Development of novel biocompatible hybrid nanocomposites based on polyurethane-silica prepared by sol gel process

Rashti, Ali; Yahyaei, Hossein; Firoozi, Saman; Ramezani, Sara; Rahiminejad, Ali; Karimi, Roya; Farzaneh, Khadijeh; Mohseni, Mohsen; Ghanbari, Hossein

doi:10.1016/j.msec.2016.08.037

Cited by 37 publications

(27 citation statements)

References 28 publications

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“…From the 1980s until nowadays, a huge development in the sol-gel process was achieved. The research conducted allowed them to obtain OIH materials with applications in a wide range of areas, such as chemical and biosensors [13,85,86], in several transduction modes, from electrochemical [87][88][89][90][91] to optical [13,[92][93][94][95]; biomaterials for drug delivery [24,[96][97][98][99][100]; materials for improving bioactivity and biocompatibility of metallic substrates [101][102][103][104][105][106][107][108]; electronics [14]; environment [109][110][111]; optics [13,112,113]; medicine [53,[114][115][116][117]; functional smart coatings [31,38,73,118]; fuel and solar cells [119][120][121]…”

Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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The corrosion process is a major source of metallic material degradation, particularly in aggressive environments, such as marine ones. Corrosion progression affects the service life of a given metallic structure, which may end in structural failure, leakage, product loss and environmental pollution linked to large financial costs. According to NACE, the annual cost of corrosion worldwide was estimated, in 2016, to be around 3%-4% of the world's gross domestic product. Therefore, the use of methodologies for corrosion mitigation are extremely important. The approaches used can be passive or active. A passive approach is preventive and may be achieved by emplacing a barrier layer, such as a coating that hinders the contact of the metallic substrate with the aggressive environment. An active approach is generally employed when the corrosion is set in. That seeks to reduce the corrosion rate when the protective barrier is already damaged and the aggressive species (i.e., corrosive agents) are in contact with the metallic substrate. In this case, this is more a remediation methodology than a preventive action, such as the use of coatings. The sol-gel synthesis process, over the past few decades, gained remarkable importance in diverse areas of application. Sol-gel allows the combination of inorganic and organic materials in a single-phase and has led to the development of organic-inorganic hybrid (OIH) coatings for several applications, including for corrosion mitigation. This manuscript succinctly reviews the fundamentals of sol-gel concepts and the parameters that influence the processing techniques. The state-of-the-art of the OIH sol-gel coatings reported in the last few years for corrosion protection, are also assessed. Lastly, a brief perspective on the limitations, standing challenges and future perspectives of the field are critically discussed.Polymers 2020, 12, 689 The development of OIH sol-gel coatings, based on siloxanes, for corrosion mitigation, has been widely studied in the last few years [2,31,[36][37][38]. Numerous studies have been conducted since the early 1990s [39,40]. The studies performed showed that siloxanes were effective in mitigating the corrosion processes of different metallic substrates. This development was mainly due to the need for alternative environmentally friend materials and processes to replace the traditional chromium-based pre-treatments. Hexavalent chromium (Cr (VI)) is carcinogenic and shows high environmental toxicity and its use has been forbidden since 2006. However, Cr(VI) based pre-treatments improve the coating adherence to the substrate and are effective corrosion inhibitors [41][42][43] which make its replacement challenging. The use of the sol-gel method to produce OIH coatings for corrosion mitigation suits the main requirements of what should be an environmentally friendly process (i.e., excludes washing stages; it is a waste-free method) and allows one to obtain coatings with high purity and specific pore volumes and surface areas. Since it is a mild synthesis...

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Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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“…Silica is bioinert, easily functionalizable, and can be readily encapsulated in the polymeric coatings commonly used in the design and fabrication of a given device. [18][19][20] Preliminary studies using SNP-based NO-releasing intravascular catheter coatings and subcutaneous glucose sensor membranes have shown reduced thrombosis and tissue inflammation, respectively. 21,22 The promising results from these studies prompted the development of more efficient and effective NO-delivery systems to achieve targeted, tunable, and extended delivery of NO from polymeric coatings.…”

Section: Introductionmentioning

confidence: 99%

Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles

Malone-Povolny

Schoenfisch

2019

ACS Appl. Mater. Interfaces

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S-nitrosothiol (RSNO)-modified mesoporous silica nanoparticles (MSNs) were doped into polyurethane (PU) to achieve extended NO-releasing coatings. Parameters influencing the synthesis of RSNO-functionalized nitric oxide (NO)-releasing MSNs were evaluated to elucidate the impact of pore structure on NO-release characteristics. The porous particles were characterized as having larger NO payloads and longer NO-release durations than that of nonporous particles, a feature attributed to recombination of the NO radical in confined intraporous microenvironments. Nitric oxide-release kinetics, particle leaching, and thermal stability of the RSNO-modified MSNs dispersed in PU were evaluated as a function of PU structure to determine the feasibility of preparing a range of NO-releasing polymers for biomedical device coating applications. The NOrelease kinetics from the PUs proved to be highly extended (>30 d) and consistent over a range of polyurethane properties. Furthermore, RSNO-modified MSN leaching was not observed from the PUs. The NO-release payloads were also maintained for 4 days for polymers stored at 0 °C.

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“…The biocompatibility of nanomaterials plays a crucial role in their potential biomedical applications [ 26 , 27 ]. In this study, the in vitro cytotoxicity effect of the prepared PNS-SS-ADA@CD-mPEG, free DOX,and DOX/PNS-SS-ADA@CD-mPEG against HeLa cells was determined.…”

Section: Resultsmentioning

confidence: 99%

Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

Nguyen

Bao

et al. 2018

International Journal of Biomaterials

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Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG. The prepared PNS-SS-ADA@CD-mPEG nanoparticles were spherical in shape with an average diameter of 55.5 ± 3.05 nm, a little larger than their parentally PNS nanocarriers, at 49.6 ± 2.56 nm. In addition, these nanoparticles possessed high drug loading capacity, at 79.2 ± 3.2%, for controlled release. The release of DOX from DOX/PNS-SS-ADA@CD-mPEG nanoparticles was controlled and prolonged up to 120 h in PBS medium (pH 7.4), compared to less than 40 h under reducing condition of 5 mM DTT. Notably, the PNS-SS-ADA@CD-mPEG was a biocompatible nanocarrier, and the toxicity of DOX was dramatically reduced after loading drugs into the porous core. This redox-sensitive PNS-SS-ADA@CD-mPEG nanoparticle could be considered a potential candidate with high drug loading capacity and a lower risk of systemic toxicity.

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Development of novel biocompatible hybrid nanocomposites based on polyurethane-silica prepared by sol gel process

Cited by 37 publications

References 28 publications

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles

Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

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