Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system

Kan, Pei; Chen, Zhi-Beng; Lee, Chau-Jen; Chu, I‐Ming

doi:10.1016/s0168-3659(98)00164-3

Cited by 111 publications

(63 citation statements)

References 15 publications

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“…The phase behavior of this block copolymer is strongly affected by liposomes even when thermoreversibility (16,18,21,24, and 27 wt%) and B) 18% F127 gel containing pure liposome (low, medium, and high lipid content) solution, pure 18% F127 gel, and pure liposome (with high lipid content) by differential scanning calorimetry analysis at a scanning rate of 5°C/min. For better illustration of the sol-gel transition, the derivative heat flow was plotted against temperature.…”

Section: Thermal Analysis Of Thermo-sensitive F127 Systemmentioning

confidence: 99%

“…New formulations that overcome these problems will have clear clinical advantages. In recent years, various groups of researchers have investigated the development of novel formulations for PTX, including liposomes, [10][11][12][13][14][15] emulsions, [16][17][18][19] cyclodextrins, [20][21][22] microspheres, 23,24 nanoparticles, [25][26][27][28][29][30][31] and implants. [32][33][34][35] In addition, injectable thermoreversible hydrogels are also being developed with reasonable success for PTX delivery.…”

Section: Introductionmentioning

confidence: 99%

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Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nie¹,

Hsiao²,

Pan³

et al. 2011

IJN

119

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Purpose To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic ® F127 gel) for controlled release and improved antitumor drug efficiency. Methods The dialysis membrane and membrane-less diffusion method were used to investigate the in vitro drug release behavior. Differential scanning calorimetry (DSC) thermal analysis was used to investigate the “micellization” and “sol/gel transition” process of in situ gel systems. In vitro cytotoxicity and drug uptake in KB cancer cells were determined by MTT, intercellular drug concentration, and fluorescence intensity assay. Results The in vitro release experiment performed with a dialysis membrane model showed that the liposomal gel exhibited the longest drug-release period compared with liposome, general gel, and commercial formulation Taxol ® . This effect is presumably due to the increased viscosity of liposomal gel, which has the effect of creating a drug reservoir. Both drug and gel release from the in situ gel system operated under zero-order kinetics and showed a correlation of release of PTX with gel, indicating a predominating release mechanism of the erosion type. Dispersing liposomes into the gel replaced larger gel itself for achieving the same gel dissolution rate. Both the critical micelle temperature and the sol/gel temperature, detected by DSC thermal analysis, were shifted to lower temperatures by adding liposomes. The extent of the shifts depended on the amount of embedded liposomes. MTT assay and drug uptake studies showed that the treatment with PTX-loaded liposomal 18% Pluronic F127 yielded cytotoxicities, intercellular fluorescence intensity, and drug concentration in KB cells much higher than that of conventional liposome, while blank liposomal 18% Pluronic F127 gel was far less than the Cremophor EL ® vehicle and empty liposomes. Conclusions A thermosensitive hydrogel with embedded liposome is a promising carrier for hydrophobic anticancer agents, to be used in parenteral formulations for treating local cancers.

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Section: Thermal Analysis Of Thermo-sensitive F127 Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nie¹,

Hsiao²,

Pan³

et al. 2011

IJN

119

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“…Monoolein was included in the formulation as a main ingredient due to its high bioadhesiveness (Nielsen et al, 1998) and its ability to release the encapsulated drug in a controlled fashion (Clogston et al, 2005a(Clogston et al, , 2005b. Triglycerides were added since they can solubilize paclitaxel efficiently (Kan et al, 1999). To access the effectiveness of the formulations, pharmacokinetic and antitumor efficacy studies were performed in mice models.…”

Section: Introductionmentioning

confidence: 99%

Development, Optimization and Absorption Mechanism of DHP107, Oral Paclitaxel Formulation for Single-Agent Anticancer Therapy

Lee¹,

Hong²,

Jang³

et al. 2012

New Advances in the Basic and Clinical Gastroenterology

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“…Other poorly water-soluble drugs have been formulated in o/w emulsions and are currently being extensively studied, including such drugs as paclitaxel [8][9][10] and cyclosporin A [11]. Emulsions with phosphatidylcholine as the major emulsifier have also been widely used as a source of energy in parenteral nutrition (fat emulsions).…”

Section: Introductionmentioning

confidence: 99%

Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect

Jaromin

Żarnowski

Kozubek

2006

Cellular and Molecular Biology Letters

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Abstract:In our previous study, we developed very stable formulations of submicron oil-in-water emulsions from Adenanthera pavonina L. (family Leguminosae, subfamily Mimosoideae) seed oil, stabilised with soybean lecithin (SPC). Continuing our research, we introduced an additional co-emulsifier, Tween 80, to those formulations in order to decrease the size of the emulsion particles and improve their stability. Formulations with a mean particle size ranging from 43.6 to 306.5 nm and a negative surface charge from -45.3 to -28.5 mV were obtained. Our stability experiments also revealed that most of the tested formulations had a very good degree of stability over a 3-month storage period, both at 4ºC and at room temperature. Since many intravenous injectable drugs exhibit lytic activity against erythrocytes, we examined this activity for the emulsion form of cardol, a natural compound with already proven hemolytic properties. The incorporation of this agent into the emulsion caused an evident decrease in hemolytic activity (97-99%). This highly protective effect, observed against sheep erythrocytes, was independent of both the composition and the particle size of the emulsions used. Our studies suggest that nonionic surfactant/phospholipid-based emulsions containing this edible oil of A. pavonina L. may be useful as an alternative formulation matrix for pharmaceutical, nutritional or cosmetic applications of otherwise membrane-acting components.

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Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system

Cited by 111 publications

References 15 publications

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Development, Optimization and Absorption Mechanism of DHP107, Oral Paclitaxel Formulation for Single-Agent Anticancer Therapy

Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect

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Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system

Cited by 111 publications

References 15 publications

Thermoreversible Pluronic&reg; F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic&reg; F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Development, Optimization and Absorption Mechanism of DHP107, Oral Paclitaxel Formulation for Single-Agent Anticancer Therapy

Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect

Contact Info

Product

Resources

About

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies