inflammatory M2 macrophages are found in the lymphedematous tissue. Moreover, RNA-seq analysis from different human tumors shows that reduced lymphatic signature, a hallmark of lymphatic dysfunction, is associated with increased M2 and reduced M1 macrophage signatures, impacting the survival of the patients. In summary, we show that lymphatic vascular leakage promotes an immunosuppressive environment by enhancing anti-inflammatory macrophage differentiation, with relevance in clinical conditions such as inflammatory bowel diseases or cancer.

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“…Several kinds of research showed that LTB4 might consider as a diagnostic biomarker for inflammation cases of lymphedema, preeclampsia, obstructive pulmonary disease, and diabetic neuropathy [11][12][13][14]. However, regarding the authors' knowledge, LTB4 studies as a risk factor for PDN have never been done in Indonesia before.…”

Section: Open Accessmentioning

confidence: 99%

High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients

Yuwanda

Widyadharma

Samatra

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient. Results Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4, p 0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37; p = 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25; p = 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470; p = 0.017). Conclusions In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment.

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Development of New Serum Biomarkers for Early Lymphedema Detection

Cited by 8 publications

References 45 publications

Breast Cancer–Related Lymphedema: Risk Factors, Screening, Management, and the Impact of Locoregional Treatment

Breast Cancer–Related Lymphedema: Risk Factors, Screening, Management, and the Impact of Locoregional Treatment

Lymph Leakage Promotes Immunosuppression by Enhancing Anti-Inflammatory Macrophage Polarization

High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients

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