2018
DOI: 10.1080/21691401.2018.1430584
|View full text |Cite
|
Sign up to set email alerts
|

Development of novel biofunctionalized chitosan decorated nanocochleates as a cancer targeted drug delivery platform

Abstract: A new family of biofunctionalized chitosan decorated nanocochleates-mediated drug delivery system was developed that involves uniquely combining nanocochleates with anticancer drug for controlled drug release, targeted delivery, improved bioavailability with reduced toxicity. This system was developed by loading of doxorubicin (DOX) to nanocochleates (DOX-NC) through conversion of negatively charged dimyristoylphosphatidylcholine (DMPC) phospholipid and cholesterol-bearing vesicles on addition of calcium ions,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 21 publications
(8 citation statements)
references
References 38 publications
0
8
0
Order By: Relevance
“…CS is soluble in acidic pH due to the protonation of primary amino groups on CS under acidic conditions. So, niosomal formulations are pH-sensitive because the drugs are selectively released in the targeted site. , …”
Section: Introductionmentioning
confidence: 99%
“…CS is soluble in acidic pH due to the protonation of primary amino groups on CS under acidic conditions. So, niosomal formulations are pH-sensitive because the drugs are selectively released in the targeted site. , …”
Section: Introductionmentioning
confidence: 99%
“…These lipid-based carriers are stable precipitates of phospholipid cation consisting of naturally occurring materials phosphatidylserine and calcium ion in general. In the formulation of nanocochleate continuous lipid bilayers sheet rolled up in a way that developed spiral structure without inner aqueous phase between them cochleares differing from liposomes in having cylindrical shaped and water-free interior structure [9][10][11].…”
Section: Basics Of Nanocochleatesmentioning
confidence: 99%
“…In the case of other routes except intravenous, they cross and enter into circulation through the epithelium cell. They are supplied to the targeted cell after they reach into circulation [10].…”
Section: Absorption From Intestinementioning
confidence: 99%
See 2 more Smart Citations