Development of Noninvasive Velocity Flow Video Urodynamics Using Doppler Sonography. Part Ii: Clinical Application in Bladder Outlet Obstruction

Ozawa, Hideo; Kumon, Hiromi; Yokoyama, Teruhiko; Watanabe, Tetsu; Chancellor, Michael B.

doi:10.1016/s0022-5347(01)62412-1

Cited by 32 publications

(28 citation statements)

References 14 publications

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“…A robust, ingrown, and therefore pinned biofilm forms on the control PTFE substrate, whereas biofilm on the SLIPS substrate slides readily without leaving any slime film or other visible residue (see Movie S2). aggressive, on the order of 10-100 cm∕s, although 1-10 cm∕s is more typical (52,53). In addition to flow, we further examined the robustness of slippery behavior of SLIPS against extreme environmental conditions: 7 d immersion in concentrated brine (10 times the salinity of ocean water), in acid (pH approximately 1) and base (pH approximately 14), as well as exposure to 1000 kJ∕m 2 of UV, which is approximately the annual UV exposure in the southwestern United States.…”

Section: Resultsmentioning

confidence: 99%

Liquid-infused structured surfaces with exceptional anti-biofouling performance

Epstein

Wong

Belisle³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

833

750

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Bacteria primarily exist in robust, surface-associated communities known as biofilms, ubiquitous in both natural and anthropogenic environments. Mature biofilms resist a wide range of antimicrobial treatments and pose persistent pathogenic threats. Treatment of adherent biofilm is difficult, costly, and, in medical systems such as catheters or implants, frequently impossible. At the same time, strategies for biofilm prevention based on surface chemistry treatments or surface microstructure have been found to only transiently affect initial attachment. Here we report that Slippery LiquidInfused Porous Surfaces (SLIPS) prevent 99.6% of Pseudomonas aeruginosa biofilm attachment over a 7-d period, as well as Staphylococcus aureus (97.2%) and Escherichia coli (96%), under both static and physiologically realistic flow conditions. In contrast, both polytetrafluoroethylene and a range of nanostructured superhydrophobic surfaces accumulate biofilm within hours. SLIPS show approximately 35 times the reduction of attached biofilm versus best case scenario, state-of-the-art PEGylated surface, and over a far longer timeframe. We screen for and exclude as a factor cytotoxicity of the SLIPS liquid, a fluorinated oil immobilized on a structured substrate. The inability of biofilm to firmly attach to the surface and its effective removal under mild flow conditions (about 1 cm∕s) are a result of the unique, nonadhesive, "slippery" character of the smooth liquid interface, which does not degrade over the experimental timeframe. We show that SLIPS-based antibiofilm surfaces are stable in submerged, extreme pH, salinity, and UV environments. They are low-cost, passive, simple to manufacture, and can be formed on arbitrary surfaces. We anticipate that our findings will enable a broad range of antibiofilm solutions in the clinical, industrial, and consumer spaces.antifouling surfaces | biofilm resistance | slippery materials | surface engineering

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Section: Resultsmentioning

confidence: 99%

Liquid-infused structured surfaces with exceptional anti-biofouling performance

Epstein

Wong

Belisle³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

833

750

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“…We have developed a method of totally noninvasive color Doppler urodynamic evaluation in combination with standard uroflowmetry [11,12] and also demonstrated the intra-and inter-rater reliability of this system [18]. Flow velocity in the distal prostatic urethra (V 1 ) and in the sphincteric urethra (V 2 ) were measured and a variety of velocity-flow-related parameters were developed [13].…”

Section: Discussionmentioning

confidence: 99%

“…Flow velocity in the distal prostatic urethra (V 1 ) and in the sphincteric urethra (V 2 ) were measured and a variety of velocity-flow-related parameters were developed [13]. Since VR and A 1 had a good correlation with the pressure-flow parameters (URA and Abrams-Griffith, AG, number) obtained from independent conventional pressure-flow studies, noninvasive pressure-flow-like urodynamic evaluation based on Doppler ultrasound proved to have a clear potential for diagnosing BOO [12]. So far, pressure flow study has been the gold standard for the diagnosis of BOO.…”

