Development of novel gastroretentive salbutamol sulfate-loaded sodium alginate-pectin bubble beads prepared by co-axial needle air-injection method and in vivo clinical evaluation by ultrasound studies

Devi, Pooja; Rathor, Sandeep; Sharma, Pratibha; Sen, Jyotsna; Kaur, Harmeet; Singh, Jasbir

doi:10.1016/j.ejps.2018.07.019

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…The explants undergo immersion in a sodium alginate solution and are subsequently placed in a calcium chloride solution to facilitate the formation of the alginate capsule. The balance between these two solutions is fundamental, and the ion exchange between them varies depending on the explant and the species to be encapsulated [32]. At concentrations of less than 3% for sodium alginate and less than of 100 mM for CaCl 2 , the alginate beads in Teucrium polium L. were very loose and unable to cover the plant tissue, while concentrations higher than 3% resulted in the darkening of plant tissues and the absence of germinated plants [33].…”

Section: Discussionmentioning

confidence: 99%

Synthetic Seed Production and Slow Growth Storage of In Vitro Cultured Plants of Iris pallida Lam.

Meucci,

Ghelardi,

Chietera

et al. 2024

Horticulturae

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Iris pallida Lam. is traditionally cultivated in Italy to sell its rhizomes to perfume-producing industries and is particularly sought-after because of its high content of irones, ketone compounds responsible for the violet smell of the orris essence. One of the critical aspects of its cultivation is the propagation method, performed by subdividing and replanting sections of the rhizome, which leads to the sacrifice of salable material. A solution is provided via in vitro propagation using the somatic embryogenesis technique, an effective method that allows the production of plants without the use of the rhizome. To facilitate the scale up of the activities of micropropagation companies, the method of slow growth storage (SGS) for orris plantlets and a somatic embryo encapsulation technique were developed for the first time. Orris plantlets were placed at 4 °C in the dark for 30, 60, 90 and 120 days and monitored 7 and 30 days after treatment. Synthetic seeds were obtained by encapsulating somatic orris embryos in sodium alginate beads, which were stored for 14 and 28 days at 4 °C and 24 °C. The results showed that it is possible to cold-preserve orris plantlets for up to 90 days without significant damages and that orris synthetic seeds can be produced and stored for a short-to-mid-term period. These conservation techniques can be useful for germplasm conservation and can also be integrated in the micropropagation cycle of orris, helping to solve issues related to the traditional propagation method.

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Section: Discussionmentioning

confidence: 99%

Synthetic Seed Production and Slow Growth Storage of In Vitro Cultured Plants of Iris pallida Lam.

Meucci,

Ghelardi,

Chietera

et al. 2024

Horticulturae

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“…Sonographic images were captured at 0, 2, 4, 8 and 12 h. The participant had unrestricted access to water during the investigations. The radiologist eventually evaluated and verified the study results [ 56 ].…”

Section: Methodsmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability

et al. 2023

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The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating tablets of silymarin to improve its oral bioavailability and solubility. Hydroxypropyl methylcellulose (HPMCK4M and HPMCK15), Carbopol 934p and sodium bicarbonate were used as a matrix, floating enhancer and gas generating agent, respectively. The prepared tablets were evaluated for physicochemical parameters such as hardness, weight variation, friability, floating properties (floating lag time, total floating time), drug content, stability study, in vitro drug release, in vivo floating behavior and in vivo pharmacokinetics. The drug–polymer interaction was studied by Differential Scanning Calorimetry (DSC) thermal analysis and Fourier transform infrared (FTIR). The floating lag time of the formulation was within the prescribed limit (<2 min). The formulation showed good matrix integrity and retarded the release of drug for >12 h. The dissolution can be described by zero-order kinetics (r2 = 0.979), with anomalous diffusion as the release mechanism (n = 0.65). An in vivo pharmacokinetic study showed that Cmax and AUC were increased by up to two times in comparison with the conventional dosage form. An in vivo imaging study showed that the tablet was present in the stomach for 12 h. It can be concluded from this study that the combined matrix system containing hydrophobic and hydrophilic polymers min imized the burst release of the drug from the tablet and achieved a drug release by zero-order kinetics, which is practically difficult with only a hydrophilic matrix. An in vivo pharmacokinetic study elaborated that the bioavailability and solubility of silymarin were improved with an increased mean residence time.

