Development of novel cationic microemulsion as parenteral adjuvant for influenza vaccine

Lamaisakul, Sakalanunt; Tantituvanont, Angkana; Lipipun, Vimolmas; Ritthidej, Garnpimol C.

doi:10.1016/j.ajps.2019.08.002

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…The osmolarity requirements for injection preparations fall in the range of 200-300 m Osmol. A high osmolarity level can potentially lead to pain and burning sensations during injection [16] and the specific value depends on the number of moles in the chemical compound. Based on the results, MK fell in the acceptable range for injection preparation requirements.…”

Section: Osmolarity Ph and Viscositymentioning

confidence: 99%

“…It is an excellent carrier for hydrophilic and hydrophobic drugs in parenteral formulations due to the superior stability compared to nanoemulsions and those with a size below 50 nm [11,15]. This compound can be used as carrier for parenteral vaccines to enhance the cellular immune response to viruses [16]. Compared to other colloidal carriers, microemulsion can effectively serve as drug delivery system for hydrophobic drugs due to the unique characteristics, including thermodynamic stability, tiny droplet size, and ease of fabrication attributed to the role of the oil component [17].…”

Section: Introductionmentioning

confidence: 99%

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Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

UL HAFIZAH,

SUGITA,

KHOTIB

et al. 2024

Int J App Pharm

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Objective: This study aimed to develop, characterize, and conduct stability evaluations to ensure compliance with intravenous administration for microemulsion ibuprofen injection. In addition, hematology assessment and profile of drug release kinetics were analyzed. Methods: The formulation process commenced by introducing various chitosan concentrations into microemulsion ibuprofen injection, following a method established in a previous study. Formulation parameters studied include particle size, polydispersity index (PDI), zeta potential, kinetic of drug release, anti-inflammation activity using the 1% carrageenin induction method, and hematology assessment. Results: The results showed that the addition of 1% chitosan solution allowed for the development of the ideal microemulsion formula, with droplet size, zeta potential, and PDI of 19.37±0.32 nm,-1.53±0.12 mV, and 0.38±0.02, respectively. Kinetics of chitosan-coated ibuprofen microemulsion (MK) were governed by the squared root of time paradigm, suggesting that drug release proceeded by diffusion and was influenced by the carrier. Compared to the other groups, the paw injected with MK indicated a strong anti-inflammatory effect and did not differ significantly from the control group (p>0.05). However, Hematology analysis showed no statistically significant variations in leukocyte and erythrocyte profiles between the treatment and control groups (p>0.05). Conclusion: MK met the criteria as an intravenous preparation based on the characteristics and safety.

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Section: Osmolarity Ph and Viscositymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

UL HAFIZAH,

SUGITA,

KHOTIB

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Si bien, generalmente, se prefiere el uso de emulsionantes no iónicos, también es posible realizar emulsiones nanométricas con emulsionantes iónicos con bajos efectos celulares [79]. Existen diversos métodos para comprobar la seguridad de estos preparados y que se corresponden con su potencial uso.…”

Section: Farmacéutica Y Biomedicinaunclassified

Una visión actualizada sobre la síntesis, escalado y aplicaciones de las nanoemulsiones dobles

Jerez

Oyarzún

2021

Entre cienc. ing.

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Las nanoemulsiones son sistemas emulsionados de tamaño nanométrico. Estas pueden ser producidas mediante diversos métodos, los cuales se pueden clasificar como métodos de baja y alta energía. La disminución en el tamaño de glóbulo formado permite que estas puedan penetrar con mayor facilidad diferentes barreras como la piel o la barrera gastrointestinal. De este modo la encapsulación de compuestos activos a través de nanoemulsiones permite mejorar su biodisponibilidad. Además de ofrecer protección frente a factores ambientales como temperatura, humedad o radiación UV. Asimismo, es posible formular nanoemulsiones dobles con el fin de encapsular moléculas de naturaleza hidrofílica y lipofílica en un solo glóbulo. Este proceso de formación requiere un análisis integral que incluye aproximaciones físicas y termodinámicas.

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“…They offer several advantages, including improved drug solubility, increased bioavailability of poorly water-soluble drugs, and enhanced chemical stability [ 16 , 21 , 22 , 23 ]. The intensive utilization of MEs spans various administration routes, including oral [ 24 , 25 , 26 , 27 ], topical [ 28 , 29 , 30 , 31 ], and parenteral [ 32 , 33 , 34 , 35 ], establishing them as promising carrier systems for delivering a broad spectrum of active ingredients, including drugs that are either water-soluble or poorly water-soluble [ 11 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

Leanpolchareanchai

Teeranachaideekul

2023

Pharmaceuticals

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Microemulsions (MEs) have gained prominence as effective drug delivery systems owing to their optical transparency, low viscosity, and thermodynamic stability. MEs, when stabilized with surfactants and/or co-surfactants, exhibit enhanced drug solubilization, prolonged shelf life, and simple preparation methods. This review examines the various types of MEs, explores different preparation techniques, and investigates characterization approaches. Plant extracts and bioactive compounds are well established for their utilization as active ingredients in the pharmaceutical and cosmetic industries. Being derived from natural sources, they serve as preferable alternatives to synthetic chemicals. Furthermore, they have demonstrated a wide range of therapeutic effects, including anti-inflammatory, antimicrobial, and antioxidant activities. However, the topical application of plant extracts and bioactive compounds has certain limitations, such as low skin absorption and stability. To overcome these challenges, the utilization of MEs enables enhanced skin absorption, thereby making them a valuable mode of administration. However, considering the significant surfactant content in MEs, this review evaluates the potential skin irritation caused by MEs containing herbal substances. Additionally, the review explores the topical application of MEs specifically for herbal substances, with an emphasis on their anti-inflammatory properties.

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Development of novel cationic microemulsion as parenteral adjuvant for influenza vaccine

Cited by 7 publications

References 32 publications

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

Una visión actualizada sobre la síntesis, escalado y aplicaciones de las nanoemulsiones dobles

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

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