Section: Discussionmentioning

confidence: 99%

“…Our group has developed a totally noninvasive pressure-flow urodynamic system based on the concept of transperineal Doppler ultrasonography [11,12], and has proven that flow velocity can be noninvasively measured at any point along the urethra, and the functional crosssectional area of the prostatic urethra was significantly smaller in the obstructed group than in the unobstructed group [13]. The aim of this study was to verify the change in velocity-flow parameters before and after · 1 -blocker treatment for LUTS.…”

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confidence: 99%

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Change in Parameters before and after Alpha-1-Blocker Therapy for Men with Lower Urinary Tract Symptoms Using Color Doppler Ultrasound Urodynamics: Possible Application for Prediction of Clinical Outcome

Watanabe¹,

Yokoyama²,

Ozawa³

et al. 2004

Urol Int

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Introduction: We previously developed a noninvasive video urodynamic study using color Doppler ultrasonography. We sought the best flow velocity-related parameter which would allow prediction of an improvement in lower urinary tract symptoms (LUTS) after α₁-blocker treatment. Methods: Twenty-two men with benign prostatic hyperplasia who were treated with a nonselective α₁-blocker (urapidil) were included. Subjective symptoms were evaluated using the International Prostate Symptom Score (IPSS) before and after α₁-blocker treatment. We measured the flow velocities using a transperineal ultrasound technique in the distal prostatic urethra just proximal to the external urethral sphincter (V₁) and in the sphincteric urethra (V₂), and used them to obtain the velocity ratio (VR = V₁/V₂). The corresponding functional cross-sectional areas of the urethra at these two sites (A₁ and A₂) were calculated as Q_max/V. All these parameters obtained by the velocity-flow urodynamics were compared before treatment and after 4 weeks. Results: After treatment, V₁ and VR were decreased, and A₁ was increased. V₂ correlated best with the change in IPSS before and after α₁-blocker therapy, with Spearman’s rho of 0.584. All men with V₂ exceeding 50 cm/s did not show an improvement in the LUTS. Conclusions: The maximum flow velocity at the sphincteric urethra (V₂) can predict the subjective outcome of α₁-blocker treatment. The velocity-flow parameters changed after α₁-blocker treatment. We confirmed that the transperineal ultrasound urodynamic study is not only noninvasive but also informative.

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“…Rikken et al [44] described a noninvasive technique of pressure-flow study using an external condom catheter; by combining an isovolumetric bladder pressure measurement with an independently measured maximum flow rate, the authors hope to achieve a reliable noninvasive method of diagnosing BOO in males. Ozawa et al [45] developed a totally noninvasive method of measuring urethral flow velocity by Doppler sonography and uroflowmetry. By dividing the flow rate by flow velocity, the functional cross-sectional area of the prostatic urethra is estimated.…”

Section: Pitfalls Of Pressure-flow Studiesmentioning

confidence: 99%

Current concepts and controversies in urodynamics

Kelly

Krane

2000

Curr Urol Rep

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Urodynamics is the dynamic study of the transport, storage, and evacuation of urine by the urinary tract. It is comprised of several tests that, when used individually or collectively, can give information about lower urinary tract function. The components of the urodynamic study are uroflowmetry, cystometry, pressure-flow studies, electromyography, urethral pressure profilometry, leak point pressure measurement, videourodynamics, and ambulatory urodynamics. Familiarity with the recent advances and controversies of each component is essential when using urodynamics to diagnose and treat lower urinary tract dysfunction.

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Development of Noninvasive Velocity Flow Video Urodynamics Using Doppler Sonography. Part Ii: Clinical Application in Bladder Outlet Obstruction

Abstract: The concept of noninvasive pressure flow-like urodynamic evaluation based on Doppler ultrasound is feasible. Parameters of flow velocity as well as functional cross-sectional area can be used in the diagnosis of bladder outlet obstruction and to localize the site of obstruction.

Cited by 32 publications

References 14 publications

Liquid-infused structured surfaces with exceptional anti-biofouling performance

Liquid-infused structured surfaces with exceptional anti-biofouling performance

Change in Parameters before and after Alpha-1-Blocker Therapy for Men with Lower Urinary Tract Symptoms Using Color Doppler Ultrasound Urodynamics: Possible Application for Prediction of Clinical Outcome

Current concepts and controversies in urodynamics

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