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“…During the blending process, the vibrational mode of these polymers shifted slightly towards the lower wavenumber due to this intermolecular hydrogen bonding. Thermodynamically, this intermolecular interaction was favored due to the free energy of the molecules combined with the alginate-pectin as compared to its individual polymer [18]. The interaction between alginate and pectin causes a slight shifting of the aliphatic band from 2941 cm -1 in pectin to 2946 cm -1 .…”

Section: Synthesis Of Bromelain Loaded−alginate (Alg) Pectin (Pec) Alginate-pectin (Ap) Beadsmentioning

confidence: 99%

“…This stretching vibration is absent in individual polymers and proves that new COO groups form after the de-esterification process. There is a band at 1250-1050 cm -1 for the C-O-C stretch related to the glycoside bond of the biopolymer for the entire spectrum [18]. Uniformity, density, and sphericality of the bead size play crucial roles in drug release behavior in the GI tract.…”

Section: Synthesis Of Bromelain Loaded−alginate (Alg) Pectin (Pec) Alginate-pectin (Ap) Beadsmentioning

confidence: 99%

Encapsulation of Partially Purified Bromelain From Pineapple Cores in Alginate-Pectin Beads as a Targeted Antiplatelet Agent

2021

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Objective: Oral administration of bromelain can decrease its bioactivity once it makes contact with stomach acid. Therefore, bromelain was loaded into alginate (Alg), pectin (Pec), and alginate-pectin (AP) beads to control its release into the intestines and avoid degradation. Methods: Crude bromelain was purified by ammonium sulfate precipitation and the dialysis process. In vitro releases and kinetics studies of bromelain-loaded alginate-pectin beads were carried out using an acid and phosphate buffer medium. The beads were characterized using physical analysis, Fourier-Transform Infrared Spectroscopy (FTIR) analysis, and Differential Scanning Calorimetry (DSC) analysis. Results: The dialysis fraction of bromelain has a specific activity of 67.93 U/mg, 3.05 times that of crude bromelain. That fraction was encapsulated in Alg, Pec, and AP beads with a range of encapsulation efficiency around 82.70–91.39%. Bromelain-loaded pectin and AP19 beads were chosen to study in an in vitro release based on their swelling properties and encapsulation efficiency. Bromelain-loaded AP19 beads have lower release than bromelain-loaded pectin beads in both dissolution mediums. The cumulative releases of AP19 are 9.99 and 87.81% in 0.1 N HCl and phosphate buffer medium, respectively. Bromelain-loaded P and AP beads both follow the zero-order kinetics model and the dissolution mechanism of the beads is non-Fickian with a combination of diffusion and erosion. The in vitro antiplatelet activity of dissolution aliquots (20.51 and 18.48%) is lower than its dialysis fraction (56.04%). Conclusion: This in vitro research data shows promising potency for AP as a carrier for oral administration of bromelain as an antiplatelet agent.

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Development of novel gastroretentive salbutamol sulfate-loaded sodium alginate-pectin bubble beads prepared by co-axial needle air-injection method and in vivo clinical evaluation by ultrasound studies

Cited by 8 publications

References 45 publications

Synthetic Seed Production and Slow Growth Storage of In Vitro Cultured Plants of Iris pallida Lam.

Synthetic Seed Production and Slow Growth Storage of In Vitro Cultured Plants of Iris pallida Lam.

Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability

Encapsulation of Partially Purified Bromelain From Pineapple Cores in Alginate-Pectin Beads as a Targeted Antiplatelet Agent

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